6lvs - Revision history

OCA at 14:57, 29 November 2023

OCA — Wed, 29 Nov 2023 14:57:43 GMT

←Older revision		Revision as of 14:57, 29 November 2023
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	<StructureSection load='6lvs' size='340' side='right'caption='[[6lvs]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='6lvs' size='340' side='right'caption='[[6lvs]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6lvs]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LVS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6LVS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lvs]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LVS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.73Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6lvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lvs OCA], [~~http~~://pdbe.org/6lvs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6lvs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6lvs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6lvs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lvs OCA], [https://pdbe.org/6lvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lvs RCSB], [https://www.ebi.ac.uk/pdbsum/6lvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lvs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/UBP14_HUMAN UBP14_HUMAN]] Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).<ref>PMID:18162577</ref> <ref>PMID:19135427</ref> <ref>PMID:19106094</ref>	+	[https://www.uniprot.org/uniprot/UBP14_HUMAN UBP14_HUMAN] Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).<ref>PMID:18162577</ref> <ref>PMID:19135427</ref> <ref>PMID:19106094</ref>
		+
		+	==See Also==
		+	*[[Thioesterase 3D structures\|Thioesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Ubiquitinyl hydrolase 1]]~~	+	[[Category: Chou CY]]
-	[[Category: Chou~~, C Y~~]]	+	[[Category: Lin HC]]
-	[[Category: Lin~~, H C~~]]	+	[[Category: Lin TH]]
-	[[Category: Lin~~, T H]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Protein deubiquitination]]~~	+
-	~~[[Category: Ubiquitin dependent protein catabolic process~~]]	+

OCA at 09:41, 18 March 2020

OCA — Wed, 18 Mar 2020 09:41:41 GMT

←Older revision		Revision as of 09:41, 18 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6lvs is ~~ON HOLD until Mar 03 2021~~	+	==USP14 catalytic domain mutant C114S==
-		+	<StructureSection load='6lvs' size='340' side='right'caption='[[6lvs]], [[Resolution\|resolution]] 2.73Å' scene=''>
-	~~Authors~~: ~~Lin~~, H.C., ~~Lin~~, T.H., ~~Chou~~, C.Y.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6lvs]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LVS FirstGlance]. <br>
-	~~Description~~: ~~USP14 catalytic domain mutant C114S~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
-	[[Category: Chou, C.Y]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6lvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lvs OCA], [http://pdbe.org/6lvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lvs RCSB], [http://www.ebi.ac.uk/pdbsum/6lvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lvs ProSAT]</span></td></tr>
-	[[Category: Lin, H.C]]	+	</table>
-	[[Category: Lin, T.H]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UBP14_HUMAN UBP14_HUMAN]] Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).<ref>PMID:18162577</ref> <ref>PMID:19135427</ref> <ref>PMID:19106094</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ubiquitinyl hydrolase 1]]
		+	[[Category: Chou, C Y]]
		+	[[Category: Lin, H C]]
		+	[[Category: Lin, T H]]
		+	[[Category: Hydrolase]]
		+	[[Category: Protein deubiquitination]]
		+	[[Category: Ubiquitin dependent protein catabolic process]]

OCA at 05:26, 4 March 2020

OCA — Wed, 04 Mar 2020 05:26:22 GMT

←Older revision		Revision as of 05:26, 4 March 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6lvs is ON HOLD	+	The entry 6lvs is ON HOLD until Mar 03 2021

	Authors: Lin, H.C., Lin, T.H., Chou, C.Y.		Authors: Lin, H.C., Lin, T.H., Chou, C.Y.

-	Description: USP14 catalytic domain mutant ~~C113S~~	+	Description: USP14 catalytic domain mutant C114S
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Lin, T.H]]
	[[Category: Chou, C.Y]]		[[Category: Chou, C.Y]]
	[[Category: Lin, H.C]]		[[Category: Lin, H.C]]
		+	[[Category: Lin, T.H]]

OCA: Protected "6lvs" [edit=sysop:move=sysop]

OCA — Thu, 13 Feb 2020 02:34:26 GMT

Protected "6lvs" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:34, 13 February 2020

OCA: New page: '''Unreleased structure''' The entry 6lvs is ON HOLD Authors: Lin, H.C., Lin, T.H., Chou, C.Y. Description: USP14 catalytic domain mutant C113S Category: Unreleased Structures [[Ca...

OCA — Thu, 13 Feb 2020 02:34:24 GMT

New page: '''Unreleased structure''' The entry 6lvs is ON HOLD Authors: Lin, H.C., Lin, T.H., Chou, C.Y. Description: USP14 catalytic domain mutant C113S Category: Unreleased Structures [[Ca...

New page

'''Unreleased structure'''

The entry 6lvs is ON HOLD

Authors: Lin, H.C., Lin, T.H., Chou, C.Y.

Description: USP14 catalytic domain mutant C113S
[[Category: Unreleased Structures]]
[[Category: Lin, T.H]]
[[Category: Chou, C.Y]]
[[Category: Lin, H.C]]