6l6q - Revision history

OCA at 10:52, 22 November 2023

OCA — Wed, 22 Nov 2023 10:52:27 GMT

←Older revision		Revision as of 10:52, 22 November 2023
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	<StructureSection load='6l6q' size='340' side='right'caption='[[6l6q]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6l6q' size='340' side='right'caption='[[6l6q]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6l6q]] is a 4 chain structure with sequence from [~~http://en.wikipedia.org/wiki/ ] and [http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L6Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6L6Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6l6q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L6Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.601Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~NR4A2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6l6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l6q OCA], [~~http~~://pdbe.org/6l6q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6l6q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6l6q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6l6q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l6q OCA], [https://pdbe.org/6l6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l6q RCSB], [https://www.ebi.ac.uk/pdbsum/6l6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l6q ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NR4A2_HUMAN NR4A2_HUMAN] Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	[[Category: Jiang, L]]	+	[[Category: Jiang L]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Nr4a2]]~~	+
-	~~[[Category: Nuclear receptor~~]]	+

OCA at 08:45, 27 November 2019

OCA — Wed, 27 Nov 2019 08:45:22 GMT

←Older revision		Revision as of 08:45, 27 November 2019
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	<StructureSection load='6l6q' size='340' side='right'caption='[[6l6q]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6l6q' size='340' side='right'caption='[[6l6q]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6l6q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L6Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6l6q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L6Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NR4A2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l6q OCA], [http://pdbe.org/6l6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l6q RCSB], [http://www.ebi.ac.uk/pdbsum/6l6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l6q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l6q OCA], [http://pdbe.org/6l6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l6q RCSB], [http://www.ebi.ac.uk/pdbsum/6l6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l6q ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proteins of nuclear receptor subfamily 4 group A (NR4A), including NR4A1/NGFI-B, NR4A2/Nurr1, and NR4A3/NOR-1, are nuclear transcription factors that play important roles in metabolism, apoptosis, and proliferation. NR4A proteins recognize DNA response elements as monomers or dimers to regulate the transcription of a variety of genes involved in multiple biological processes. In this study, we determined two crystal structures of the NR4A2 DNA-binding domain (NR4A2-DBD) bound to two Nur-responsive elements (NurREs), namely, an inverted repeat and an everted repeat at 2.6-2.8 A resolutions. The structures revealed that two NR4A2-DBD molecules bind independently to the everted repeat, whereas two other NR4A2-DBD molecules form a novel dimer interface on the inverted repeat. Moreover, substitution of the interfacial residue Valine 298 to lysine, as well as mutation of DNA bases involved in the interactions, abolished the dimerization. Overall, our structural, biochemical, and bioinformatics analyses provide a molecular basis for the binding of the NR4A2 protein dimers to NurREs and advance our understanding of the dimerization specificity of nuclear receptors.
		+
		+	Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements.,Jiang L, Dai S, Li J, Liang X, Qu L, Chen X, Guo M, Chen Z, Chen L, Wei H, Chen Y J Biol Chem. 2019 Nov 13. pii: RA119.010730. doi: 10.1074/jbc.RA119.010730. PMID:31723028<ref>PMID:31723028</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6l6q" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]

OCA at 15:23, 20 November 2019

OCA — Wed, 20 Nov 2019 15:23:54 GMT

←Older revision		Revision as of 15:23, 20 November 2019
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-	'''Unreleased structure'''

-	~~The entry 6l6q is ON HOLD until Paper Publication~~	+	==Structural basis of NR4A2 homodimers binding to selective Nur-responsive elements==
-		+	<StructureSection load='6l6q' size='340' side='right'caption='[[6l6q]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors: Jiang, L., Chen, Y.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6l6q]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L6Q FirstGlance]. <br>
-	~~Description:~~ Structural basis of NR4A2 homodimers binding to selective Nur-responsive elements	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l6q OCA], [http://pdbe.org/6l6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l6q RCSB], [http://www.ebi.ac.uk/pdbsum/6l6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l6q ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Jiang, L]]		[[Category: Jiang, L]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Nr4a2]]
		+	[[Category: Nuclear receptor]]

OCA at 09:14, 13 November 2019

OCA — Wed, 13 Nov 2019 09:14:43 GMT

←Older revision		Revision as of 09:14, 13 November 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6l6q is ON HOLD	+	The entry 6l6q is ON HOLD until Paper Publication

	Authors: Jiang, L., Chen, Y.		Authors: Jiang, L., Chen, Y.

OCA: Protected "6l6q" [edit=sysop:move=sysop]

OCA — Wed, 06 Nov 2019 05:03:01 GMT

Protected "6l6q" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:03, 6 November 2019

OCA: New page: '''Unreleased structure''' The entry 6l6q is ON HOLD Authors: Jiang, L., Chen, Y. Description: Structural basis of NR4A2 homodimers binding to selective Nur-responsive elements [[Categ...

OCA — Wed, 06 Nov 2019 05:02:59 GMT

New page: '''Unreleased structure''' The entry 6l6q is ON HOLD Authors: Jiang, L., Chen, Y. Description: Structural basis of NR4A2 homodimers binding to selective Nur-responsive elements [[Categ...

New page

'''Unreleased structure'''

The entry 6l6q is ON HOLD

Authors: Jiang, L., Chen, Y.

Description: Structural basis of NR4A2 homodimers binding to selective Nur-responsive elements
[[Category: Unreleased Structures]]
[[Category: Chen, Y]]
[[Category: Jiang, L]]