OCA at 10:43, 22 November 2023

OCA — Wed, 22 Nov 2023 10:43:49 GMT

←Older revision		Revision as of 10:43, 22 November 2023
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	==Crystal structure of fibroblast growth factor 19 in complex with Fab==		==Crystal structure of fibroblast growth factor 19 in complex with Fab==
-	<StructureSection load='6ktr' size='340' side='right'caption='[[6ktr]]' scene=''>	+	<StructureSection load='6ktr' size='340' side='right'caption='[[6ktr]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KTR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6KTR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ktr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KTR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KTR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ktr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ktr OCA], [~~http~~://pdbe.org/6ktr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ktr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ktr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ktr ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5977576Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ktr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ktr OCA], [https://pdbe.org/6ktr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ktr RCSB], [https://www.ebi.ac.uk/pdbsum/6ktr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ktr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FGF19_HUMAN FGF19_HUMAN] Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.<ref>PMID:12815072</ref> <ref>PMID:16597617</ref> <ref>PMID:17623664</ref> <ref>PMID:19085950</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hepatocellular carcinoma (HCC) is a common and particularly fatal form of cancer for which very few drugs are effective. The fibroblast growth factor 19 (FGF19) has been viewed as a driver of HCC development and a potential Ab target for developing novel HCC therapy. However, a previously developed anti-FGF19 Ab disrupted FGF19's normal regulatory function and caused severe bile-acid-related side-effects despite of having potent antitumor effects in preclinical models. Here, we developed novel human Abs (G1A8 and HS29) that specifically target the N-terminus of FGF19. Both Abs inhibited FGF19-induced HCC cell proliferation in vitro and significantly suppressed HCC tumor growth in mouse models. Importantly, no bile-acid-related side effects were observed in preclinical cynomolgus monkeys. Fundamentally, our study demonstrates that it is possible to target FGF19 for anti-HCC therapies without adversely affecting its normal bile acid regulatory function, and highlights the exciting promise of G1A8 or HS29 as potential therapy for HCC.
		+
		+	Novel Abs targeting the N-terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile-acid-related side-effects.,Liu H, Zheng S, Hou X, Liu X, Du K, Lv X, Li Y, Yang F, Li W, Sui J Cancer Sci. 2020 May;111(5):1750-1760. doi: 10.1111/cas.14353. Epub 2020 Mar 20. PMID:32061104<ref>PMID:32061104</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ktr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Fibroblast growth factor 3D structures\|Fibroblast growth factor 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hou X]]		[[Category: Hou X]]

OCA at 13:59, 8 July 2020

OCA — Wed, 08 Jul 2020 13:59:36 GMT

←Older revision		Revision as of 13:59, 8 July 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6ktr is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of fibroblast growth factor 19 in complex with Fab==
-		+	<StructureSection load='6ktr' size='340' side='right'caption='[[6ktr]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KTR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KTR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ktr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ktr OCA], [http://pdbe.org/6ktr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ktr RCSB], [http://www.ebi.ac.uk/pdbsum/6ktr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ktr ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hou X]]
		+	[[Category: Li W]]
		+	[[Category: Li Y]]
		+	[[Category: Liu H]]
		+	[[Category: Liu X]]
		+	[[Category: Lv X]]
		+	[[Category: Sui J]]
		+	[[Category: Zheng S]]

OCA at 02:28, 13 February 2020

OCA — Thu, 13 Feb 2020 02:28:00 GMT

←Older revision		Revision as of 02:28, 13 February 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ktr is ON HOLD	+	The entry 6ktr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ktr" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 06:46:12 GMT

Protected "6ktr" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:46, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6ktr is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Oct 2019 06:46:11 GMT

New page: '''Unreleased structure''' The entry 6ktr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ktr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

6ktr - Revision history

OCA at 10:43, 22 November 2023

OCA at 13:59, 8 July 2020

OCA at 02:28, 13 February 2020

OCA: Protected "6ktr" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6ktr is ON HOLD Authors: Description: Category: Unreleased Structures