6kxg - Revision history

OCA at 10:46, 22 November 2023

OCA — Wed, 22 Nov 2023 10:46:11 GMT

←Older revision		Revision as of 10:46, 22 November 2023
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	<StructureSection load='6kxg' size='340' side='right'caption='[[6kxg]], [[Resolution\|resolution]] 2.81Å' scene=''>		<StructureSection load='6kxg' size='340' side='right'caption='[[6kxg]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kxg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kxg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KXG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxg OCA], [https://pdbe.org/6kxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kxg RCSB], [https://www.ebi.ac.uk/pdbsum/6kxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxg ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.805Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxg OCA], [https://pdbe.org/6kxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kxg RCSB], [https://www.ebi.ac.uk/pdbsum/6kxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6kxg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6kxg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Caspase 3D structures\|Caspase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Jin~~, T C~~]]	+	[[Category: Jin TC]]
-	[[Category: Liu~~, M Z.Y]]~~	+	[[Category: Liu MZY]]
-	~~[[Category: Card]]~~	+
-	~~[[Category: Caspase-11]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Inflammasome~~]]	+

OCA at 10:39, 31 March 2021

OCA — Wed, 31 Mar 2021 10:39:57 GMT

←Older revision		Revision as of 10:39, 31 March 2021
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	==Crystal structure of caspase-11-CARD==		==Crystal structure of caspase-11-CARD==
-	<StructureSection load='6kxg' size='340' side='right'caption='[[6kxg]]' scene=''>	+	<StructureSection load='6kxg' size='340' side='right'caption='[[6kxg]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6KXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kxg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KXG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6kxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxg OCA], [~~http~~://pdbe.org/6kxg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6kxg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6kxg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxg ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxg OCA], [https://pdbe.org/6kxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kxg RCSB], [https://www.ebi.ac.uk/pdbsum/6kxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxg ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Murine caspase-11 is the centerpiece of the non-canonical inflammasome pathway that can respond to intracellular LPS and induce pyroptosis. Caspase-11 contains two components, an N-terminal caspase recruitment domain (CARD) and a C-terminal catalytic domain. The aggregation of caspase-11 is thought to promote the auto-processing and activation of caspase-11. However, the activation mechanism of caspase-11 remains unclear. In this study, we purified the caspase-11 CARD fused to an MBP tag and found it tetramerizes in solution. Crystallographic analysis reveals an extensive hydrophobic interface formed by the H1-2 helix mediating homotypic CARD interactions. Importantly, mutations of the helix H1-2 hydrophobic residues abolished the tetramerization of MBP-tagged CARD in solution and failed to induce pyroptosis in cells. Our study provides the first evidence of the homotypic interaction mode for an inflammatory caspase by crystal model. This finding demonstrates that the tetramerization of the N-terminal CARD can promote releasing of the catalytic domain auto-inhibition, leading to the caspase-11 activation.
		+
		+	Crystal structure of caspase-11 CARD provides insights into caspase-11 activation.,Liu M, Zhou K, Xu Z, Ma H, Cao X, Yin X, Zeng W, Zahid A, Fu S, Ni K, Ye X, Zhou Y, Bai L, Zhou R, Jin T Cell Discov. 2020 Oct 13;6:70. doi: 10.1038/s41421-020-00201-w. eCollection 2020. PMID:33083005<ref>PMID:33083005</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6kxg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jin TC]]	+	[[Category: Lk3 transgenic mice]]
-	[[Category: Liu ~~MZY~~]]	+	[[Category: Jin, T C]]
		+	[[Category: Liu, M Z.Y]]
		+	[[Category: Card]]
		+	[[Category: Caspase-11]]
		+	[[Category: Immune system]]
		+	[[Category: Inflammasome]]

OCA at 09:44, 16 September 2020

OCA — Wed, 16 Sep 2020 09:44:52 GMT

←Older revision		Revision as of 09:44, 16 September 2020
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-	'''Unreleased structure'''

-	~~The entry 6kxg is ON HOLD until Sep~~ 11 ~~2021~~	+	==Crystal structure of caspase-11-CARD==
-		+	<StructureSection load='6kxg' size='340' side='right'caption='[[6kxg]]' scene=''>
-	~~Authors~~: ~~Liu~~, M.Z.Y., ~~Jin~~, T.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KXG FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of caspase~~-~~11-CARD~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxg OCA], [http://pdbe.org/6kxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kxg RCSB], [http://www.ebi.ac.uk/pdbsum/6kxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxg ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Liu, M.Z.Y~~]]	+	__TOC__
-	[[Category: ~~Jin, T.C~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Jin TC]]
		+	[[Category: Liu MZY]]

OCA at 04:48, 23 October 2019

OCA — Wed, 23 Oct 2019 04:48:22 GMT

←Older revision		Revision as of 04:48, 23 October 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6kxg is ON HOLD	+	The entry 6kxg is ON HOLD until Sep 11 2021

	Authors: Liu, M.Z.Y., Jin, T.C.		Authors: Liu, M.Z.Y., Jin, T.C.

OCA: Protected "6kxg" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 06:55:58 GMT

Protected "6kxg" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:55, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6kxg is ON HOLD Authors: Liu, M.Z.Y., Jin, T.C. Description: Crystal structure of caspase-11-CARD Category: Unreleased Structures [[Category: L...

OCA — Wed, 02 Oct 2019 06:55:56 GMT

New page: '''Unreleased structure''' The entry 6kxg is ON HOLD Authors: Liu, M.Z.Y., Jin, T.C. Description: Crystal structure of caspase-11-CARD Category: Unreleased Structures [[Category: L...

New page

'''Unreleased structure'''

The entry 6kxg is ON HOLD

Authors: Liu, M.Z.Y., Jin, T.C.

Description: Crystal structure of caspase-11-CARD
[[Category: Unreleased Structures]]
[[Category: Liu, M.Z.Y]]
[[Category: Jin, T.C]]