6kio - Revision history

OCA at 02:24, 11 April 2020

OCA — Sat, 11 Apr 2020 02:24:46 GMT

←Older revision		Revision as of 02:24, 11 April 2020
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	<SX load='6kio' size='340' side='right' viewer='molstar' caption='[[6kio]], [[Resolution\|resolution]] 3.94Å' scene=''>		<SX load='6kio' size='340' side='right' viewer='molstar' caption='[[6kio]], [[Resolution\|resolution]] 3.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kio]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KIO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6KIO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kio]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KIO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KIO FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYN1, DHC1, YKR054C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYN1, DHC1, YKR054C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6kio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kio OCA], [http://pdbe.org/6kio PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kio RCSB], [http://www.ebi.ac.uk/pdbsum/6kio PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kio ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kio OCA], [http://pdbe.org/6kio PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kio RCSB], [http://www.ebi.ac.uk/pdbsum/6kio PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kio ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 6kio" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6kio" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:52, 11 March 2020

OCA — Wed, 11 Mar 2020 07:52:43 GMT

←Older revision		Revision as of 07:52, 11 March 2020
Line 3:		Line 3:
	<SX load='6kio' size='340' side='right' viewer='molstar' caption='[[6kio]], [[Resolution\|resolution]] 3.94Å' scene=''>		<SX load='6kio' size='340' side='right' viewer='molstar' caption='[[6kio]], [[Resolution\|resolution]] 3.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kio]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KIO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kio]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KIO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kio OCA], [http://pdbe.org/6kio PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kio RCSB], [http://www.ebi.ac.uk/pdbsum/6kio PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kio ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DYN1, DHC1, YKR054C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kio OCA], [http://pdbe.org/6kio PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kio RCSB], [http://www.ebi.ac.uk/pdbsum/6kio PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kio ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TBB_PIG TBB_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/DYHC_YEAST DYHC_YEAST]] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.<ref>PMID:15642746</ref>		[[http://www.uniprot.org/uniprot/TBB_PIG TBB_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/DYHC_YEAST DYHC_YEAST]] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.<ref>PMID:15642746</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The movements of cytoplasmic dynein on microtubule (MT) tracks is achieved by two-way communication between the microtubule-binding domain (MTBD) and the ATPase domain via a coiled-coil stalk, but the structural basis of this communication remains elusive. Here, we regulate MTBD either in high-affinity or low-affinity states by introducing a disulfide bond to the stalk and analyze the resulting structures by NMR and cryo-EM. In the MT-unbound state, the affinity changes of MTBD are achieved by sliding of the stalk alpha-helix by a half-turn, which suggests that structural changes propagate from the ATPase-domain to MTBD. In addition, MT binding induces further sliding of the stalk alpha-helix even without the disulfide bond, suggesting how the MT-induced conformational changes propagate toward the ATPase domain. Based on differences in the MT-binding surface between the high- and low-affinity states, we propose a potential mechanism for the directional bias of dynein movement on MT tracks.
		+
		+	Structural basis for two-way communication between dynein and microtubules.,Nishida N, Komori Y, Takarada O, Watanabe A, Tamura S, Kubo S, Shimada I, Kikkawa M Nat Commun. 2020 Feb 25;11(1):1038. doi: 10.1038/s41467-020-14842-8. PMID:32098965<ref>PMID:32098965</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6kio" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
		+	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA at 22:24, 6 March 2020

OCA — Fri, 06 Mar 2020 22:24:36 GMT

←Older revision		Revision as of 22:24, 6 March 2020
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	==Complex of yeast cytoplasmic dynein MTBD-High and MT without DTT==		==Complex of yeast cytoplasmic dynein MTBD-High and MT without DTT==
-	<~~StructureSection~~ load='6kio' size='340' side='right'caption='[[6kio]], [[Resolution\|resolution]] 3.94Å' scene=''>	+	<SX load='6kio' size='340' side='right' viewer='molstar' caption='[[6kio]], [[Resolution\|resolution]] 3.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6kio]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KIO FirstGlance]. <br>		<table><tr><td colspan='2'>[[6kio]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KIO FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA at 06:41, 4 March 2020

OCA — Wed, 04 Mar 2020 06:41:05 GMT

←Older revision		Revision as of 06:41, 4 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6kio ~~is ON HOLD until Paper Publication~~	+	==Complex of yeast cytoplasmic dynein MTBD-High and MT without DTT==
-		+	<StructureSection load='6kio' size='340' side='right'caption='[[6kio]], [[Resolution\|resolution]] 3.94Å' scene=''>
-	~~Authors~~: ~~Yuta~~, K., ~~Noritaka~~, N., ~~Ichio, S~~., ~~Masahide, K~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6kio]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KIO FirstGlance]. <br>
-	~~Description~~: ~~Complex~~ of ~~yeast cytoplasmic dynein MTBD~~-~~High~~ and ~~MT without DTT~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kio OCA], [http://pdbe.org/6kio PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kio RCSB], [http://www.ebi.ac.uk/pdbsum/6kio PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kio ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Masahide~~, K]]	+	== Function ==
-	[[Category: ~~Noritaka~~, N]]	+	[[http://www.uniprot.org/uniprot/TBB_PIG TBB_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/DYHC_YEAST DYHC_YEAST]] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.<ref>PMID:15642746</ref>
-	[[Category: ~~Ichio~~, S]]	+	== References ==
-	[[Category: ~~Yuta~~, K]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Sus scrofa]]
		+	[[Category: Kikkawa, M]]
		+	[[Category: Komori, Y]]
		+	[[Category: Nishida, N]]
		+	[[Category: Shimada, I]]
		+	[[Category: Motor protein-structural protein complex]]

OCA at 06:33, 2 October 2019

OCA — Wed, 02 Oct 2019 06:33:36 GMT

←Older revision		Revision as of 06:33, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6kio is ON HOLD	+	The entry 6kio is ON HOLD until Paper Publication

	Authors: Yuta, K., Noritaka, N., Ichio, S., Masahide, K.		Authors: Yuta, K., Noritaka, N., Ichio, S., Masahide, K.

OCA: Protected "6kio" [edit=sysop:move=sysop]

OCA — Wed, 24 Jul 2019 04:18:20 GMT

Protected "6kio" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:18, 24 July 2019

OCA: New page: '''Unreleased structure''' The entry 6kio is ON HOLD Authors: Yuta, K., Noritaka, N., Ichio, S., Masahide, K. Description: Complex of yeast cytoplasmic dynein MTBD-High and MT without ...

OCA — Wed, 24 Jul 2019 04:18:19 GMT

New page: '''Unreleased structure''' The entry 6kio is ON HOLD Authors: Yuta, K., Noritaka, N., Ichio, S., Masahide, K. Description: Complex of yeast cytoplasmic dynein MTBD-High and MT without ...

New page

'''Unreleased structure'''

The entry 6kio is ON HOLD

Authors: Yuta, K., Noritaka, N., Ichio, S., Masahide, K.

Description: Complex of yeast cytoplasmic dynein MTBD-High and MT without DTT
[[Category: Unreleased Structures]]
[[Category: Masahide, K]]
[[Category: Noritaka, N]]
[[Category: Ichio, S]]
[[Category: Yuta, K]]