6lgj - Revision history

OCA at 10:59, 22 November 2023

OCA — Wed, 22 Nov 2023 10:59:54 GMT

←Older revision		Revision as of 10:59, 22 November 2023
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	==Crystal structure of an oxido-reductase==		==Crystal structure of an oxido-reductase==
-	<StructureSection load='6lgj' size='340' side='right'caption='[[6lgj]]' scene=''>	+	<StructureSection load='6lgj' size='340' side='right'caption='[[6lgj]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LGJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6LGJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lgj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LGJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6lgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lgj OCA], [~~http~~://pdbe.org/6lgj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6lgj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6lgj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6lgj ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lgj OCA], [https://pdbe.org/6lgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lgj RCSB], [https://www.ebi.ac.uk/pdbsum/6lgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lgj ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G3P_MOUSE G3P_MOUSE] Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:19903941). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:19903941). Modulates the organization and assembly of the cytoskeleton (By similarity). Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity).[UniProtKB:P04797][UniProtKB:P10096]<ref>PMID:19903941</ref> <ref>PMID:23071094</ref>
		+
		+	==See Also==
		+	*[[Glyceraldehyde-3-phosphate dehydrogenase 3D structures\|Glyceraldehyde-3-phosphate dehydrogenase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
	[[Category: Lei J]]		[[Category: Lei J]]
	[[Category: Yang Y]]		[[Category: Yang Y]]
	[[Category: Yin L]]		[[Category: Yin L]]

OCA at 06:34, 9 December 2020

OCA — Wed, 09 Dec 2020 06:34:38 GMT

←Older revision		Revision as of 06:34, 9 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6lgj ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of an oxido-reductase==
-		+	<StructureSection load='6lgj' size='340' side='right'caption='[[6lgj]]' scene=''>
-	~~Authors~~: ~~Yang~~, Y., ~~Lei~~, J., ~~Yin~~, L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LGJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LGJ FirstGlance]. <br>
-	~~Description: Crystal structure of an oxido-reductase~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lgj OCA], [http://pdbe.org/6lgj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lgj RCSB], [http://www.ebi.ac.uk/pdbsum/6lgj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lgj ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Yang, Y~~]]	+	__TOC__
-	[[Category: ~~Yin, L~~]]	+	</StructureSection>
-	[[Category: ~~Lei, J~~]]	+	[[Category: Large Structures]]
		+	[[Category: Lei J]]
		+	[[Category: Yang Y]]
		+	[[Category: Yin L]]

OCA at 03:45, 5 August 2020

OCA — Wed, 05 Aug 2020 03:45:14 GMT

←Older revision		Revision as of 03:45, 5 August 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6lgj is ON HOLD	+	The entry 6lgj is ON HOLD until Paper Publication

	Authors: Yang, Y., Lei, J., Yin, L.		Authors: Yang, Y., Lei, J., Yin, L.
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	Description: Crystal structure of an oxido-reductase		Description: Crystal structure of an oxido-reductase
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Yin, L]]
	[[Category: Yang, Y]]		[[Category: Yang, Y]]
		+	[[Category: Yin, L]]
	[[Category: Lei, J]]		[[Category: Lei, J]]

OCA: Protected "6lgj" [edit=sysop:move=sysop]

OCA — Wed, 11 Dec 2019 13:28:50 GMT

Protected "6lgj" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:28, 11 December 2019

OCA: New page: '''Unreleased structure''' The entry 6lgj is ON HOLD Authors: Yang, Y., Lei, J., Yin, L. Description: Crystal structure of an oxido-reductase Category: Unreleased Structures [[Cate...

OCA — Wed, 11 Dec 2019 13:28:48 GMT

New page: '''Unreleased structure''' The entry 6lgj is ON HOLD Authors: Yang, Y., Lei, J., Yin, L. Description: Crystal structure of an oxido-reductase Category: Unreleased Structures [[Cate...

New page

'''Unreleased structure'''

The entry 6lgj is ON HOLD

Authors: Yang, Y., Lei, J., Yin, L.

Description: Crystal structure of an oxido-reductase
[[Category: Unreleased Structures]]
[[Category: Yin, L]]
[[Category: Yang, Y]]
[[Category: Lei, J]]