6k6u - Revision history

OCA at 10:27, 22 November 2023

OCA — Wed, 22 Nov 2023 10:27:33 GMT

←Older revision		Revision as of 10:27, 22 November 2023
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	<StructureSection load='6k6u' size='340' side='right'caption='[[6k6u]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='6k6u' size='340' side='right'caption='[[6k6u]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k6u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K6U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6K6U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k6u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K6U FirstGlance]. <br>
-	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~http://en.wikipedia.org/wiki/RNA_helicase RNA helicase~~]~~, with EC number [http://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.27Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6k6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k6u OCA], [~~http~~://pdbe.org/6k6u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6k6u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6k6u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6k6u ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k6u OCA], [https://pdbe.org/6k6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k6u RCSB], [https://www.ebi.ac.uk/pdbsum/6k6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k6u ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/YTDC2_HUMAN YTDC2_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: RNA helicase]]~~	+	[[Category: Liao S]]
-	[[Category: Liao, S]]	+	[[Category: Ma C]]
-	[[Category: Ma, C]]	+	[[Category: Xu C]]
-	[[Category: Xu, C]]	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: M6a]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Yth]]~~	+
-	~~[[Category: Ythdc2~~]]	+

OCA at 09:04, 25 December 2019

OCA — Wed, 25 Dec 2019 09:04:21 GMT

←Older revision		Revision as of 09:04, 25 December 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6k6u is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the human YTHDC2 YTH domain==
		+	<StructureSection load='6k6u' size='340' side='right'caption='[[6k6u]], [[Resolution\|resolution]] 2.27Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6k6u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K6U FirstGlance]. <br>
		+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k6u OCA], [http://pdbe.org/6k6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k6u RCSB], [http://www.ebi.ac.uk/pdbsum/6k6u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k6u ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N(6)-methyladenosine (m(6)A) "readers" play an important role in mRNA functions and metabolism. YTHDC2, as one of the m(6)A readers, controls fertileness through decreasing associated mRNA abundance and enhancing the translation efficiency of related mRNA via binding the targeted m(6)A RNA. However, how YTH domain of YTHDC2 recognize m(6)A RNA is still unknown. In this study, we determined the crystal structure of human YTHDC2 YTH domain, which adopts similar architecture to other solved YTH domain structures. YTHDC2 contains a conserved m(6)A binding pocket, and similar RNA binding surface shared by YTHDC1.

-	~~Authors~~:	+	Crystal structure of human YTHDC2 YTH domain.,Ma C, Liao S, Zhu Z Biochem Biophys Res Commun. 2019 Oct 22;518(4):678-684. doi:, 10.1016/j.bbrc.2019.08.107. Epub 2019 Aug 28. PMID:31472957<ref>PMID:31472957</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6k6u" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: RNA helicase]]
		+	[[Category: Liao, S]]
		+	[[Category: Ma, C]]
		+	[[Category: Xu, C]]
		+	[[Category: Hydrolase]]
		+	[[Category: M6a]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomic]]
		+	[[Category: Yth]]
		+	[[Category: Ythdc2]]

OCA at 07:14, 30 October 2019

OCA — Wed, 30 Oct 2019 07:14:47 GMT

←Older revision		Revision as of 07:14, 30 October 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6k6u is ON HOLD	+	The entry 6k6u is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6k6u" [edit=sysop:move=sysop]

OCA — Wed, 12 Jun 2019 03:55:29 GMT

Protected "6k6u" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:55, 12 June 2019

OCA: New page: '''Unreleased structure''' The entry 6k6u is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Jun 2019 03:55:28 GMT

New page: '''Unreleased structure''' The entry 6k6u is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6k6u is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]