6kn9 - Revision history

OCA at 10:37, 22 November 2023

OCA — Wed, 22 Nov 2023 10:37:36 GMT

←Older revision		Revision as of 10:37, 22 November 2023
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	<StructureSection load='6kn9' size='340' side='right'caption='[[6kn9]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='6kn9' size='340' side='right'caption='[[6kn9]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kn9]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KN9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6KN9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kn9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KN9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.302Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~IL18RAP, IL1R7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6kn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kn9 OCA], [~~http~~://pdbe.org/6kn9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6kn9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6kn9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6kn9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kn9 OCA], [https://pdbe.org/6kn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kn9 RCSB], [https://www.ebi.ac.uk/pdbsum/6kn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kn9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/I18RA_HUMAN I18RA_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6kn9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6kn9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liu~~, C C~~]]	+	[[Category: Liu CC]]
-	[[Category: Wu~~, D H]]~~	+	[[Category: Wu DH]]
-	~~[[Category: Antagonist]]~~	+
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Interleukin receptor~~]]	+

OCA at 07:53, 11 March 2020

OCA — Wed, 11 Mar 2020 07:53:22 GMT

←Older revision		Revision as of 07:53, 11 March 2020
Line 3:		Line 3:
	<StructureSection load='6kn9' size='340' side='right'caption='[[6kn9]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='6kn9' size='340' side='right'caption='[[6kn9]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kn9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KN9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kn9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KN9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL18RAP, IL1R7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kn9 OCA], [http://pdbe.org/6kn9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kn9 RCSB], [http://www.ebi.ac.uk/pdbsum/6kn9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kn9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kn9 OCA], [http://pdbe.org/6kn9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kn9 RCSB], [http://www.ebi.ac.uk/pdbsum/6kn9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kn9 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Liu, C C]]		[[Category: Liu, C C]]

OCA at 04:13, 13 February 2020

OCA — Thu, 13 Feb 2020 04:13:18 GMT

←Older revision		Revision as of 04:13, 13 February 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6kn9 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scFv==
		+	<StructureSection load='6kn9' size='340' side='right'caption='[[6kn9]], [[Resolution\|resolution]] 3.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6kn9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KN9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kn9 OCA], [http://pdbe.org/6kn9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kn9 RCSB], [http://www.ebi.ac.uk/pdbsum/6kn9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kn9 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The interleukin-18 subfamily belongs to the interleukin-1 family and plays an important role in modulating innate and adaptive immune responses. Dysregulation of IL-18 has been implicated in or correlated with numerous diseases, including inflammatory diseases, autoimmune disorders, and cancer. Thus, blockade of IL-18 signaling may offer therapeutic benefits in many pathological settings. Here, we report the development of synthetic human antibodies that target human IL-18Rbeta and block IL-18-mediated IFN-gamma secretion by inhibiting NF-kappaB and MAPK dependent pathways. The crystal structure of a potent antagonist antibody in complex with IL-18Rbeta revealed inhibition through an unexpected allosteric mechanism. Our findings offer a novel means for therapeutic intervention in the IL-18 pathway and may provide a new strategy for targeting cytokine receptors.

-	~~Authors~~:	+	A Synthetic Human Antibody Antagonizes IL-18Rbeta Signaling Through an Allosteric Mechanism.,Liu S, Miersch S, Li P, Bai B, Liu C, Qin W, Su J, Huang H, Pan J, Sidhu SS, Wu D J Mol Biol. 2020 Jan 15. pii: S0022-2836(20)30042-5. doi:, 10.1016/j.jmb.2020.01.012. PMID:31954129<ref>PMID:31954129</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6kn9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Liu, C C]]
		+	[[Category: Wu, D H]]
		+	[[Category: Antagonist]]
		+	[[Category: Antibody]]
		+	[[Category: Complex]]
		+	[[Category: Cytokine]]
		+	[[Category: Interleukin receptor]]

OCA at 06:35, 2 October 2019

OCA — Wed, 02 Oct 2019 06:35:24 GMT

←Older revision		Revision as of 06:35, 2 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6kn9 is ON HOLD	+	The entry 6kn9 is ON HOLD until Paper Publication

-	Authors: ~~Wu, D.H., Liu, C.C.~~	+	Authors:

-	Description: ~~Crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scFv~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Liu, C.C]]
-	[[Category: Wu, D.H]]

OCA: Protected "6kn9" [edit=sysop:move=sysop]

OCA — Wed, 14 Aug 2019 14:55:37 GMT

Protected "6kn9" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:55, 14 August 2019

OCA: New page: '''Unreleased structure''' The entry 6kn9 is ON HOLD Authors: Wu, D.H., Liu, C.C. Description: Crystal structure of human interleukin 18 receptor beta extracellular domain in complex w...

OCA — Wed, 14 Aug 2019 14:55:35 GMT

New page: '''Unreleased structure''' The entry 6kn9 is ON HOLD Authors: Wu, D.H., Liu, C.C. Description: Crystal structure of human interleukin 18 receptor beta extracellular domain in complex w...

New page

'''Unreleased structure'''

The entry 6kn9 is ON HOLD

Authors: Wu, D.H., Liu, C.C.

Description: Crystal structure of human interleukin 18 receptor beta extracellular domain in complex with an antagonistic scFv
[[Category: Unreleased Structures]]
[[Category: Liu, C.C]]
[[Category: Wu, D.H]]