6kny - Revision history

OCA at 19:27, 29 May 2024

OCA — Wed, 29 May 2024 19:27:37 GMT

←Older revision		Revision as of 19:27, 29 May 2024
Line 3:		Line 3:
	<StructureSection load='6kny' size='340' side='right'caption='[[6kny]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6kny' size='340' side='right'caption='[[6kny]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>~~[[6kny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Akkm8 Akkm8].~~ Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KNY FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Amuc_1100 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=349741 AKKM8])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kny OCA], [https://pdbe.org/6kny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kny RCSB], [https://www.ebi.ac.uk/pdbsum/6kny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kny ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kny OCA], [https://pdbe.org/6kny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kny RCSB], [https://www.ebi.ac.uk/pdbsum/6kny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kny ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Many human diseases, such as obesity and diabetes, show annual increases in prevalence and often involve intestinal microbes. One such probiotic bacterium, Akkermansia muciniphila, which was discovered a decade ago, has been reported to influence glucose homeostasis and to contribute to gut health. Amuc_1100, a functionally uncharacterized protein of A. muciniphila, was found to be a key active component in reducing the body weight of mice. Here, the crystal structure of Amuc_1100 (residues 31-317), referred to as Amuc_1100, is reported at 2.1 A resolution. Amuc_1100 has a similar fold to three proteins related to pilus formation, PilO, PilN and EpsL, indicating a similar function. Biochemical investigations further confirmed a monomeric state for the soluble region of Amuc_1100, which differs from the dimeric states of PilO, PilN and EpsL. This study provides a structural basis for the elucidation of the molecular mechanism of Amuc_1100.
-
-	Crystal structure of monomeric Amuc_1100 from Akkermansia muciniphila.,Mou L, Peng X, Chen Y, Xiao Q, Liao H, Liu M, Guo L, Liu Y, Zhang X, Deng D Acta Crystallogr F Struct Biol Commun. 2020 Apr 1;76(Pt 4):168-174. doi:, 10.1107/S2053230X20004124. Epub 2020 Apr 1. PMID:32254050<ref>PMID:32254050</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 6kny" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Akkm8]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Deng, D]]	+	[[Category: Deng D]]
-	[[Category: Mou~~, L Q~~]]	+	[[Category: Mou LQ]]
-	[[Category: Xiao~~, Q J]]~~	+	[[Category: Xiao QJ]]
-	~~[[Category: Protein]]~~	+
-	~~[[Category: Uncharacterized]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 11:44, 23 March 2022

OCA — Wed, 23 Mar 2022 11:44:45 GMT

←Older revision		Revision as of 11:44, 23 March 2022
Line 3:		Line 3:
	<StructureSection load='6kny' size='340' side='right'caption='[[6kny]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6kny' size='340' side='right'caption='[[6kny]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kny]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Akkm8 Akkm8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6KNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Akkm8 Akkm8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KNY FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Amuc_1100 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=349741 AKKM8])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Amuc_1100 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=349741 AKKM8])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6kny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kny OCA], [~~http~~://pdbe.org/6kny PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6kny RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6kny PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6kny ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kny OCA], [https://pdbe.org/6kny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kny RCSB], [https://www.ebi.ac.uk/pdbsum/6kny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kny ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:01, 22 April 2020

OCA — Wed, 22 Apr 2020 06:01:37 GMT

←Older revision		Revision as of 06:01, 22 April 2020
Line 1:		Line 1:

