6lah - Revision history

OCA at 10:54, 22 November 2023

OCA — Wed, 22 Nov 2023 10:54:27 GMT

←Older revision		Revision as of 10:54, 22 November 2023
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	<StructureSection load='6lah' size='340' side='right'caption='[[6lah]], [[Resolution\|resolution]] 1.87Å' scene=''>		<StructureSection load='6lah' size='340' side='right'caption='[[6lah]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6lah]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Macmu Macmu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LAH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6LAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lah]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EKG:(2R)-2,3-dihydroxypropyl+hexadecanoate'>EKG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.87Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mamu-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EKG:(2R)-2,3-dihydroxypropyl+hexadecanoate'>EKG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lah OCA], [~~http~~://pdbe.org/6lah PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6lah RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6lah PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6lah ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lah OCA], [https://pdbe.org/6lah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lah RCSB], [https://www.ebi.ac.uk/pdbsum/6lah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lah ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~B2MG_MACMU B2MG_MACMU~~]~~] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).~~	+	[https://www.uniprot.org/uniprot/A0A1E1GJG5_MACMU A0A1E1GJG5_MACMU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6lah" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6lah" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
		+	*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Macmu~~]]	+	[[Category: Macaca mulatta]]
-	[[Category: Morita, D]]	+	[[Category: Morita D]]
-	[[Category: Shima, Y]]	+	[[Category: Shima Y]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Lysophospholipid]]~~	+
-	~~[[Category: Mhc class i protein~~]]	+

OCA at 07:14, 27 May 2020

OCA — Wed, 27 May 2020 07:14:58 GMT

←Older revision		Revision as of 07:14, 27 May 2020
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	==Crystal structure of rhesus macaque MHC class I molecule Mamu-B*098 complexed with lysophosphatidylcholine==		==Crystal structure of rhesus macaque MHC class I molecule Mamu-B*098 complexed with lysophosphatidylcholine==
-	<StructureSection load='6lah' size='340' side='right'caption='[[6lah]]' scene=''>	+	<StructureSection load='6lah' size='340' side='right'caption='[[6lah]], [[Resolution\|resolution]] 1.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LAH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lah]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LAH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LAH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lah OCA], [http://pdbe.org/6lah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lah RCSB], [http://www.ebi.ac.uk/pdbsum/6lah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lah ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EKG:(2R)-2,3-dihydroxypropyl+hexadecanoate'>EKG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mamu-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 MACMU])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lah OCA], [http://pdbe.org/6lah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lah RCSB], [http://www.ebi.ac.uk/pdbsum/6lah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lah ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/B2MG_MACMU B2MG_MACMU]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Newly synthesized major histocompatibility complex (MHC) class I proteins are stabilized in the endoplasmic reticulum (ER) by binding 8- to 10-mer-long self-peptide antigens that are provided by transporter associated with antigen processing (TAP). These MHC class I:peptide complexes then exit the ER and reach the plasma membrane, serving to sustain the steady state MHC class I expression on the cell surface. A novel subset of MHC class I molecules that preferentially bind lipid-containing ligands rather than conventional peptides was recently identified. The primate classical MHC class I allomorphs, Mamu-B098 and Mamu-B05104, are capable of binding the N-myristoylated 5-mer (C14-Gly-Gly-Ala-Ile-Ser) or 4-mer (C14-Gly-Gly-Ala-Ile) lipopeptides derived from the N-myristoylated SIV Nef protein, respectively, and of activating lipopeptide antigen-specific cytotoxic T lymphocytes. We herein demonstrate that Mamu-B098 samples lysophosphatidylethanolamine and lysophosphatidylcholine containing up to a C20 fatty acid in the ER. The X-ray crystal structures of Mamu-B098 and Mamu-B*05104 complexed with lysophospholipids at high resolution revealed that the B and D pockets in the antigen-binding grooves of these MHC class I molecules accommodate these lipids through a mono-acyl glycerol moiety. Consistent with the capacity to bind cellular lipid ligands, these two MHC class I molecules did not require TAP function for cell-surface expression. Collectively, these results indicate that peptide- and lipopeptide-presenting MHC class I subsets use distinct sources of endogenous ligands.
		+
		+	Crystal structures of lysophospholipid-bound MHC class I molecules.,Shima Y, Morita D, Mizutani T, Mori N, Mikami B, Sugita M J Biol Chem. 2020 Apr 8. pii: RA119.011932. doi: 10.1074/jbc.RA119.011932. PMID:32269076<ref>PMID:32269076</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6lah" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Morita D]]	+	[[Category: Macmu]]
-	[[Category: Shima Y]]	+	[[Category: Morita, D]]
		+	[[Category: Shima, Y]]
		+	[[Category: Complex]]
		+	[[Category: Immune system]]
		+	[[Category: Lysophospholipid]]
		+	[[Category: Mhc class i protein]]

OCA at 05:40, 22 April 2020

OCA — Wed, 22 Apr 2020 05:40:08 GMT

←Older revision		Revision as of 05:40, 22 April 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6lah ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of rhesus macaque MHC class I molecule Mamu-B*098 complexed with lysophosphatidylcholine==
-		+	<StructureSection load='6lah' size='340' side='right'caption='[[6lah]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LAH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LAH FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lah OCA], [http://pdbe.org/6lah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lah RCSB], [http://www.ebi.ac.uk/pdbsum/6lah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lah ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Morita D]]
		+	[[Category: Shima Y]]

OCA at 05:04, 27 November 2019

OCA — Wed, 27 Nov 2019 05:04:12 GMT

←Older revision		Revision as of 05:04, 27 November 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6lah is ON HOLD	+	The entry 6lah is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6lah" [edit=sysop:move=sysop]

OCA — Wed, 20 Nov 2019 13:28:36 GMT

Protected "6lah" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:28, 20 November 2019

OCA: New page: '''Unreleased structure''' The entry 6lah is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Nov 2019 13:28:34 GMT

New page: '''Unreleased structure''' The entry 6lah is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6lah is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]