6ku8 - Revision history

OCA at 10:44, 22 November 2023

OCA — Wed, 22 Nov 2023 10:44:01 GMT

←Older revision		Revision as of 10:44, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='6ku8' size='340' side='right'caption='[[6ku8]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='6ku8' size='340' side='right'caption='[[6ku8]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ku8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human_rhinovirus_c Human rhinovirus c~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KU8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6KU8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ku8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhinovirus_C Rhinovirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KU8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG7:4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC+ACID+ETHYL+ESTER'>AG7</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ku8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ku8 OCA], [~~http~~://pdbe.org/6ku8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ku8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ku8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ku8 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG7:4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC+ACID+ETHYL+ESTER'>AG7</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ku8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ku8 OCA], [https://pdbe.org/6ku8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ku8 RCSB], [https://www.ebi.ac.uk/pdbsum/6ku8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ku8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/E5D8F2_9ENTO E5D8F2_9ENTO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6ku8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6ku8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Human rhinovirus\|Human rhinovirus]]
		+	*[[Virus protease 3D structures\|Virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human rhinovirus c]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Yuan, S~~]]	+	[[Category: Rhinovirus C]]
-	[[Category: ~~Zhu, L~~]]	+	[[Category: Yuan S]]
-	[[Category: ~~Hrv]]~~	+	[[Category: Zhu L]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Rupintrivir~~]]	+

OCA at 10:02, 16 September 2020

OCA — Wed, 16 Sep 2020 10:02:58 GMT

←Older revision		Revision as of 10:02, 16 September 2020
Line 3:		Line 3:
	<StructureSection load='6ku8' size='340' side='right'caption='[[6ku8]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='6ku8' size='340' side='right'caption='[[6ku8]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ku8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KU8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6KU8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ku8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_rhinovirus_c Human rhinovirus c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KU8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KU8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG7:4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC+ACID+ETHYL+ESTER'>AG7</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG7:4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC+ACID+ETHYL+ESTER'>AG7</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ku8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ku8 OCA], [http://pdbe.org/6ku8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ku8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ku8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ku8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ku8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ku8 OCA], [http://pdbe.org/6ku8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ku8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ku8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ku8 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human rhinovirus c]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Yuan, S]]		[[Category: Yuan, S]]

OCA at 10:07, 27 March 2020

OCA — Fri, 27 Mar 2020 10:07:51 GMT

←Older revision		Revision as of 10:07, 27 March 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ku8 is ~~ON HOLD until Paper~~ Publication	+	==structure of HRV-C 3C protein with rupintrivir==
		+	<StructureSection load='6ku8' size='340' side='right'caption='[[6ku8]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ku8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KU8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG7:4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC+ACID+ETHYL+ESTER'>AG7</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ku8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ku8 OCA], [http://pdbe.org/6ku8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ku8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ku8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ku8 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human rhinoviruses (HRVs) are the predominant infectious agents for the common cold worldwide. The HRV-C species cause severe illnesses in children and are closely related to acute exacerbations of asthma. 3C protease, a highly conserved enzyme, cleaves the viral polyprotein during replication and assists the virus in escaping the host immune system. These key roles make 3C protease an important drug target. A few structures of 3Cs complexed with an irreversible inhibitor rupintrivir have been determined. These structures shed light on the determinants of drug specificity. Here we describe the structures of HRV-C15 3C in free and inhibitor-bound forms. The volume-decreased S1' subsite and half-closed S2 subsite, which were thought to be unique features of enterovirus A 3C proteases, appear in the HRV-C 3C protease. Rupintrivir assumes an "intermediate" conformation in the complex, which might open up additional avenues for the design of potent antiviral inhibitors. Analysis of the features of the three-dimensional structures and the amino acid sequences of 3C proteases suggest new applications for existing drugs.

-	~~Authors~~:	+	Structure of the HRV-C 3C-Rupintrivir Complex Provides New Insights for Inhibitor Design.,Yuan S, Fan K, Chen Z, Sun Y, Hou H, Zhu L Virol Sin. 2020 Feb 26. pii: 10.1007/s12250-020-00196-4. doi:, 10.1007/s12250-020-00196-4. PMID:32103448<ref>PMID:32103448</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6ku8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Yuan, S]]
		+	[[Category: Zhu, L]]
		+	[[Category: Hrv]]
		+	[[Category: Hydrolase]]
		+	[[Category: Protease]]
		+	[[Category: Rupintrivir]]

OCA: Protected "6ku8" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 06:47:22 GMT

Protected "6ku8" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:47, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6ku8 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 02 Oct 2019 06:47:20 GMT

New page: '''Unreleased structure''' The entry 6ku8 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ku8 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]