6lhz - Revision history

OCA at 11:00, 22 November 2023

OCA — Wed, 22 Nov 2023 11:00:39 GMT

←Older revision		Revision as of 11:00, 22 November 2023
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	<StructureSection load='6lhz' size='340' side='right'caption='[[6lhz]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='6lhz' size='340' side='right'caption='[[6lhz]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6lhz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bommx Bommx~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LHZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6LHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lhz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombina_maxima Bombina maxima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LHZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6lhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lhz OCA], [~~http~~://pdbe.org/6lhz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6lhz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6lhz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6lhz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.52Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lhz OCA], [https://pdbe.org/6lhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lhz RCSB], [https://www.ebi.ac.uk/pdbsum/6lhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lhz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bommx~~]]	+	[[Category: Bombina maxima]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bian~~, X L~~]]	+	[[Category: Bian XL]]
-	[[Category: Li, X]]	+	[[Category: Li X]]
-	[[Category: Teng~~, M Q~~]]	+	[[Category: Teng MQ]]
-	[[Category: Wang~~, Q Q~~]]	+	[[Category: Wang QQ]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Aerolysin]]~~	+
-	~~[[Category: Amphibian]]~~	+
-	~~[[Category: Pore-forming]]~~	+
-	~~[[Category: Secretion]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 10:33, 17 June 2020

OCA — Wed, 17 Jun 2020 10:33:46 GMT

←Older revision		Revision as of 10:33, 17 June 2020
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	==Structure of aerolysin-like protein (Bombina maxima)==		==Structure of aerolysin-like protein (Bombina maxima)==
-	<StructureSection load='6lhz' size='340' side='right'caption='[[6lhz]]' scene=''>	+	<StructureSection load='6lhz' size='340' side='right'caption='[[6lhz]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LHZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lhz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bommx Bommx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LHZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LHZ FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lhz OCA], [http://pdbe.org/6lhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lhz RCSB], [http://www.ebi.ac.uk/pdbsum/6lhz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lhz ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lhz OCA], [http://pdbe.org/6lhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lhz RCSB], [http://www.ebi.ac.uk/pdbsum/6lhz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lhz ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Endolysosomes are key players in cell physiology, including molecular exchange, immunity, and environmental adaptation. They are the molecular target of some pore-forming aerolysin-like proteins (ALPs) that are widely distributed in animals and plants and are functionally related to bacterial toxin aerolysins. betagamma-CAT is a complex of an ALP (BmALP1) and a trefoil factor (BmTFF3) in the firebelly toad (Bombina maxima). It is the first example for a secreted endogenous pore-forming protein that modulates the biochemical properties of endolysosomes by inducing pore formation in these intracellular vesicles. Here, using a large array of biochemical and cell biology methods, we report the identification of BmALP3, a paralog of BmALP1 that lacks membrane pore- forming capacity. We noted that both BmALP3 and BmALP1 contain a conserved cysteine in their C-terminal regions. BmALP3 was readily oxidized to a disulfide bond-linked homodimer, and this homodimer then oxidized BmALP1 via disulfide bond exchange, resulting in the dissociation of betagamma-CAT subunits and elimination of its biological activity. Consistent with its behavior in vitro, BmALP3 sensed environmental oxygen tension in vivo, leading to modulation of betagamma-CAT activity. Interestingly, we found that this C-terminal cysteine site is well conserved in numerous vertebrate ALPs. These findings uncover the existence of a regulatory ALP (BmALP3) that modulates the activity on an active ALP (BmALP1) in a redox-dependent manner, a property that differs from those of bacterial toxin aerolysins.
		+
		+	A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions.,Wang Q, Bian X, Zeng L, Pan F, Liu L, Liang J, Wang L, Zhou K, Lee W, Xiang Y, Li S, Teng M, Li X, Guo X, Zhang Y J Biol Chem. 2020 Jun 4. pii: RA120.013556. doi: 10.1074/jbc.RA120.013556. PMID:32499370<ref>PMID:32499370</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6lhz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bommx]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bian XL]]	+	[[Category: Bian, X L]]
-	[[Category: Li X]]	+	[[Category: Li, X]]
-	[[Category: Teng MQ]]	+	[[Category: Teng, M Q]]
-	[[Category: Wang QQ]]	+	[[Category: Wang, Q Q]]
-	[[Category: Zhang Y]]	+	[[Category: Zhang, Y]]
		+	[[Category: Aerolysin]]
		+	[[Category: Amphibian]]
		+	[[Category: Pore-forming]]
		+	[[Category: Secretion]]
		+	[[Category: Toxin]]

OCA at 06:23, 10 June 2020

OCA — Wed, 10 Jun 2020 06:23:10 GMT

←Older revision		Revision as of 06:23, 10 June 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6lhz is ~~ON HOLD~~	+	==Structure of aerolysin-like protein (Bombina maxima)==
-		+	<StructureSection load='6lhz' size='340' side='right'caption='[[6lhz]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LHZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LHZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lhz OCA], [http://pdbe.org/6lhz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lhz RCSB], [http://www.ebi.ac.uk/pdbsum/6lhz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lhz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bian XL]]
		+	[[Category: Li X]]
		+	[[Category: Teng MQ]]
		+	[[Category: Wang QQ]]
		+	[[Category: Zhang Y]]

OCA: Protected "6lhz" [edit=sysop:move=sysop]

OCA — Wed, 18 Dec 2019 05:42:20 GMT

Protected "6lhz" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 18 December 2019

OCA: New page: '''Unreleased structure''' The entry 6lhz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Dec 2019 05:42:18 GMT

New page: '''Unreleased structure''' The entry 6lhz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6lhz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]