6l68 - Revision history

OCA at 10:52, 22 November 2023

OCA — Wed, 22 Nov 2023 10:52:07 GMT

←Older revision		Revision as of 10:52, 22 November 2023
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	<StructureSection load='6l68' size='340' side='right'caption='[[6l68]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='6l68' size='340' side='right'caption='[[6l68]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6l68]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L68 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6L68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6l68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L68 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALL:D-ALLOPYRANOSE'>ALL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.92Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l68 OCA], [~~http~~://pdbe.org/6l68 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6l68 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6l68 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6l68 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALL:D-ALLOPYRANOSE'>ALL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l68 OCA], [https://pdbe.org/6l68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l68 RCSB], [https://www.ebi.ac.uk/pdbsum/6l68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l68 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LEG10_HUMAN LEG10_HUMAN]] Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).<ref>PMID:17502455</ref>	+	[https://www.uniprot.org/uniprot/LEG10_HUMAN LEG10_HUMAN] Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).<ref>PMID:17502455</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6l68" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6l68" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kamitori, S]]	+	[[Category: Kamitori S]]
-	~~[[Category: Beta-sandwich structure]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 06:41, 4 March 2020

OCA — Wed, 04 Mar 2020 06:41:42 GMT

←Older revision		Revision as of 06:41, 4 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6l68 is ~~ON HOLD~~	+	==X-ray structure of human galectin-10 in complex with D-allose==
		+	<StructureSection load='6l68' size='340' side='right'caption='[[6l68]], [[Resolution\|resolution]] 1.92Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6l68]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L68 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALL:D-ALLOPYRANOSE'>ALL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l68 OCA], [http://pdbe.org/6l68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l68 RCSB], [http://www.ebi.ac.uk/pdbsum/6l68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l68 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEG10_HUMAN LEG10_HUMAN]] Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).<ref>PMID:17502455</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The galectins are a family of beta-galactoside-specific animal lectins, and have attracted much attention as novel regulators of the immune system. Galectin-10 is well-expressed in eosinophils, and spontaneously forms Charcot-Leyden crystals (CLCs), during prolonged eosinophilic inflammatory reactions, which are frequently observed in eosinophilic diseases. Although biochemical and structural characterizations of galectin-10 have been done, its biological role and molecular mechanism are still unclear, and few X-ray structures of galectin-10 in complex with monosaccharides/oligosaccharides have been reported. Here, X-ray structures of galectin-10 in complexes with seven monosaccharides are presented with biochemical analyses to detect interactions of galectin-10 with monosaccharides/oligosaccharides. Galectin-10 forms a homo-dimer in the face-to-face orientation, and the monosaccharides bind to the carbohydrate recognition site composed of amino acid residues from two galectin-10 molecules of dimers, suggesting that galectin-10 dimer likely captures the monosaccharides in solution and in vivo. d-Glucose, d-allose, d-arabinose, and D-N-acetylgalactosamine bind to the interfaces between galectin-10 dimers in crystals, and they affect the stability of molecular packing in crystals, leading to easy-dissolving of CLCs, and/or inhibiting the formation of CLCs. These monosaccharides may serve as effectors of G10 to form CLCs in vivo.

-	~~Authors: Kamitori~~, S.	+	Structures of human galectin-10/monosaccharide complexes demonstrate potential of monosaccharides as effectors in forming Charcot-Leyden crystals.,Itoh A, Nonaka Y, Nakakita SI, Yoshida H, Nishi N, Nakamura T, Kamitori S Biochem Biophys Res Commun. 2020 Feb 17. pii: S0006-291X(20)30303-X. doi:, 10.1016/j.bbrc.2020.02.037. PMID:32081418<ref>PMID:32081418</ref>

-	~~Description: X-ray structure~~ of ~~human galectin~~-~~10 in complex with D~~-~~allose~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6l68" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kamitori, S]]		[[Category: Kamitori, S]]
		+	[[Category: Beta-sandwich structure]]
		+	[[Category: Lectin]]
		+	[[Category: Sugar binding protein]]

OCA: Protected "6l68" [edit=sysop:move=sysop]

OCA — Wed, 06 Nov 2019 05:01:45 GMT

Protected "6l68" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:01, 6 November 2019

OCA: New page: '''Unreleased structure''' The entry 6l68 is ON HOLD Authors: Kamitori, S. Description: X-ray structure of human galectin-10 in complex with D-allose [[Category: Unreleased Structures]...

OCA — Wed, 06 Nov 2019 05:01:43 GMT

New page: '''Unreleased structure''' The entry 6l68 is ON HOLD Authors: Kamitori, S. Description: X-ray structure of human galectin-10 in complex with D-allose [[Category: Unreleased Structures]...

New page

'''Unreleased structure'''

The entry 6l68 is ON HOLD

Authors: Kamitori, S.

Description: X-ray structure of human galectin-10 in complex with D-allose
[[Category: Unreleased Structures]]
[[Category: Kamitori, S]]