6k7o - Revision history

OCA at 10:27, 22 November 2023

OCA — Wed, 22 Nov 2023 10:27:46 GMT

←Older revision		Revision as of 10:27, 22 November 2023
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	<StructureSection load='6k7o' size='340' side='right'caption='[[6k7o]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6k7o' size='340' side='right'caption='[[6k7o]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k7o]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K7O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6K7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k7o]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K7O FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~LILRB4~~, ~~ILT3, LIR5 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.004Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6k7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k7o OCA], [~~http~~://pdbe.org/6k7o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6k7o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6k7o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6k7o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k7o OCA], [https://pdbe.org/6k7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k7o RCSB], [https://www.ebi.ac.uk/pdbsum/6k7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k7o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LIRB4_HUMAN LIRB4_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:11875462</ref> <ref>PMID:9151699</ref>	+	[https://www.uniprot.org/uniprot/LIRB4_HUMAN LIRB4_HUMAN] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:11875462</ref> <ref>PMID:9151699</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6k7o" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6k7o" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Leukocyte immunoglobulin-like receptor\|Leukocyte immunoglobulin-like receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chai, Y]]	+	[[Category: Chai Y]]
-	[[Category: Gao~~, F G~~]]	+	[[Category: Gao FG]]
-	[[Category: Song, H]]	+	[[Category: Song H]]
-	[[Category: Xu, X]]	+	[[Category: Xu X]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immune therapy]]~~	+
-	~~[[Category: Lilrb4~~]]	+

OCA at 17:23, 14 August 2019

OCA — Wed, 14 Aug 2019 17:23:38 GMT

←Older revision		Revision as of 17:23, 14 August 2019
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	<StructureSection load='6k7o' size='340' side='right'caption='[[6k7o]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6k7o' size='340' side='right'caption='[[6k7o]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k7o]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K7O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k7o]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K7O FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k7o OCA], [http://pdbe.org/6k7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k7o RCSB], [http://www.ebi.ac.uk/pdbsum/6k7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k7o ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LILRB4, ILT3, LIR5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k7o OCA], [http://pdbe.org/6k7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k7o RCSB], [http://www.ebi.ac.uk/pdbsum/6k7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k7o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chai, Y]]		[[Category: Chai, Y]]

OCA at 05:52, 3 July 2019

OCA — Wed, 03 Jul 2019 05:52:24 GMT

←Older revision		Revision as of 05:52, 3 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6k7o is ~~ON HOLD~~	+	==Complex structure of LILRB4 and h128-3 antibody==
		+	<StructureSection load='6k7o' size='340' side='right'caption='[[6k7o]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6k7o]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K7O FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k7o OCA], [http://pdbe.org/6k7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k7o RCSB], [http://www.ebi.ac.uk/pdbsum/6k7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k7o ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LIRB4_HUMAN LIRB4_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:11875462</ref> <ref>PMID:9151699</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Therapeutic strategies are urgently needed for patients with acute myeloid leukemia (AML). Leukocyte immunoglobulin-like receptor B4 (LILRB4), which suppresses T-cell activation and supports tissue infiltration of AML cells, represents an attractive drug target for anti-AML therapeutics. Here, we report the identification and development of an LILRB4-specific humanized mAb that blocks LILRB4 activation. This mAb, h128-3, showed potent activity in blocking the development of monocytic AML in various models including patient-derived xenograft mice and syngeneic immunocompetent AML mice. MAb h128-3 enhanced the anti-AML efficacy of chemotherapy treatment by stimulating mobilization of leukemia cells. Mechanistic studies revealed four concordant modes of action for the anti-AML activity of h128-3: (i) reversal of T-cell suppression, (ii) inhibition of monocytic AML cell tissue infiltration, (iii) antibody-dependent cellular cytotoxicity, and (iv) antibody-dependent cellular phagocytosis. Therefore, targeting LILRB4 with antibody represents an effective therapeutic strategy for treating monocytic AML.

-	~~Authors:~~ Song, H., Chai, Y., Xu, X., Gao, F.G.	+	Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development.,Gui X, Deng M, Song H, Chen Y, Xie J, Li Z, He L, Huang F, Xu Y, Anami Y, Yu H, Yu C, Li L, Yuan Z, Xu X, Wang Q, Chai Y, Huang T, Shi Y, Tsuchikama K, Liao XC, Xia N, Gao GF, Zhang N, Zhang CC, An Z Cancer Immunol Res. 2019 Jun 18. pii: 2326-6066.CIR-19-0036. doi:, 10.1158/2326-6066.CIR-19-0036. PMID:31213474<ref>PMID:31213474</ref>

-	~~Description: Complex structure~~ of ~~LILRB4 and h128~~-~~3 antibody~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Gao, F.G]]	+	<div class="pdbe-citations 6k7o" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chai, Y]]
		+	[[Category: Gao, F G]]
	[[Category: Song, H]]		[[Category: Song, H]]
	[[Category: Xu, X]]		[[Category: Xu, X]]
-	[[Category: ~~Chai, Y~~]]	+	[[Category: Antibody]]
		+	[[Category: Immune system]]
		+	[[Category: Immune therapy]]
		+	[[Category: Lilrb4]]

OCA: Protected "6k7o" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2019 04:04:27 GMT

Protected "6k7o" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:04, 19 June 2019

OCA: New page: '''Unreleased structure''' The entry 6k7o is ON HOLD Authors: Song, H., Chai, Y., Xu, X., Gao, F.G. Description: Complex structure of LILRB4 and h128-3 antibody [[Category: Unreleased ...

OCA — Wed, 19 Jun 2019 04:04:25 GMT

New page: '''Unreleased structure''' The entry 6k7o is ON HOLD Authors: Song, H., Chai, Y., Xu, X., Gao, F.G. Description: Complex structure of LILRB4 and h128-3 antibody [[Category: Unreleased ...

New page

'''Unreleased structure'''

The entry 6k7o is ON HOLD

Authors: Song, H., Chai, Y., Xu, X., Gao, F.G.

Description: Complex structure of LILRB4 and h128-3 antibody
[[Category: Unreleased Structures]]
[[Category: Gao, F.G]]
[[Category: Song, H]]
[[Category: Xu, X]]
[[Category: Chai, Y]]