6k60 - Revision history

OCA at 10:27, 22 November 2023

OCA — Wed, 22 Nov 2023 10:27:06 GMT

←Older revision		Revision as of 10:27, 22 November 2023
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	<StructureSection load='6k60' size='340' side='right'caption='[[6k60]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='6k60' size='340' side='right'caption='[[6k60]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k60]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K60 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6K60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k60]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K60 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=IOD:IODIDE+ION'>IOD</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.149Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>HLA-G, HLA-6.0, HLAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]), LILRB1 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6k60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k60 OCA], [~~http~~://pdbe.org/6k60 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6k60 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6k60 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6k60 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k60 OCA], [https://pdbe.org/6k60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k60 RCSB], [https://www.ebi.ac.uk/pdbsum/6k60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k60 ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HLAG_HUMAN HLAG_HUMAN]] Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells~~. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system~~.	+	[https://www.uniprot.org/uniprot/HLAG_HUMAN HLAG_HUMAN] Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6k60" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6k60" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
		+	*[[Leukocyte immunoglobulin-like receptor\|Leukocyte immunoglobulin-like receptor]]
		+	*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fukunaga, A]]	+	[[Category: Fukunaga A]]
-	[[Category: Fukunaga, Y]]	+	[[Category: Fukunaga Y]]
-	[[Category: Hirose, K]]	+	[[Category: Hirose K]]
-	[[Category: Kamishikiryo, J]]	+	[[Category: Kamishikiryo J]]
-	[[Category: Kanda, R]]	+	[[Category: Kanda R]]
-	[[Category: Kita, S]]	+	[[Category: Kita S]]
-	[[Category: Kuroki, K]]	+	[[Category: Kuroki K]]
-	[[Category: Maenaka, K]]	+	[[Category: Maenaka K]]
-	[[Category: Matsubara, H]]	+	[[Category: Matsubara H]]
-	[[Category: Miyashita, N]]	+	[[Category: Miyashita N]]
-	[[Category: Ose, T]]	+	[[Category: Ose T]]
-	[[Category: Shiroishi, M]]	+	[[Category: Shiroishi M]]
-	[[Category: Sugita, Y]]	+	[[Category: Sugita Y]]
-	~~[[Category: Hla class i]]~~	+
-	~~[[Category: Hlag]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Lilrb1/ilt2~~]]	+

OCA at 12:58, 25 December 2019

OCA — Wed, 25 Dec 2019 12:58:01 GMT

←Older revision		Revision as of 12:58, 25 December 2019
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	<StructureSection load='6k60' size='340' side='right'caption='[[6k60]], [[Resolution\|resolution]] 3.15Å' scene=''>		<StructureSection load='6k60' size='340' side='right'caption='[[6k60]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k60]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k60]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K60 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-G, HLA-6.0, HLAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LILRB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k60 OCA], [http://pdbe.org/6k60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k60 RCSB], [http://www.ebi.ac.uk/pdbsum/6k60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k60 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k60 OCA], [http://pdbe.org/6k60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k60 RCSB], [http://www.ebi.ac.uk/pdbsum/6k60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k60 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Fukunaga, A]]		[[Category: Fukunaga, A]]

OCA at 06:47, 27 November 2019

OCA — Wed, 27 Nov 2019 06:47:46 GMT

←Older revision		Revision as of 06:47, 27 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6k60 is ~~ON HOLD~~ ~~until May 31 2021~~	+	==Structural and functional basis for HLA-G isoform recognition of immune checkpoint receptor LILRBs==
		+	<StructureSection load='6k60' size='340' side='right'caption='[[6k60]], [[Resolution\|resolution]] 3.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6k60]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K60 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k60 OCA], [http://pdbe.org/6k60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k60 RCSB], [http://www.ebi.ac.uk/pdbsum/6k60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k60 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HLAG_HUMAN HLAG_HUMAN]] Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human leukocyte Ig-like receptors (LILR) LILRB1 and LILRB2 are immune checkpoint receptors that regulate a wide range of physiological responses by binding to diverse ligands, including HLA-G. HLA-G is exclusively expressed in the placenta, some immunoregulatory cells, and tumors and has several unique isoforms. However, the recognition of HLA-G isoforms by LILRs is poorly understood. In this study, we characterized LILR binding to the beta2-microglobulin (beta2m)-free HLA-G1 isoform, which is synthesized by placental trophoblast cells and tends to dimerize and multimerize. The multimerized beta2m-free HLA-G1 dimer lacked detectable affinity for LILRB1, but bound strongly to LILRB2. We also determined the crystal structure of the LILRB1 and HLA-G1 complex, which adopted the typical structure of a classical HLA class I complex. LILRB1 exhibits flexible binding modes with the alpha3 domain, but maintains tight contacts with beta2m, thus accounting for beta2m-dependent binding. Notably, both LILRB1 and B2 are oriented at suitable angles to permit efficient signaling upon complex formation with HLA-G1 dimers. These structural and functional features of ligand recognition by LILRs provide novel insights into their important roles in the biological regulations.

-	~~Authors~~:	+	Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G Isoforms.,Kuroki K, Matsubara H, Kanda R, Miyashita N, Shiroishi M, Fukunaga Y, Kamishikiryo J, Fukunaga A, Fukuhara H, Hirose K, Hunt JS, Sugita Y, Kita S, Ose T, Maenaka K J Immunol. 2019 Nov 6. pii: jimmunol.1900562. doi: 10.4049/jimmunol.1900562. PMID:31694909<ref>PMID:31694909</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6k60" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Fukunaga, A]]
		+	[[Category: Fukunaga, Y]]
		+	[[Category: Hirose, K]]
		+	[[Category: Kamishikiryo, J]]
		+	[[Category: Kanda, R]]
		+	[[Category: Kita, S]]
		+	[[Category: Kuroki, K]]
		+	[[Category: Maenaka, K]]
		+	[[Category: Matsubara, H]]
		+	[[Category: Miyashita, N]]
		+	[[Category: Ose, T]]
		+	[[Category: Shiroishi, M]]
		+	[[Category: Sugita, Y]]
		+	[[Category: Hla class i]]
		+	[[Category: Hlag]]
		+	[[Category: Immune system]]
		+	[[Category: Lilrb1/ilt2]]

OCA at 04:57, 6 November 2019

OCA — Wed, 06 Nov 2019 04:57:10 GMT

←Older revision		Revision as of 04:57, 6 November 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6k60 is ON HOLD	+	The entry 6k60 is ON HOLD until May 31 2021

	Authors:		Authors:

OCA: Protected "6k60" [edit=sysop:move=sysop]

OCA — Wed, 12 Jun 2019 03:52:58 GMT

Protected "6k60" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:52, 12 June 2019

OCA: New page: '''Unreleased structure''' The entry 6k60 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Jun 2019 03:52:57 GMT

New page: '''Unreleased structure''' The entry 6k60 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6k60 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]