	==Structure of Amuc_1100 without transmembrane region from Akkermansia muciniphila==		==Structure of Amuc_1100 without transmembrane region from Akkermansia muciniphila==
-	<StructureSection load='6kny' size='340' side='right'caption='[[6kny]]' scene=''>	+	<StructureSection load='6kny' size='340' side='right'caption='[[6kny]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KNY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kny]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Akkm8 Akkm8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KNY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kny OCA], [http://pdbe.org/6kny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kny RCSB], [http://www.ebi.ac.uk/pdbsum/6kny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kny ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Amuc_1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=349741 AKKM8])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kny OCA], [http://pdbe.org/6kny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kny RCSB], [http://www.ebi.ac.uk/pdbsum/6kny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kny ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many human diseases, such as obesity and diabetes, show annual increases in prevalence and often involve intestinal microbes. One such probiotic bacterium, Akkermansia muciniphila, which was discovered a decade ago, has been reported to influence glucose homeostasis and to contribute to gut health. Amuc_1100, a functionally uncharacterized protein of A. muciniphila, was found to be a key active component in reducing the body weight of mice. Here, the crystal structure of Amuc_1100 (residues 31-317), referred to as Amuc_1100, is reported at 2.1 A resolution. Amuc_1100 has a similar fold to three proteins related to pilus formation, PilO, PilN and EpsL, indicating a similar function. Biochemical investigations further confirmed a monomeric state for the soluble region of Amuc_1100, which differs from the dimeric states of PilO, PilN and EpsL. This study provides a structural basis for the elucidation of the molecular mechanism of Amuc_1100.
		+
		+	Crystal structure of monomeric Amuc_1100 from Akkermansia muciniphila.,Mou L, Peng X, Chen Y, Xiao Q, Liao H, Liu M, Guo L, Liu Y, Zhang X, Deng D Acta Crystallogr F Struct Biol Commun. 2020 Apr 1;76(Pt 4):168-174. doi:, 10.1107/S2053230X20004124. Epub 2020 Apr 1. PMID:32254050<ref>PMID:32254050</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6kny" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Akkm8]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Deng D]]	+	[[Category: Deng, D]]
-	[[Category: Mou LQ]]	+	[[Category: Mou, L Q]]
-	[[Category: Xiao QJ]]	+	[[Category: Xiao, Q J]]
		+	[[Category: Protein]]
		+	[[Category: Uncharacterized]]
		+	[[Category: Unknown function]]

OCA at 06:51, 15 April 2020

OCA — Wed, 15 Apr 2020 06:51:48 GMT

←Older revision		Revision as of 06:51, 15 April 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6kny ~~is ON HOLD until Paper Publication~~	+	==Structure of Amuc_1100 without transmembrane region from Akkermansia muciniphila==
-		+	<StructureSection load='6kny' size='340' side='right'caption='[[6kny]]' scene=''>
-	~~Authors~~: ~~Mou~~, L.Q., ~~Xiao~~, Q.J., ~~Deng~~, D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KNY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KNY FirstGlance]. <br>
-	~~Description: Crystal structure of protein~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kny OCA], [http://pdbe.org/6kny PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kny RCSB], [http://www.ebi.ac.uk/pdbsum/6kny PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kny ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Deng, D]]	+	__TOC__
-	[[Category: ~~Xiao, Q.J~~]]	+	</StructureSection>
-	[[Category: ~~Mou, L.Q~~]]	+	[[Category: Large Structures]]
		+	[[Category: Deng D]]
		+	[[Category: Mou LQ]]
		+	[[Category: Xiao QJ]]

OCA at 07:03, 25 December 2019

OCA — Wed, 25 Dec 2019 07:03:09 GMT

←Older revision		Revision as of 07:03, 25 December 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6kny is ON HOLD	+	The entry 6kny is ON HOLD until Paper Publication

	Authors: Mou, L.Q., Xiao, Q.J., Deng, D.		Authors: Mou, L.Q., Xiao, Q.J., Deng, D.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Deng, D]]		[[Category: Deng, D]]
-	[[Category: Mou, L.Q]]
	[[Category: Xiao, Q.J]]		[[Category: Xiao, Q.J]]
		+	[[Category: Mou, L.Q]]

OCA: Protected "6kny" [edit=sysop:move=sysop]

OCA — Wed, 14 Aug 2019 14:57:46 GMT

Protected "6kny" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:57, 14 August 2019

OCA: New page: '''Unreleased structure''' The entry 6kny is ON HOLD Authors: Mou, L.Q., Xiao, Q.J., Deng, D. Description: Crystal structure of protein Category: Unreleased Structures [[Category: ...

OCA — Wed, 14 Aug 2019 14:57:45 GMT

New page: '''Unreleased structure''' The entry 6kny is ON HOLD Authors: Mou, L.Q., Xiao, Q.J., Deng, D. Description: Crystal structure of protein Category: Unreleased Structures [[Category: ...

New page

'''Unreleased structure'''

The entry 6kny is ON HOLD

Authors: Mou, L.Q., Xiao, Q.J., Deng, D.

Description: Crystal structure of protein
[[Category: Unreleased Structures]]
[[Category: Deng, D]]
[[Category: Mou, L.Q]]
[[Category: Xiao, Q.J]]