6lvx - Revision history

OCA at 14:58, 29 November 2023

OCA — Wed, 29 Nov 2023 14:58:00 GMT

←Older revision		Revision as of 14:58, 29 November 2023
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	==Crystal structure of TLR7/Cpd-1 (SM-374527) complex==		==Crystal structure of TLR7/Cpd-1 (SM-374527) complex==
-	<StructureSection load='6lvx' size='340' side='right'caption='[[6lvx]]' scene=''>	+	<StructureSection load='6lvx' size='340' side='right'caption='[[6lvx]], [[Resolution\|resolution]] 2.77Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LVX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6LVX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LVX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6lvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lvx OCA], [~~http~~://pdbe.org/6lvx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6lvx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6lvx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6lvx ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.77Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EWL:6-azanyl-2-butoxy-9-(phenylmethyl)-7H-purin-8-one'>EWL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lvx OCA], [https://pdbe.org/6lvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lvx RCSB], [https://www.ebi.ac.uk/pdbsum/6lvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lvx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B3Y653_MACMU B3Y653_MACMU]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Toll-like receptor 7 (TLR7) recognizes both microbial and endogenous RNAs and nucleosides. Aberrant activation of TLR7 has been implicated in several autoimmune diseases including systemic lupus erythematosus (SLE). Here, by modifying potent TLR7 agonists, we develop a series of TLR7-specific antagonists as promising therapeutic agents for SLE. These compounds protect mice against lethal autoimmunity. Combining crystallography and cryo-electron microscopy, we identify the open conformation of the receptor and reveal the structural equilibrium between open and closed conformations that underlies TLR7 antagonism, as well as the detailed mechanism by which TLR7-specific antagonists bind to their binding pocket in TLR7. Our work provides small-molecule TLR7-specific antagonists and suggests the TLR7-targeting strategy for treating autoimmune diseases.
		+
		+	Structural analysis reveals TLR7 dynamics underlying antagonism.,Tojo S, Zhang Z, Matsui H, Tahara M, Ikeguchi M, Kochi M, Kamada M, Shigematsu H, Tsutsumi A, Adachi N, Shibata T, Yamamoto M, Kikkawa M, Senda T, Isobe Y, Ohto U, Shimizu T Nat Commun. 2020 Oct 15;11(1):5204. doi: 10.1038/s41467-020-19025-z. PMID:33060576<ref>PMID:33060576</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6lvx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Macaca mulatta]]
	[[Category: Ohto U]]		[[Category: Ohto U]]
	[[Category: Shimizu T]]		[[Category: Shimizu T]]
	[[Category: Zhang Z]]		[[Category: Zhang Z]]

OCA at 07:57, 11 November 2020

OCA — Wed, 11 Nov 2020 07:57:49 GMT

←Older revision		Revision as of 07:57, 11 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6lvx is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of TLR7/Cpd-1 (SM-374527) complex==
-		+	<StructureSection load='6lvx' size='340' side='right'caption='[[6lvx]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LVX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LVX FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lvx OCA], [http://pdbe.org/6lvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lvx RCSB], [http://www.ebi.ac.uk/pdbsum/6lvx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lvx ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ohto U]]
		+	[[Category: Shimizu T]]
		+	[[Category: Zhang Z]]

OCA at 08:31, 23 September 2020

OCA — Wed, 23 Sep 2020 08:31:25 GMT

←Older revision		Revision as of 08:31, 23 September 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6lvx is ON HOLD	+	The entry 6lvx is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6lvx" [edit=sysop:move=sysop]

OCA — Thu, 13 Feb 2020 02:34:58 GMT

Protected "6lvx" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:34, 13 February 2020

OCA: New page: '''Unreleased structure''' The entry 6lvx is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 13 Feb 2020 02:34:57 GMT

New page: '''Unreleased structure''' The entry 6lvx is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6lvx is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]