6k6m - Revision history

OCA at 10:27, 22 November 2023

OCA — Wed, 22 Nov 2023 10:27:27 GMT

←Older revision		Revision as of 10:27, 22 November 2023
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	<StructureSection load='6k6m' size='340' side='right'caption='[[6k6m]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='6k6m' size='340' side='right'caption='[[6k6m]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k6m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aids_virus Aids~~ virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K6M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k6m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K6M FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k6m OCA], [https://pdbe.org/6k6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k6m RCSB], [https://www.ebi.ac.uk/pdbsum/6k6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k6m ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.072Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k6m OCA], [https://pdbe.org/6k6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k6m RCSB], [https://www.ebi.ac.uk/pdbsum/6k6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k6m ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
-	*[[Protein Nef\|Protein Nef]]	+	*[[Protein Nef 3D structures\|Protein Nef 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aids~~ virus]]	+	[[Category: Human immunodeficiency virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Andrews, S]]	+	[[Category: Andrews S]]
-	[[Category: Hirao, K]]	+	[[Category: Hirao K]]
-	[[Category: Kita, S]]	+	[[Category: Kita S]]
-	[[Category: Kuroki, K]]	+	[[Category: Kuroki K]]
-	[[Category: Kusaka, H]]	+	[[Category: Kusaka H]]
-	[[Category: Maenaka, K]]	+	[[Category: Maenaka K]]
-	[[Category: Ose, T]]	+	[[Category: Ose T]]
-	[[Category: Rowland-Jones, S]]	+	[[Category: Rowland-Jones S]]
-	[[Category: Tadokoro, T]]	+	[[Category: Tadokoro T]]
-	~~[[Category: Accessory protein]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 08:27, 21 April 2021

OCA — Wed, 21 Apr 2021 08:27:00 GMT

←Older revision		Revision as of 08:27, 21 April 2021
Line 3:		Line 3:
	<StructureSection load='6k6m' size='340' side='right'caption='[[6k6m]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='6k6m' size='340' side='right'caption='[[6k6m]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k6m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K6M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6K6M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k6m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aids_virus Aids virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K6M FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k6m OCA], [~~http~~://pdbe.org/6k6m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6k6m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6k6m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6k6m ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k6m OCA], [https://pdbe.org/6k6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k6m RCSB], [https://www.ebi.ac.uk/pdbsum/6k6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k6m ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human immunodeficiency virus (HIV) accessory protein Nef plays a major role in establishing and maintaining infection, particularly through immune evasion. Many HIV-2-infected people experience long-term viral control and survival, resembling HIV-1 elite control. HIV-2 Nef has overlapping but also distinct functions from HIV-1 Nef. Here we report the crystal structure of HIV-2 Nef core. The di-leucine sorting motif forms a helix bound to neighboring molecules, and moreover, isothermal titration calorimetry demonstrated that the CD3 endocytosis motif can directly bind to HIV-2 Nef, ensuring AP-2-mediated endocytosis for CD3. The highly conserved C-terminal region forms a alpha-helix, absent from HIV-1. We further determined the structure of simian immunodeficiency virus (SIV) Nef harboring this region, demonstrating similar C-terminal alpha-helix, which may contribute to AP-1 binding for MHC-I downregulation. These results provide insights into the distinct pathogenesis of HIV-2 infection.
		+
		+	Structure of HIV-2 Nef Reveals Features Distinct from HIV-1 Involved in Immune Regulation.,Hirao K, Andrews S, Kuroki K, Kusaka H, Tadokoro T, Kita S, Ose T, Rowland-Jones SL, Maenaka K iScience. 2020 Jan 24;23(1):100758. doi: 10.1016/j.isci.2019.100758. Epub 2019, Dec 9. PMID:31927483<ref>PMID:31927483</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6k6m" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Protein Nef\|Protein Nef]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aids virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Andrews, S]]		[[Category: Andrews, S]]

OCA at 10:04, 27 March 2020

OCA — Fri, 27 Mar 2020 10:04:18 GMT

←Older revision		Revision as of 10:04, 27 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6k6m is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of HIV-2 Nef protein==
-		+	<StructureSection load='6k6m' size='340' side='right'caption='[[6k6m]], [[Resolution\|resolution]] 2.07Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6k6m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K6M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K6M FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k6m OCA], [http://pdbe.org/6k6m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k6m RCSB], [http://www.ebi.ac.uk/pdbsum/6k6m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k6m ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Andrews, S]]
		+	[[Category: Hirao, K]]
		+	[[Category: Kita, S]]
		+	[[Category: Kuroki, K]]
		+	[[Category: Kusaka, H]]
		+	[[Category: Maenaka, K]]
		+	[[Category: Ose, T]]
		+	[[Category: Rowland-Jones, S]]
		+	[[Category: Tadokoro, T]]
		+	[[Category: Accessory protein]]
		+	[[Category: Viral protein]]

OCA at 12:56, 29 January 2020

OCA — Wed, 29 Jan 2020 12:56:38 GMT

←Older revision		Revision as of 12:56, 29 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6k6m is ON HOLD	+	The entry 6k6m is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6k6m" [edit=sysop:move=sysop]

OCA — Wed, 12 Jun 2019 03:54:51 GMT

Protected "6k6m" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:54, 12 June 2019

OCA: New page: '''Unreleased structure''' The entry 6k6m is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Jun 2019 03:54:49 GMT

New page: '''Unreleased structure''' The entry 6k6m is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6k6m is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]