6k7t - Revision history

OCA at 10:27, 22 November 2023

OCA — Wed, 22 Nov 2023 10:27:51 GMT

←Older revision		Revision as of 10:27, 22 November 2023
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	<StructureSection load='6k7t' size='340' side='right'caption='[[6k7t]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6k7t' size='340' side='right'caption='[[6k7t]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k7t]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Black_flying_fox Black flying fox~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K7T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6K7T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k7t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hendra_henipavirus Hendra henipavirus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pteropus_alecto Pteropus alecto]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K7T FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Ptal~~-~~N (~~[~~http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9402 Black flying fox~~]~~), B2M ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6k7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k7t OCA], [~~http~~://pdbe.org/6k7t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6k7t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6k7t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6k7t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k7t OCA], [https://pdbe.org/6k7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k7t RCSB], [https://www.ebi.ac.uk/pdbsum/6k7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k7t ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~B2MG_HUMAN B2MG_HUMAN~~]~~] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.~~	+	[https://www.uniprot.org/uniprot/A0A125R585_PTEAL A0A125R585_PTEAL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6k7t" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6k7t" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
		+	*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Black flying fox~~]]	+	[[Category: Hendra henipavirus]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chai, Y]]	+	[[Category: Pteropus alecto]]
-	[[Category: Cheng, H]]	+	[[Category: Chai Y]]
-	[[Category: Gao~~, F G~~]]	+	[[Category: Cheng H]]
-	[[Category: Liu~~, K F~~]]	+	[[Category: Gao FG]]
-	[[Category: Liu~~, W J~~]]	+	[[Category: Liu KF]]
-	[[Category: Lu, D]]	+	[[Category: Liu WJ]]
-	[[Category: Lu, Q]]	+	[[Category: Lu D]]
-	[[Category: Qi~~, J X~~]]	+	[[Category: Lu Q]]
-	[[Category: Yue, C]]	+	[[Category: Qi JX]]
-	[[Category: Zhang, D]]	+	[[Category: Yue C]]
-	~~[[Category: Immune molecular]]~~	+	[[Category: Zhang D]]
-	~~[[Category: Immune system~~]]	+

OCA at 10:20, 4 December 2019

OCA — Wed, 04 Dec 2019 10:20:20 GMT

←Older revision		Revision as of 10:20, 4 December 2019
Line 1:		Line 1:

-	==~~Crysral~~ structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Hendra virus-derived peptide HeV1--human beta-2 microglobulin==	+	==Crystal structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Hendra virus-derived peptide HeV1--human beta-2 microglobulin==
	<StructureSection load='6k7t' size='340' side='right'caption='[[6k7t]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6k7t' size='340' side='right'caption='[[6k7t]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6k7t]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K7T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6k7t]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Black_flying_fox Black flying fox] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K7T FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k7t OCA], [http://pdbe.org/6k7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k7t RCSB], [http://www.ebi.ac.uk/pdbsum/6k7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k7t ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptal-N ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9402 Black flying fox]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k7t OCA], [http://pdbe.org/6k7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k7t RCSB], [http://www.ebi.ac.uk/pdbsum/6k7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k7t ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Black flying fox]]
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chai, Y]]		[[Category: Chai, Y]]

OCA at 06:40, 6 November 2019

OCA — Wed, 06 Nov 2019 06:40:53 GMT

←Older revision		Revision as of 06:40, 6 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6k7t is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crysral structure of bat (Pteropus Alecto) MHC class I Ptal-N*01:01 in complex with Hendra virus-derived peptide HeV1--human beta-2 microglobulin==
		+	<StructureSection load='6k7t' size='340' side='right'caption='[[6k7t]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6k7t]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K7T FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k7t OCA], [http://pdbe.org/6k7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k7t RCSB], [http://www.ebi.ac.uk/pdbsum/6k7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k7t ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bats harbor many zoonotic viruses, including highly pathogenic viruses of humans and other mammals, but they are typically asymptomatic in bats. To further understand the antiviral immunity of bats, we screened and identified a series of bat major histocompatibility complex (MHC) I Ptal-N01:01-binding peptides derived from four different bat-borne viruses, i.e., Hendra virus (HeV), Ebola virus (EBOV), Middle East respiratory syndrome coronavirus (MERS-CoV), and H17N10 influenza-like virus. The structures of Ptal-N01:01 display unusual peptide presentation features in that the bat-specific 3-amino acid (aa) insertion enables the tight "surface anchoring" of the P1-Asp in pocket A of bat MHC I. As the classical primary anchoring positions, the B and F pockets of Ptal-N*01:01 also show unconventional conformations, which contribute to unusual peptide motifs and distinct peptide presentation. Notably, the features of bat MHC I may be shared by MHC I from various marsupials. Our study sheds light on bat adaptive immunity and may benefit future vaccine development against bat-borne viruses of high impact on humans.

-	~~Authors~~:	+	Peptide presentation by bat MHC class I provides new insight into the antiviral immunity of bats.,Lu D, Liu K, Zhang D, Yue C, Lu Q, Cheng H, Wang L, Chai Y, Qi J, Wang LF, Gao GF, Liu WJ PLoS Biol. 2019 Sep 9;17(9):e3000436. doi: 10.1371/journal.pbio.3000436., eCollection 2019 Sep. PMID:31498797<ref>PMID:31498797</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6k7t" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chai, Y]]
		+	[[Category: Cheng, H]]
		+	[[Category: Gao, F G]]
		+	[[Category: Liu, K F]]
		+	[[Category: Liu, W J]]
		+	[[Category: Lu, D]]
		+	[[Category: Lu, Q]]
		+	[[Category: Qi, J X]]
		+	[[Category: Yue, C]]
		+	[[Category: Zhang, D]]
		+	[[Category: Immune molecular]]
		+	[[Category: Immune system]]

OCA at 07:14, 30 October 2019

OCA — Wed, 30 Oct 2019 07:14:55 GMT

←Older revision		Revision as of 07:14, 30 October 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6k7t is ON HOLD	+	The entry 6k7t is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6k7t" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2019 04:04:53 GMT

Protected "6k7t" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:04, 19 June 2019

OCA: New page: '''Unreleased structure''' The entry 6k7t is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Jun 2019 04:04:51 GMT

New page: '''Unreleased structure''' The entry 6k7t is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6k7t is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]