6lnm - Revision history

OCA at 11:04, 22 November 2023

OCA — Wed, 22 Nov 2023 11:04:05 GMT

←Older revision		Revision as of 11:04, 22 November 2023
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	<StructureSection load='6lnm' size='340' side='right'caption='[[6lnm]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6lnm' size='340' side='right'caption='[[6lnm]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6lnm]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LNM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6LNM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lnm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LNM FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Cask ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=10116 Buffalo rat]), Apba1, Mint1, X11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non~~-~~specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase]~~, ~~with EC number~~ [~~http://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~2.~~7.11.1 2.7.11.1] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lnm OCA], [https://pdbe.org/6lnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lnm RCSB], [https://www.ebi.ac.uk/pdbsum/6lnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lnm ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6lnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lnm OCA], [~~http~~://pdbe.org/6lnm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6lnm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6lnm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6lnm ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CSKP_RAT CSKP_RAT]] Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.<ref>PMID:10749215</ref> [[http://www.uniprot.org/uniprot/APBA1_MOUSE APBA1_MOUSE]] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity).	+	[https://www.uniprot.org/uniprot/CSKP_RAT CSKP_RAT] Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.<ref>PMID:10749215</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Non-specific serine/threonine protein kinase~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Cai, Q]]	+	[[Category: Cai Q]]
-	[[Category: Zhang, M]]	+	[[Category: Zhang M]]
-	~~[[Category: Calmodulin-dependent protein kinase]]~~	+
-	~~[[Category: Camk]]~~	+
-	~~[[Category: Cask]]~~	+
-	~~[[Category: Lin-2]]~~	+
-	~~[[Category: Maguk]]~~	+
-	~~[[Category: Mint1]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:31, 21 October 2020

OCA — Wed, 21 Oct 2020 08:31:12 GMT

←Older revision		Revision as of 08:31, 21 October 2020
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	<StructureSection load='6lnm' size='340' side='right'caption='[[6lnm]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6lnm' size='340' side='right'caption='[[6lnm]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6lnm]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LNM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LNM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lnm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LNM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LNM FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cask ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Apba1, Mint1, X11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lnm OCA], [http://pdbe.org/6lnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lnm RCSB], [http://www.ebi.ac.uk/pdbsum/6lnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lnm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lnm OCA], [http://pdbe.org/6lnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lnm RCSB], [http://www.ebi.ac.uk/pdbsum/6lnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lnm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CSKP_RAT CSKP_RAT]] Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.<ref>PMID:10749215</ref> [[http://www.uniprot.org/uniprot/APBA1_MOUSE APBA1_MOUSE]] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity).		[[http://www.uniprot.org/uniprot/CSKP_RAT CSKP_RAT]] Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.<ref>PMID:10749215</ref> [[http://www.uniprot.org/uniprot/APBA1_MOUSE APBA1_MOUSE]] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CASK forms an evolutionarily conserved tripartite complex with Mint1 and Veli critical for neuronal synaptic transmission and cell polarity. The CASK CaM kinase (CaMK) domain, in addition to interacting with Mint1, can also bind to many different target proteins, although the mechanism governing CASK-CaMK/target interaction selectivity is unclear. Here, we demonstrate that an extended sequence in the N-terminal unstructured region of Mint1 binds to CASK-CaMK with a dissociation constant of approximately 7.5 nM. The high-resolution crystal structure of CASK-CaMK in complex with this Mint1 fragment reveals that the C-lobe of CASK-CaMK binds to a short sequence common to known CaMK targets and the N-lobe of CaMK engages an alpha helix that is unique to Mint1. Biochemical experiments together with structural analysis reveal that the CASK and Mint1 interaction is not regulated by Ca(2+)/CaM. The CASK/Mint1 complex structure provides mechanistic explanations for several CASK mutations identified in patients with brain disorders and cancers.
		+
		+	Structural Basis for the High-Affinity Interaction between CASK and Mint1.,Wu X, Cai Q, Chen Y, Zhu S, Mi J, Wang J, Zhang M Structure. 2020 Jun 2;28(6):664-673.e3. doi: 10.1016/j.str.2020.04.001. Epub 2020, Apr 28. PMID:32348748<ref>PMID:32348748</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6lnm" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Cai, Q]]		[[Category: Cai, Q]]

OCA at 06:49, 8 April 2020

OCA — Wed, 08 Apr 2020 06:49:02 GMT

←Older revision		Revision as of 06:49, 8 April 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6lnm is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of CASK-CaMK in complex with Mint1-CID==
-		+	<StructureSection load='6lnm' size='340' side='right'caption='[[6lnm]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6lnm]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LNM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LNM FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lnm OCA], [http://pdbe.org/6lnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lnm RCSB], [http://www.ebi.ac.uk/pdbsum/6lnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lnm ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CSKP_RAT CSKP_RAT]] Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.<ref>PMID:10749215</ref> [[http://www.uniprot.org/uniprot/APBA1_MOUSE APBA1_MOUSE]] Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity).
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Cai, Q]]
		+	[[Category: Zhang, M]]
		+	[[Category: Calmodulin-dependent protein kinase]]
		+	[[Category: Camk]]
		+	[[Category: Cask]]
		+	[[Category: Lin-2]]
		+	[[Category: Maguk]]
		+	[[Category: Mint1]]
		+	[[Category: Transferase]]

OCA at 13:31, 22 January 2020

OCA — Wed, 22 Jan 2020 13:31:55 GMT

←Older revision		Revision as of 13:31, 22 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6lnm is ON HOLD	+	The entry 6lnm is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6lnm" [edit=sysop:move=sysop]

OCA — Wed, 08 Jan 2020 05:58:15 GMT

Protected "6lnm" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:58, 8 January 2020

OCA: New page: '''Unreleased structure''' The entry 6lnm is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Jan 2020 05:58:13 GMT

New page: '''Unreleased structure''' The entry 6lnm is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6lnm is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]