6jxu - Revision history

OCA at 10:52, 14 June 2023

OCA — Wed, 14 Jun 2023 10:52:43 GMT

←Older revision		Revision as of 10:52, 14 June 2023
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	==SUMO1 bound to SLS4-SIM peptide from ICP0==		==SUMO1 bound to SLS4-SIM peptide from ICP0==
-	<StructureSection load='6jxu' size='340' side='right'caption='[[6jxu~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6jxu' size='340' side='right'caption='[[6jxu]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jxu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human ~~Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JXU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6JXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jxu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JXU FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUMO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jxu OCA], [https://pdbe.org/6jxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jxu RCSB], [https://www.ebi.ac.uk/pdbsum/6jxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jxu ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6jxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jxu OCA], [~~http~~://pdbe.org/6jxu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jxu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jxu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jxu ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN] Defects in SUMO1 are the cause of non-syndromic orofacial cleft type 10 (OFC10) [MIM:[https://omim.org/entry/613705 613705]; also called non-syndromic cleft lip with or without cleft palate 10. OFC10 is a birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note=A chromosomal aberation involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.<ref>PMID:16990542</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.<ref>PMID:9019411</ref> <ref>PMID:9162015</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]	+	[[Category: Homo sapiens]]
		+	[[Category: Human alphaherpesvirus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Das, R]]	+	[[Category: Das R]]
-	[[Category: Hembram~~, D S.S~~]]	+	[[Category: Hembram DSS]]
-	[[Category: Negi, H]]	+	[[Category: Negi H]]
-	[[Category: Shet, D]]	+	[[Category: Shet D]]
-	~~[[Category: Protein binding-peptide complex]]~~	+
-	~~[[Category: Sumoylation~~]]	+

OCA at 07:10, 27 May 2020

OCA — Wed, 27 May 2020 07:10:43 GMT

←Older revision		Revision as of 07:10, 27 May 2020
Line 3:		Line 3:
	<StructureSection load='6jxu' size='340' side='right'caption='[[6jxu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6jxu' size='340' side='right'caption='[[6jxu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jxu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JXU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6JXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jxu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JXU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JXU FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUMO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUMO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6jxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jxu OCA], [http://pdbe.org/6jxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jxu RCSB], [http://www.ebi.ac.uk/pdbsum/6jxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jxu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jxu OCA], [http://pdbe.org/6jxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jxu RCSB], [http://www.ebi.ac.uk/pdbsum/6jxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jxu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:32, 27 March 2020

OCA — Fri, 27 Mar 2020 10:32:21 GMT

←Older revision		Revision as of 10:32, 27 March 2020
Line 3:		Line 3:
	<StructureSection load='6jxu' size='340' side='right'caption='[[6jxu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6jxu' size='340' side='right'caption='[[6jxu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jxu]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jxu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JXU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jxu OCA], [http://pdbe.org/6jxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jxu RCSB], [http://www.ebi.ac.uk/pdbsum/6jxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jxu ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUMO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jxu OCA], [http://pdbe.org/6jxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jxu RCSB], [http://www.ebi.ac.uk/pdbsum/6jxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jxu ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	When the herpes simplex virus (HSV) genome enters the nucleus for replication and transcription, phase-segregated nuclear protein bodies called Promyelocytic leukemia protein nuclear bodies (PML NBs) colocalize with the genome and repress it. HSV encodes a small ubiquitin-like modifier (SUMO)-targeted ubiquitin ligase (STUbL) infected cell polypeptide 0 (ICP0) that degrades PML NBs to alleviate the repression. The molecular details of the mechanism used by ICP0 to target PML NBs are unclear. Here, we identify a bona fide SUMO-interacting motif in ICP0 (SIM-like sequence [SLS] 4) that is essential and sufficient to target SUMOylated proteins in PML NBs such as the PML and Sp100. We shown that phosphorylation of SLS4 creates new salt bridges between SUMO and SLS4, increases the SUMO/SLS4 affinity, and switches ICP0 into a potent STUbL. HSV activates the Ataxia-telangiectasia-mutated kinase-Checkpoint kinase 2 (ATM-Chk2) pathway to regulate the cell cycle of the host. We report that the activated Chk2 also phosphorylates ICP0 at SLS4 and enhances its STUbL activity. Our results uncover that a viral STUbL counters antiviral response by exploiting an unprecedented cross-talk of three post-translational modifications: ubiquitination, SUMOylation, and phosphorylation.
		+
		+	The Viral SUMO-Targeted Ubiquitin Ligase ICP0 is Phosphorylated and Activated by Host Kinase Chk2.,Hembram DSS, Negi H, Biswas P, Tripathi V, Bhushan L, Shet D, Kumar V, Das R J Mol Biol. 2020 Jan 27. pii: S0022-2836(20)30073-5. doi:, 10.1016/j.jmb.2020.01.021. PMID:32001251<ref>PMID:32001251</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6jxu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[SUMO 3D Structures\|SUMO 3D Structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Das, R]]		[[Category: Das, R]]

OCA at 07:58, 5 February 2020

OCA — Wed, 05 Feb 2020 07:58:58 GMT

←Older revision		Revision as of 07:58, 5 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6jxu is ~~ON HOLD until Paper Publication~~	+	==SUMO1 bound to SLS4-SIM peptide from ICP0==
-		+	<StructureSection load='6jxu' size='340' side='right'caption='[[6jxu]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6jxu]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JXU FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jxu OCA], [http://pdbe.org/6jxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jxu RCSB], [http://www.ebi.ac.uk/pdbsum/6jxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jxu ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Das, R]]
		+	[[Category: Hembram, D S.S]]
		+	[[Category: Negi, H]]
		+	[[Category: Shet, D]]
		+	[[Category: Protein binding-peptide complex]]
		+	[[Category: Sumoylation]]

OCA at 04:22, 29 May 2019

OCA — Wed, 29 May 2019 04:22:07 GMT

←Older revision		Revision as of 04:22, 29 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6jxu is ON HOLD	+	The entry 6jxu is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6jxu" [edit=sysop:move=sysop]

OCA — Wed, 01 May 2019 07:00:54 GMT

Protected "6jxu" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:00, 1 May 2019

OCA: New page: '''Unreleased structure''' The entry 6jxu is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 01 May 2019 07:00:53 GMT

New page: '''Unreleased structure''' The entry 6jxu is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6jxu is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]