6l31 - Revision history

OCA at 02:34, 11 April 2020

OCA — Sat, 11 Apr 2020 02:34:05 GMT

←Older revision		Revision as of 02:34, 11 April 2020
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	<SX load='6l31' size='340' side='right' viewer='molstar' caption='[[6l31]], [[Resolution\|resolution]] 4.18Å' scene=''>		<SX load='6l31' size='340' side='right' viewer='molstar' caption='[[6l31]], [[Resolution\|resolution]] 4.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6l31]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L31 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6L31 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6l31]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L31 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6L31 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6l31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l31 OCA], [http://pdbe.org/6l31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l31 RCSB], [http://www.ebi.ac.uk/pdbsum/6l31 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l31 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6l31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l31 OCA], [http://pdbe.org/6l31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l31 RCSB], [http://www.ebi.ac.uk/pdbsum/6l31 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l31 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 22:29, 6 March 2020

OCA — Fri, 06 Mar 2020 22:29:15 GMT

←Older revision		Revision as of 22:29, 6 March 2020
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	==L1 protein of human papillomavirus 6==		==L1 protein of human papillomavirus 6==
-	<~~StructureSection~~ load='6l31' size='340' side='right'caption='[[6l31]], [[Resolution\|resolution]] 4.18Å' scene=''>	+	<SX load='6l31' size='340' side='right' viewer='molstar' caption='[[6l31]], [[Resolution\|resolution]] 4.18Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6l31]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L31 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L31 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6l31]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L31 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L31 FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gu, Y]]		[[Category: Gu, Y]]

OCA at 09:05, 25 December 2019

OCA — Wed, 25 Dec 2019 09:05:52 GMT

←Older revision		Revision as of 09:05, 25 December 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6l31 is ~~ON HOLD~~	+	==L1 protein of human papillomavirus 6==
		+	<StructureSection load='6l31' size='340' side='right'caption='[[6l31]], [[Resolution\|resolution]] 4.18Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6l31]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L31 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L31 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l31 OCA], [http://pdbe.org/6l31 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l31 RCSB], [http://www.ebi.ac.uk/pdbsum/6l31 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l31 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0A140GKY2_9PAPI A0A140GKY2_9PAPI]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248][SAAS:SAAS00514925]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human papillomavirus type 6 (HPV6) is the major etiologic agent of genital warts and recurrent respiratory papillomatosis. Although the commercial HPV vaccines cover HPV6, the neutralization sites and mode for HPV6 are poorly understood. Here, we identify the HPV6 neutralization sites and discriminate the inhibition of virus attachment and entry by three potent neutralizing antibodies (nAbs), 5D3, 17D5, and 15F7. Mutagenesis assays showed that these nAbs predominantly target surface loops BC, DE, and FG of HPV6 L1. Cryo-EM structures of the HPV6 pseudovirus (PsV) and its immune complexes revealed three distinct binding modalities - full-occupation-bound to capsid, top-center-bound-, and top-rim-bound to pentamers - and illustrated a structural atlas for three classes of antibody-bound footprints that are located at center-distal ring, center, and center-proximal ring of pentamer surface for 5D3, 17D5, and 15F7, respectively. Two modes of neutralization were identified: mAb 5D3 and 17D5 block HPV PsV from attaching to the extracellular matrix (ECM) and the cell surface, whereas 15F7 allows PsV attachment but prohibits PsV from entering the cell. These findings highlight three neutralization sites of HPV6 L1 and outline two antibody-mediated neutralization mechanisms against HPV6, which will be relevant for HPV virology and antiviral inhibitor design. HighlightsMajor neutralization sites of HPV6 were mapped on the pseudovirus cryo-EM structuremAb 15F7 binds HPV6 capsid with a novel top-rim binding modality and confers a post-attachment neutralizationmAb 17D5 binds capsid in top-centre manner but unexpectedly prevents virus from attachment to cell surface.

-	~~Authors~~:	+	Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection.,Liu X, Chen J, Wang Z, Wang D, He M, Qian C, Song S, Chi X, Kong Z, Zheng Q, Wang Y, Yu H, Zhao Q, Zhang J, Li S, Gu Y, Xia N Emerg Microbes Infect. 2019;8(1):1721-1733. doi: 10.1080/22221751.2019.1694396. PMID:31769733<ref>PMID:31769733</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6l31" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Gu, Y]]
		+	[[Category: Li, S W]]
		+	[[Category: Liu, X L]]
		+	[[Category: Human papillomavirus]]
		+	[[Category: Major protein]]
		+	[[Category: Psv]]
		+	[[Category: Viral protein]]
		+	[[Category: Virus]]
		+	[[Category: Virus like particle]]

OCA: Protected "6l31" [edit=sysop:move=sysop]

OCA — Wed, 16 Oct 2019 04:19:35 GMT

Protected "6l31" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:19, 16 October 2019

OCA: New page: '''Unreleased structure''' The entry 6l31 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 Oct 2019 04:19:33 GMT

New page: '''Unreleased structure''' The entry 6l31 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6l31 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]