6l7y - Revision history

OCA at 10:52, 22 November 2023

OCA — Wed, 22 Nov 2023 10:52:52 GMT

←Older revision		Revision as of 10:52, 22 November 2023
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	<StructureSection load='6l7y' size='340' side='right'caption='[[6l7y]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='6l7y' size='340' side='right'caption='[[6l7y]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6l7y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trycc Trycc~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L7Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6l7y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L7Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JJY:3,4,6,7-tetrahydroacridine-1,8(2H,5H)-dione'>JJY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tc00.1047053508479.390 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JJY:3,4,6,7-tetrahydroacridine-1,8(2H,5H)-dione'>JJY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l7y OCA], [https://pdbe.org/6l7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l7y RCSB], [https://www.ebi.ac.uk/pdbsum/6l7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l7y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l7y OCA], [https://pdbe.org/6l7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l7y RCSB], [https://www.ebi.ac.uk/pdbsum/6l7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l7y ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q4E2I1_TRYCC Q4E2I1_TRYCC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Trycc~~]]	+	[[Category: Trypanosoma cruzi strain CL Brener]]
-	[[Category: Ho, K]]	+	[[Category: Ho K]]
-	[[Category: Kuwabara, N]]	+	[[Category: Kuwabara N]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mrna capping]]~~	+
-	~~[[Category: Rna triphosphatase~~]]	+

OCA at 15:16, 8 June 2021

OCA — Tue, 08 Jun 2021 15:16:08 GMT

←Older revision		Revision as of 15:16, 8 June 2021
Line 3:		Line 3:
	<StructureSection load='6l7y' size='340' side='right'caption='[[6l7y]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='6l7y' size='340' side='right'caption='[[6l7y]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6l7y]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L7Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6L7Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6l7y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L7Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JJY:3,4,6,7-tetrahydroacridine-1,8(2H,5H)-dione'>JJY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JJY:3,4,6,7-tetrahydroacridine-1,8(2H,5H)-dione'>JJY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tc00.1047053508479.390 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tc00.1047053508479.390 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6l7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l7y OCA], [~~http~~://pdbe.org/6l7y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6l7y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6l7y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6l7y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l7y OCA], [https://pdbe.org/6l7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l7y RCSB], [https://www.ebi.ac.uk/pdbsum/6l7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l7y ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:52, 20 July 2020

OCA — Mon, 20 Jul 2020 08:52:24 GMT

←Older revision		Revision as of 08:52, 20 July 2020
Line 1:		Line 1:

-	==~~n/a~~==	+	==Crystal structure of Cet1 from Trypanosoma cruzi in complex with #466 ligand.==
-	<StructureSection load='6l7y' size='340' side='right'caption='[[6l7y]]' scene=''>	+	<StructureSection load='6l7y' size='340' side='right'caption='[[6l7y]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L7Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6L7Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6l7y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L7Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6L7Y FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6l7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l7y OCA], [http://pdbe.org/6l7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l7y RCSB], [http://www.ebi.ac.uk/pdbsum/6l7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l7y ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JJY:3,4,6,7-tetrahydroacridine-1,8(2H,5H)-dione'>JJY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tc00.1047053508479.390 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6l7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l7y OCA], [http://pdbe.org/6l7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l7y RCSB], [http://www.ebi.ac.uk/pdbsum/6l7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l7y ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RNA triphosphatase catalyzes the first step in mRNA cap formation, hydrolysis of the terminal phosphate from the nascent mRNA transcript. The RNA triphosphatase from the protozoan parasite Trypanosoma cruzi, TcCet1, belongs to the family of triphosphate tunnel metalloenzymes (TTMs). TcCet1 is a promising antiprotozoal drug target because the mechanism and structure of the protozoan RNA triphosphatases are completely different from those of the RNA triphosphatases found in mammalian and arthropod hosts. Here, we report several crystal structures of the catalytically active form of TcCet1 complexed with a divalent cation and an inorganic tripolyphosphate in the active-site tunnel at 2.20-2.51 A resolutions. The structures revealed that the overall structure, the architecture of the tunnel, and the arrangement of the metal-binding site in TcCet1 are similar to those in other TTM proteins. On the basis of the position of three sulfate ions that cocrystallized on the positively charged surface of the protein and results obtained from mutational analysis, we identified an RNA-binding site in TcCet1. We conclude that the 5'-end of the triphosphate RNA substrate enters the active-site tunnel directionally. The structural information reported here provides valuable insight into designing inhibitors that could specifically block the entry of the triphosphate RNA substrate into the TTM-type RNA triphosphatases of T. cruzi and related pathogens.
		+
		+	Crystal structures of the RNA triphosphatase from Trypanosoma cruzi provide insights into how it recognizes the 5'-end of the RNA substrate.,Takagi Y, Kuwabara N, Dang TT, Furukawa K, Ho CK J Biol Chem. 2020 Jul 3;295(27):9076-9086. doi: 10.1074/jbc.RA119.011811. Epub, 2020 May 7. PMID:32381506<ref>PMID:32381506</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6l7y" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: N/a]]	+	[[Category: Trycc]]
		+	[[Category: Ho, K]]
		+	[[Category: Kuwabara, N]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mrna capping]]
		+	[[Category: Rna triphosphatase]]

OCA at 06:26, 3 June 2020

OCA — Wed, 03 Jun 2020 06:26:46 GMT

←Older revision		Revision as of 06:26, 3 June 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6l7y ~~is ON HOLD until Paper Publication~~	+	==n/a==
-		+	<StructureSection load='6l7y' size='340' side='right'caption='[[6l7y]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L7Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6L7Y FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6l7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l7y OCA], [http://pdbe.org/6l7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l7y RCSB], [http://www.ebi.ac.uk/pdbsum/6l7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l7y ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: N/a]]

OCA at 13:24, 20 November 2019

OCA — Wed, 20 Nov 2019 13:24:14 GMT

←Older revision		Revision as of 13:24, 20 November 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6l7y is ON HOLD	+	The entry 6l7y is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6l7y" [edit=sysop:move=sysop]

OCA — Wed, 13 Nov 2019 09:16:10 GMT

Protected "6l7y" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:16, 13 November 2019

OCA: New page: '''Unreleased structure''' The entry 6l7y is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Nov 2019 09:16:09 GMT

New page: '''Unreleased structure''' The entry 6l7y is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6l7y is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]