6kag - Revision history

OCA at 10:42, 27 March 2024

OCA — Wed, 27 Mar 2024 10:42:03 GMT

←Older revision		Revision as of 10:42, 27 March 2024
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-	====	+	==Crystal structure of the SMARCB1/SMARCC2 subcomplex==
-	<StructureSection load='6kag' size='340' side='right'caption='[[6kag]]' scene=''>	+	<StructureSection load='6kag' size='340' side='right'caption='[[6kag]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kag]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KAG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6kag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kag OCA], [~~http~~://pdbe.org/6kag PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6kag RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6kag PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6kag ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.601Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kag OCA], [https://pdbe.org/6kag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kag RCSB], [https://www.ebi.ac.uk/pdbsum/6kag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kag ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/SNF5_HUMAN SNF5_HUMAN] Neurofibromatosis type 3;Atypical teratoid rhabdoid tumor;Familial rhabdoid tumor;Familial multiple meningioma;Coffin-Siris syndrome. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SNF5_HUMAN SNF5_HUMAN] Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.<ref>PMID:10078207</ref> <ref>PMID:12226744</ref> <ref>PMID:14604992</ref> <ref>PMID:16267391</ref> <ref>PMID:16314535</ref> <ref>PMID:9448295</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Chen G]]
		+	[[Category: Giancotti FG]]
		+	[[Category: Long J]]
		+	[[Category: Zhou H]]

OCA at 11:07, 23 September 2020

OCA — Wed, 23 Sep 2020 11:07:41 GMT

←Older revision		Revision as of 11:07, 23 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6kag ~~is ON HOLD until Sep 22 2021~~	+	====
-		+	<StructureSection load='6kag' size='340' side='right'caption='[[6kag]]' scene=''>
-	~~Authors~~: ~~Chen, G~~.~~, Zhou, H~~.~~, Giancotti, F~~.G.~~, Long, J~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of the SMARCB1~~/~~SMARCC2 subcomplex~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kag OCA], [http://pdbe.org/6kag PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kag RCSB], [http://www.ebi.ac.uk/pdbsum/6kag PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kag ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Zhou, H~~]]	+	__TOC__
-	[~~[Category~~: ~~Chen, G~~]]	+	</StructureSection>
-	[[Category: ~~Long, J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Giancotti, F.G~~]]	+	[[Category: Z-disk]]

OCA at 04:34, 27 May 2020

OCA — Wed, 27 May 2020 04:34:06 GMT

←Older revision		Revision as of 04:34, 27 May 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6kag is ON HOLD until ~~Paper Publication~~	+	The entry 6kag is ON HOLD until Sep 22 2021

	Authors: Chen, G., Zhou, H., Giancotti, F.G., Long, J.		Authors: Chen, G., Zhou, H., Giancotti, F.G., Long, J.
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	Description: Crystal structure of the SMARCB1/SMARCC2 subcomplex		Description: Crystal structure of the SMARCB1/SMARCC2 subcomplex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Zhou, H]]
	[[Category: Chen, G]]		[[Category: Chen, G]]
	[[Category: Long, J]]		[[Category: Long, J]]
-	[[Category: Zhou, H]]
	[[Category: Giancotti, F.G]]		[[Category: Giancotti, F.G]]

OCA at 08:39, 17 July 2019

OCA — Wed, 17 Jul 2019 08:39:49 GMT

←Older revision		Revision as of 08:39, 17 July 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6kag is ON HOLD	+	The entry 6kag is ON HOLD until Paper Publication

	Authors: Chen, G., Zhou, H., Giancotti, F.G., Long, J.		Authors: Chen, G., Zhou, H., Giancotti, F.G., Long, J.

OCA: Protected "6kag" [edit=sysop:move=sysop]

OCA — Wed, 03 Jul 2019 04:04:06 GMT

Protected "6kag" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:04, 3 July 2019

OCA: New page: '''Unreleased structure''' The entry 6kag is ON HOLD Authors: Chen, G., Zhou, H., Giancotti, F.G., Long, J. Description: Crystal structure of the SMARCB1/SMARCC2 subcomplex [[Category:...

OCA — Wed, 03 Jul 2019 04:04:05 GMT

New page: '''Unreleased structure''' The entry 6kag is ON HOLD Authors: Chen, G., Zhou, H., Giancotti, F.G., Long, J. Description: Crystal structure of the SMARCB1/SMARCC2 subcomplex [[Category:...

New page

'''Unreleased structure'''

The entry 6kag is ON HOLD

Authors: Chen, G., Zhou, H., Giancotti, F.G., Long, J.

Description: Crystal structure of the SMARCB1/SMARCC2 subcomplex
[[Category: Unreleased Structures]]
[[Category: Chen, G]]
[[Category: Long, J]]
[[Category: Zhou, H]]
[[Category: Giancotti, F.G]]