6jyv - Revision history

OCA at 10:22, 22 November 2023

OCA — Wed, 22 Nov 2023 10:22:05 GMT

←Older revision		Revision as of 10:22, 22 November 2023
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	<StructureSection load='6jyv' size='340' side='right'caption='[[6jyv]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='6jyv' size='340' side='right'caption='[[6jyv]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jyv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JYV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6JYV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jyv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JYV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.651Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PA4191 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=208964 PSEAE])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6jyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jyv OCA], [~~http~~://pdbe.org/6jyv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jyv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jyv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jyv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jyv OCA], [https://pdbe.org/6jyv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jyv RCSB], [https://www.ebi.ac.uk/pdbsum/6jyv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jyv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9HWJ0_PSEAE Q9HWJ0_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Bartlam, M]]	+	[[Category: Bartlam M]]
-	[[Category: Che, S]]	+	[[Category: Che S]]
-	[[Category: Hao, Z]]	+	[[Category: Hao Z]]
-	[[Category: Liu, R]]	+	[[Category: Liu R]]
-	[[Category: Wang, R]]	+	[[Category: Wang R]]
-	[[Category: Zhang, Q]]	+	[[Category: Zhang Q]]
-	~~[[Category: Beta-lactam antibiotic synthesis]]~~	+
-	~~[[Category: Iron binding]]~~	+
-	~~[[Category: Isopenicillin n synthase]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 06:37, 29 May 2019

OCA — Wed, 29 May 2019 06:37:17 GMT

←Older revision		Revision as of 06:37, 29 May 2019
Line 3:		Line 3:
	<StructureSection load='6jyv' size='340' side='right'caption='[[6jyv]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='6jyv' size='340' side='right'caption='[[6jyv]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jyv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JYV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JYV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jyv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JYV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JYV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA4191 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jyv OCA], [http://pdbe.org/6jyv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jyv RCSB], [http://www.ebi.ac.uk/pdbsum/6jyv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jyv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jyv OCA], [http://pdbe.org/6jyv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jyv RCSB], [http://www.ebi.ac.uk/pdbsum/6jyv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jyv ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Isopenicillin N synthase (IPNS) is a nonheme-Fe(2+)-dependent enzyme that mediates a key step in penicillin biosynthesis. It catalyses the conversion of the tripeptide delta-(l-alpha-aminoadipoyl)-l-cysteine-d-valine (ACV) to isopenicillin N, which is a key precursor to beta-lactam antibiotics. The pa4191 gene in Pseudomonas aeruginosa PAO1 has provisionally been annotated as a member of the IPNS family. In this work, we report the crystal structure of PA4191 from P. aeruginosa (PaIPNS hereafter). The 1.65A resolution PaIPNS structure forms a jelly roll fold and is confirmed to be a member of the IPNS family based on structural homology. A metal centre within the jelly roll consists of the strictly conserved His201, Asp203 and His257 residues. MicroScale Thermophoresis binding analysis confirms that PaIPNS is a metal-binding protein with a strong preference for iron, but that it does not bind the tripeptide ACV. Structural comparison of PaIPNS with a previously reported IPNS-ACV complex structure reveals a restricted binding pocket that is unable to accommodate ACV.
		+
		+	Structural characterization of an isopenicillin N synthase family oxygenase from Pseudomonas aeruginosa PAO1.,Zhang H, Che S, Wang R, Liu R, Zhang Q, Bartlam M Biochem Biophys Res Commun. 2019 May 13. pii: S0006-291X(19)30932-5. doi:, 10.1016/j.bbrc.2019.05.062. PMID:31097228<ref>PMID:31097228</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6jyv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Pseae]]
	[[Category: Bartlam, M]]		[[Category: Bartlam, M]]
	[[Category: Che, S]]		[[Category: Che, S]]

OCA at 06:51, 23 May 2019

OCA — Thu, 23 May 2019 06:51:19 GMT

←Older revision		Revision as of 06:51, 23 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6jyv ~~is ON HOLD~~	+	==Structure of an isopenicillin N synthase from Pseudomonas aeruginosa PAO1==
-		+	<StructureSection load='6jyv' size='340' side='right'caption='[[6jyv]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6jyv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JYV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JYV FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jyv OCA], [http://pdbe.org/6jyv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jyv RCSB], [http://www.ebi.ac.uk/pdbsum/6jyv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jyv ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bartlam, M]]
		+	[[Category: Che, S]]
		+	[[Category: Hao, Z]]
		+	[[Category: Liu, R]]
		+	[[Category: Wang, R]]
		+	[[Category: Zhang, Q]]
		+	[[Category: Beta-lactam antibiotic synthesis]]
		+	[[Category: Iron binding]]
		+	[[Category: Isopenicillin n synthase]]
		+	[[Category: Metal binding protein]]

OCA: Protected "6jyv" [edit=sysop:move=sysop]

OCA — Fri, 10 May 2019 07:37:25 GMT

Protected "6jyv" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:37, 10 May 2019

OCA: New page: '''Unreleased structure''' The entry 6jyv is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Fri, 10 May 2019 07:37:23 GMT

New page: '''Unreleased structure''' The entry 6jyv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6jyv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]