6l53 - Revision history

OCA at 10:45, 27 March 2024

OCA — Wed, 27 Mar 2024 10:45:26 GMT

←Older revision		Revision as of 10:45, 27 March 2024
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	==Structure of SMG1==		==Structure of SMG1==
-	<StructureSection load='6l53' size='340' side='right'caption='[[6l53]]' scene=''>	+	<StructureSection load='6l53' size='340' side='right'caption='[[6l53]], [[Resolution\|resolution]] 3.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L53 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6L53 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6l53]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L53 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6l53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l53 OCA], [~~http~~://pdbe.org/6l53 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6l53 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6l53 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6l53 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.63Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l53 OCA], [https://pdbe.org/6l53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l53 RCSB], [https://www.ebi.ac.uk/pdbsum/6l53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l53 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SMG1_HUMAN SMG1_HUMAN] Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.<ref>PMID:11331269</ref> <ref>PMID:11544179</ref> <ref>PMID:15175154</ref> <ref>PMID:16452507</ref>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Qi Y]]		[[Category: Qi Y]]
	[[Category: Xu Y]]		[[Category: Xu Y]]

OCA at 06:52, 15 April 2020

OCA — Wed, 15 Apr 2020 06:52:01 GMT

←Older revision		Revision as of 06:52, 15 April 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6l53 ~~is ON HOLD until Oct 22 2021~~	+	==Structure of SMG1==
-		+	<StructureSection load='6l53' size='340' side='right'caption='[[6l53]]' scene=''>
-	~~Authors~~: Xu, Y., Qi, Y.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L53 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6L53 FirstGlance]. <br>
-	~~Description: Structure of SMG1~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6l53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l53 OCA], [http://pdbe.org/6l53 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l53 RCSB], [http://www.ebi.ac.uk/pdbsum/6l53 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l53 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Qi, Y]]	+	__TOC__
-	[[Category: Xu, Y]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Qi Y]]
		+	[[Category: Xu Y]]

OCA at 05:25, 8 April 2020

OCA — Wed, 08 Apr 2020 05:25:05 GMT

←Older revision		Revision as of 05:25, 8 April 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6l53 is ON HOLD	+	The entry 6l53 is ON HOLD until Oct 22 2021

	Authors: Xu, Y., Qi, Y.		Authors: Xu, Y., Qi, Y.

OCA: Protected "6l53" [edit=sysop:move=sysop]

OCA — Wed, 30 Oct 2019 07:20:30 GMT

Protected "6l53" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:20, 30 October 2019

OCA: New page: '''Unreleased structure''' The entry 6l53 is ON HOLD Authors: Xu, Y., Qi, Y. Description: Structure of SMG1 Category: Unreleased Structures Category: Qi, Y Category: Xu, Y

OCA — Wed, 30 Oct 2019 07:20:29 GMT

New page: '''Unreleased structure''' The entry 6l53 is ON HOLD Authors: Xu, Y., Qi, Y. Description: Structure of SMG1 Category: Unreleased Structures Category: Qi, Y Category: Xu, Y

New page

'''Unreleased structure'''

The entry 6l53 is ON HOLD

Authors: Xu, Y., Qi, Y.

Description: Structure of SMG1
[[Category: Unreleased Structures]]
[[Category: Qi, Y]]
[[Category: Xu, Y]]