6jz7 - Revision history

OCA at 10:22, 22 November 2023

OCA — Wed, 22 Nov 2023 10:22:15 GMT

←Older revision		Revision as of 10:22, 22 November 2023
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	<StructureSection load='6jz7' size='340' side='right'caption='[[6jz7]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='6jz7' size='340' side='right'caption='[[6jz7]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6jz7]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_29149 Atcc 29149~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZ7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6JZ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jz7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ruminococcus_gnavus Ruminococcus gnavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JZ7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CKU:(3~{S},4~{R},5~{R})-4,5-bis(oxidanyl)-1-propyl-piperidine-3-carboxylic+acid'>CKU</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uidA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33038 ATCC 29149])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CKU:(3~{S},4~{R},5~{R})-4,5-bis(oxidanyl)-1-propyl-piperidine-3-carboxylic+acid'>CKU</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6jz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jz7 OCA], [~~http~~://pdbe.org/6jz7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6jz7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6jz7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6jz7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jz7 OCA], [https://pdbe.org/6jz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jz7 RCSB], [https://www.ebi.ac.uk/pdbsum/6jz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jz7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6W7J7_RUMGN Q6W7J7_RUMGN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6jz7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6jz7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galactosidase 3D structures\|Galactosidase 3D structures]]
		+	*[[Glucuronisidase 3D structures\|Glucuronisidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 29149]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dashnyam, P]]	+	[[Category: Dashnyam P]]
-	[[Category: Lin~~, H Y]]~~	+	[[Category: Lin HY]]
-	~~[[Category: B-glucuronidase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 10:47, 24 December 2020

OCA — Thu, 24 Dec 2020 10:47:01 GMT

←Older revision		Revision as of 10:47, 24 December 2020
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	==b-glucuronidase from Ruminococcus gnavus in complex with N1-substituted uronic isofagomine==		==b-glucuronidase from Ruminococcus gnavus in complex with N1-substituted uronic isofagomine==
-	<StructureSection load='6jz7' size='340' side='right'caption='[[6jz7]]' scene=''>	+	<StructureSection load='6jz7' size='340' side='right'caption='[[6jz7]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JZ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6jz7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_29149 Atcc 29149]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JZ7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jz7 OCA], [http://pdbe.org/6jz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jz7 RCSB], [http://www.ebi.ac.uk/pdbsum/6jz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jz7 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CKU:(3~{S},4~{R},5~{R})-4,5-bis(oxidanyl)-1-propyl-piperidine-3-carboxylic+acid'>CKU</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">uidA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33038 ATCC 29149])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jz7 OCA], [http://pdbe.org/6jz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jz7 RCSB], [http://www.ebi.ac.uk/pdbsum/6jz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jz7 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Selective inhibitors of gut bacterial beta-glucuronidases (GUSs) are of particular interest in the prevention of xenobiotic-induced toxicities. This study reports the first structure-activity relationships on potency and selectivity of several iminocyclitols (2-7) for the GUSs. Complex structures of Ruminococcus gnavus GUS with 2-7 explained how charge, conformation, and substituent of iminocyclitols affect their potency and selectivity. N1 of uronic isofagomine (2) made strong electrostatic interactions with two catalytic glutamates of GUSs, resulting in the most potent inhibition (Ki >/= 11 nM). C6-propyl analogue of 2 (6) displayed 700-fold selectivity for opportunistic bacterial GUSs (Ki = 74 nM for E. coli GUS and 51.8 muM for RgGUS). In comparison with 2, there was 200-fold enhancement in the selectivity, which was attributed to differential interactions between the propyl group and loop 5 residues of the GUSs. The results provide useful insights to develop potent and selective inhibitors for undesired GUSs.
		+
		+	Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes.,Dashnyam P, Lin HY, Chen CY, Gao S, Yeh LF, Hsieh WC, Tu Z, Lin CH J Med Chem. 2020 May 14;63(9):4617-4627. doi: 10.1021/acs.jmedchem.9b01918. Epub , 2020 Mar 9. PMID:32105467<ref>PMID:32105467</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6jz7" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 29149]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dashnyam P]]	+	[[Category: Dashnyam, P]]
-	[[Category: Lin HY]]	+	[[Category: Lin, H Y]]
		+	[[Category: B-glucuronidase]]
		+	[[Category: Hydrolase]]

OCA at 06:22, 10 June 2020

OCA — Wed, 10 Jun 2020 06:22:13 GMT

←Older revision		Revision as of 06:22, 10 June 2020
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-	'''Unreleased structure'''

-	~~The entry 6jz7 is ON HOLD until Paper Publication~~	+	==b-glucuronidase from Ruminococcus gnavus in complex with N1-substituted uronic isofagomine==
-		+	<StructureSection load='6jz7' size='340' side='right'caption='[[6jz7]]' scene=''>
-	~~Authors: Dashnyam, P., Lin, H.Y.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JZ7 FirstGlance]. <br>
-	~~Description:~~ b-glucuronidase from Ruminococcus gnavus in complex with N1-substituted uronic isofagomine	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jz7 OCA], [http://pdbe.org/6jz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jz7 RCSB], [http://www.ebi.ac.uk/pdbsum/6jz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jz7 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Lin~~, H.Y]]	+	__TOC__
-	[[Category: Dashnyam, P]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Dashnyam P]]
		+	[[Category: Lin HY]]

OCA at 05:00, 27 November 2019

OCA — Wed, 27 Nov 2019 05:00:21 GMT

←Older revision		Revision as of 05:00, 27 November 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6jz7 is ON HOLD	+	The entry 6jz7 is ON HOLD until Paper Publication

	Authors: Dashnyam, P., Lin, H.Y.		Authors: Dashnyam, P., Lin, H.Y.

OCA: Protected "6jz7" [edit=sysop:move=sysop]

OCA — Fri, 10 May 2019 07:39:01 GMT

Protected "6jz7" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:39, 10 May 2019

OCA: New page: '''Unreleased structure''' The entry 6jz7 is ON HOLD Authors: Dashnyam, P., Lin, H.Y. Description: b-glucuronidase from Ruminococcus gnavus in complex with N1-substituted uronic isofag...

OCA — Fri, 10 May 2019 07:38:58 GMT

New page: '''Unreleased structure''' The entry 6jz7 is ON HOLD Authors: Dashnyam, P., Lin, H.Y. Description: b-glucuronidase from Ruminococcus gnavus in complex with N1-substituted uronic isofag...

New page

'''Unreleased structure'''

The entry 6jz7 is ON HOLD

Authors: Dashnyam, P., Lin, H.Y.

Description: b-glucuronidase from Ruminococcus gnavus in complex with N1-substituted uronic isofagomine
[[Category: Unreleased Structures]]
[[Category: Lin, H.Y]]
[[Category: Dashnyam, P]]