6kxw - Revision history

OCA at 10:46, 22 November 2023

OCA — Wed, 22 Nov 2023 10:46:28 GMT

←Older revision		Revision as of 10:46, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='6kxw' size='340' side='right'caption='[[6kxw]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='6kxw' size='340' side='right'caption='[[6kxw]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kxw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kxw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KXW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.7Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~AQP7, AQP7L, AQP9 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxw OCA], [https://pdbe.org/6kxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kxw RCSB], [https://www.ebi.ac.uk/pdbsum/6kxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxw OCA], [https://pdbe.org/6kxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kxw RCSB], [https://www.ebi.ac.uk/pdbsum/6kxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>	+	[https://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cao, Y]]	+	[[Category: Cao Y]]
-	[[Category: Yao, D]]	+	[[Category: Yao D]]
-	[[Category: Zhang, L]]	+	[[Category: Zhang L]]
-	[[Category: Zhang, Q]]	+	[[Category: Zhang Q]]
-	[[Category: Zhou, F]]	+	[[Category: Zhou F]]
-	[[Category: Zhou, L]]	+	[[Category: Zhou L]]
-	~~[[Category: Aquaporin]]~~	+
-	~~[[Category: Lipid metabolism]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transporter~~]]	+

OCA at 09:02, 8 September 2021

OCA — Wed, 08 Sep 2021 09:02:15 GMT

←Older revision		Revision as of 09:02, 8 September 2021
Line 3:		Line 3:
	<StructureSection load='6kxw' size='340' side='right'caption='[[6kxw]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='6kxw' size='340' side='right'caption='[[6kxw]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kxw]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6KXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kxw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KXW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AQP7, AQP7L, AQP9 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AQP7, AQP7L, AQP9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6kxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxw OCA], [~~http~~://pdbe.org/6kxw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6kxw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6kxw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxw OCA], [https://pdbe.org/6kxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kxw RCSB], [https://www.ebi.ac.uk/pdbsum/6kxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>	+	[[https://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>

	==See Also==		==See Also==

OCA at 12:40, 16 December 2020

OCA — Wed, 16 Dec 2020 12:40:43 GMT

←Older revision		Revision as of 12:40, 16 December 2020
Line 3:		Line 3:
	<StructureSection load='6kxw' size='340' side='right'caption='[[6kxw]], [[Resolution\|resolution]] 3.70Å' scene=''>		<StructureSection load='6kxw' size='340' side='right'caption='[[6kxw]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6kxw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6KXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6kxw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KXW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6kxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxw OCA], [http://pdbe.org/6kxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kxw RCSB], [http://www.ebi.ac.uk/pdbsum/6kxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxw ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AQP7, AQP7L, AQP9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6kxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxw OCA], [http://pdbe.org/6kxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kxw RCSB], [http://www.ebi.ac.uk/pdbsum/6kxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>		[[http://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>
		+
		+	==See Also==
		+	*[[Aquaporin 3D structures\|Aquaporin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cao, Y]]		[[Category: Cao, Y]]

OCA at 06:48, 27 November 2019

OCA — Wed, 27 Nov 2019 06:48:35 GMT

←Older revision		Revision as of 06:48, 27 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6kxw is ~~ON HOLD~~	+	==Crystal structure of human aquaporin AQP7 in bound to glycerol==
-		+	<StructureSection load='6kxw' size='340' side='right'caption='[[6kxw]], [[Resolution\|resolution]] 3.70Å' scene=''>
-	~~Authors~~: ~~Zhang, L~~., ~~Yao, D~~., ~~Zhou, F~~., ~~Zhang, Q~~., ~~Zhou, L~~., ~~Cao, Y~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6kxw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KXW FirstGlance]. <br>
-	~~Description~~: ~~A human solute~~ channel in ~~bound~~ to ~~substrate~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kxw OCA], [http://pdbe.org/6kxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kxw RCSB], [http://www.ebi.ac.uk/pdbsum/6kxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kxw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AQP7_HUMAN AQP7_HUMAN]] Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).[UniProtKB:O54794]<ref>PMID:11952783</ref> <ref>PMID:30420639</ref> <ref>PMID:30423801</ref> <ref>PMID:9405233</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cao, Y]]		[[Category: Cao, Y]]
		+	[[Category: Yao, D]]
	[[Category: Zhang, L]]		[[Category: Zhang, L]]
-	[[Category: ~~Yao~~, D]]	+	[[Category: Zhang, Q]]
		+	[[Category: Zhou, F]]
	[[Category: Zhou, L]]		[[Category: Zhou, L]]
-	[[Category: ~~Zhou, F~~]]	+	[[Category: Aquaporin]]
-	[[Category: ~~Zhang, Q~~]]	+	[[Category: Lipid metabolism]]
		+	[[Category: Membrane protein]]
		+	[[Category: Transporter]]

OCA: Protected "6kxw" [edit=sysop:move=sysop]

OCA — Wed, 02 Oct 2019 06:57:36 GMT

Protected "6kxw" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:57, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6kxw is ON HOLD Authors: Zhang, L., Yao, D., Zhou, F., Zhang, Q., Zhou, L., Cao, Y. Description: A human solute channel in bound to substrate [[Cat...

OCA — Wed, 02 Oct 2019 06:57:34 GMT

New page: '''Unreleased structure''' The entry 6kxw is ON HOLD Authors: Zhang, L., Yao, D., Zhou, F., Zhang, Q., Zhou, L., Cao, Y. Description: A human solute channel in bound to substrate [[Cat...

New page

'''Unreleased structure'''

The entry 6kxw is ON HOLD

Authors: Zhang, L., Yao, D., Zhou, F., Zhang, Q., Zhou, L., Cao, Y.

Description: A human solute channel in bound to substrate
[[Category: Unreleased Structures]]
[[Category: Cao, Y]]
[[Category: Zhang, L]]
[[Category: Yao, D]]
[[Category: Zhou, L]]
[[Category: Zhou, F]]
[[Category: Zhang, Q]]