6log - Revision history

OCA at 14:39, 29 November 2023

OCA — Wed, 29 Nov 2023 14:39:01 GMT

←Older revision		Revision as of 14:39, 29 November 2023
Line 3:		Line 3:
	<StructureSection load='6log' size='340' side='right'caption='[[6log]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='6log' size='340' side='right'caption='[[6log]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6log]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LOG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6LOG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6log]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LOG FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CCL5~~, ~~D17S136E, SCYA5 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6log FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6log OCA], [~~http~~://pdbe.org/6log PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6log RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6log PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6log ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6log FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6log OCA], [https://pdbe.org/6log PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6log RCSB], [https://www.ebi.ac.uk/pdbsum/6log PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6log ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CCL5_HUMAN CCL5_HUMAN]] Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.<ref>PMID:16791620</ref> <ref>PMID:1380064</ref> <ref>PMID:8525373</ref> <ref>PMID:9516414</ref> <ref>PMID:15923218</ref>	+	[https://www.uniprot.org/uniprot/CCL5_HUMAN CCL5_HUMAN] Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.<ref>PMID:16791620</ref> <ref>PMID:1380064</ref> <ref>PMID:8525373</ref> <ref>PMID:9516414</ref> <ref>PMID:15923218</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen~~, Y C~~]]	+	[[Category: Chen YC]]
-	[[Category: Huang~~, C H~~]]	+	[[Category: Huang CH]]
-	[[Category: Li~~, J Y~~]]	+	[[Category: Li JY]]
-	[[Category: Sue~~, S C]]~~	+	[[Category: Sue SC]]
-	~~[[Category: Ccl5]]~~	+
-	~~[[Category: Ccl5 mutant]]~~	+
-	~~[[Category: Chemokine]]~~	+
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Rante]]~~	+
-	~~[[Category: Sulfate binding~~]]	+

OCA at 20:42, 28 October 2020

OCA — Wed, 28 Oct 2020 20:42:02 GMT

←Older revision		Revision as of 20:42, 28 October 2020
Line 3:		Line 3:
	<StructureSection load='6log' size='340' side='right'caption='[[6log]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='6log' size='340' side='right'caption='[[6log]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6log]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LOG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6LOG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6log]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LOG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LOG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6log FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6log OCA], [http://pdbe.org/6log PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6log RCSB], [http://www.ebi.ac.uk/pdbsum/6log PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6log ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCL5, D17S136E, SCYA5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6log FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6log OCA], [http://pdbe.org/6log PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6log RCSB], [http://www.ebi.ac.uk/pdbsum/6log PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6log ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chen, Y C]]		[[Category: Chen, Y C]]

OCA at 09:41, 18 March 2020

OCA — Wed, 18 Mar 2020 09:41:20 GMT

←Older revision		Revision as of 09:41, 18 March 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6log is ~~ON HOLD~~	+	==Crystal structure of human CCL5-12AAA14 mutant==
		+	<StructureSection load='6log' size='340' side='right'caption='[[6log]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6log]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LOG FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6log FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6log OCA], [http://pdbe.org/6log PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6log RCSB], [http://www.ebi.ac.uk/pdbsum/6log PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6log ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CCL5_HUMAN CCL5_HUMAN]] Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.<ref>PMID:16791620</ref> <ref>PMID:1380064</ref> <ref>PMID:8525373</ref> <ref>PMID:9516414</ref> <ref>PMID:15923218</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CC-type chemokine ligand 5 (CCL5) has been known to regulate immune responses by mediating the chemotaxis of leukocytes. Depending on the environment, CCL5 forms different orders of oligomers to interact with targets and create functional diversity. A recent CCL5 trimer structure revealed that the N-terminal conversed F12-A13-Y14 ((12)FAY(14)) sequence is involved in CCL5 aggregation. The CCL5-(12)AAA(14) mutant with two mutations had a deficiency in the formation of high-order oligomers. In the study, we clarify the respective roles of F12 and Y14 through NMR analysis and structural determination of the CCL5-(12)AAA(14) mutant where F12 is involved in the dimer assembly and Y14 is involved in aggregation. The CCL5-(12)AAA(14) structure contains a unique dimer packing. The backbone pairing shifts for one-residue in the N-terminal interface, when compared to the native CCL5 dimer. This difference creates a new structural orientation and leads to the conclusion that F12 confines the native CCL5 dimer configuration. Without F12 anchoring in the position, the interfacial backbone pairing is permitted to slide. Structural plasticity occurs in the N-terminal interaction. This is the first case to report this structural rearrangement through mutagenesis. The study provides a new idea for chemokine engineering and complements the understanding of CCL5 oligomerization and the role of the (12)FAY(14) sequence.

-	~~Authors~~:	+	N-terminal Backbone Pairing Shifts in CCL5-(12)AAA(14) Dimer Interface: Structural Significance of the FAY Sequence.,Li JY, Chen YC, Lee YZ, Huang CH, Sue SC Int J Mol Sci. 2020 Mar 1;21(5). pii: ijms21051689. doi: 10.3390/ijms21051689. PMID:32121575<ref>PMID:32121575</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6log" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chen, Y C]]
		+	[[Category: Huang, C H]]
		+	[[Category: Li, J Y]]
		+	[[Category: Sue, S C]]
		+	[[Category: Ccl5]]
		+	[[Category: Ccl5 mutant]]
		+	[[Category: Chemokine]]
		+	[[Category: Cytokine]]
		+	[[Category: Dimer]]
		+	[[Category: Rante]]
		+	[[Category: Sulfate binding]]

OCA at 05:25, 4 March 2020

OCA — Wed, 04 Mar 2020 05:25:59 GMT

←Older revision		Revision as of 05:25, 4 March 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6log is ON HOLD ~~until Jan 05 2022~~	+	The entry 6log is ON HOLD

	Authors:		Authors:

OCA at 05:07, 19 February 2020

OCA — Wed, 19 Feb 2020 05:07:04 GMT

←Older revision		Revision as of 05:07, 19 February 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6log is ON HOLD	+	The entry 6log is ON HOLD until Jan 05 2022

	Authors:		Authors:

OCA at 02:29, 13 February 2020

OCA — Thu, 13 Feb 2020 02:29:43 GMT

←Older revision		Revision as of 02:29, 13 February 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6log is ON HOLD ~~until Jan 05 2022~~	+	The entry 6log is ON HOLD

	Authors:		Authors:

OCA: Protected "6log" [edit=sysop:move=sysop]

OCA — Wed, 22 Jan 2020 13:33:11 GMT

Protected "6log" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:33, 22 January 2020

OCA: New page: '''Unreleased structure''' The entry 6log is ON HOLD until Jan 05 2022 Authors: Description: Category: Unreleased Structures

OCA — Wed, 22 Jan 2020 13:33:10 GMT

New page: '''Unreleased structure''' The entry 6log is ON HOLD until Jan 05 2022 Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6log is ON HOLD until Jan 05 2022

Authors:

Description:
[[Category: Unreleased Structures]]