6lw5 - Revision history

OCA at 14:58, 29 November 2023

OCA — Wed, 29 Nov 2023 14:58:56 GMT

←Older revision		Revision as of 14:58, 29 November 2023
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	<StructureSection load='6lw5' size='340' side='right'caption='[[6lw5]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6lw5' size='340' side='right'caption='[[6lw5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6lw5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LW5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6LW5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lw5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LW5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CLR:CHOLESTEROL'>CLR</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=QXV:'>QXV</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=QXV:D-methioninamide'>QXV</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6lw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lw5 OCA], [~~http~~://pdbe.org/6lw5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6lw5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6lw5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6lw5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lw5 OCA], [https://pdbe.org/6lw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lw5 RCSB], [https://www.ebi.ac.uk/pdbsum/6lw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lw5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.	+	[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/FPR2_HUMAN FPR2_HUMAN] Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).[UniProtKB:O88536]<ref>PMID:1374236</ref> <ref>PMID:9547339</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, T]]	+	[[Category: Synthetic construct]]
-	[[Category: Wang, M]]	+	[[Category: Chen T]]
-	[[Category: Wu, B]]	+	[[Category: Wang M]]
-	[[Category: Zhang, H]]	+	[[Category: Wu B]]
-	[[Category: Zhao, Q]]	+	[[Category: Zhang H]]
-	[[Category: Zong, X]]	+	[[Category: Zhao Q]]
-	~~[[Category: Complex]]~~	+	[[Category: Zong X]]
-	~~[[Category: Formyl peptide receptor]]~~	+
-	~~[[Category: G protein-coupled receptor]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Peptide agonist~~]]	+

OCA at 10:09, 27 March 2020

OCA — Fri, 27 Mar 2020 10:09:55 GMT

←Older revision		Revision as of 10:09, 27 March 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6lw5 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the human formyl peptide receptor 2 in complex with WKYMVm==
		+	<StructureSection load='6lw5' size='340' side='right'caption='[[6lw5]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6lw5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LW5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=QXV:'>QXV</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6lw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lw5 OCA], [http://pdbe.org/6lw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lw5 RCSB], [http://www.ebi.ac.uk/pdbsum/6lw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lw5 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human formyl peptide receptor 2 (FPR2) plays a crucial role in host defense and inflammation, and has been considered as a drug target for chronic inflammatory diseases. A variety of peptides with different structures and origins have been characterized as FPR2 ligands. However, the ligand-binding modes of FPR2 remain elusive, thereby limiting the development of potential drugs. Here we report the crystal structure of FPR2 bound to the potent peptide agonist WKYMVm at 2.8 A resolution. The structure adopts an active conformation and exhibits a deep ligand-binding pocket. Combined with mutagenesis, ligand binding and signaling studies, key interactions between the agonist and FPR2 that govern ligand recognition and receptor activation are identified. Furthermore, molecular docking and functional assays reveal key factors that may define binding affinity and agonist potency of formyl peptides. These findings deepen our understanding about ligand recognition and selectivity mechanisms of the formyl peptide receptor family.

-	~~Authors~~:	+	Structural basis of ligand binding modes at the human formyl peptide receptor 2.,Chen T, Xiong M, Zong X, Ge Y, Zhang H, Wang M, Won Han G, Yi C, Ma L, Ye RD, Xu Y, Zhao Q, Wu B Nat Commun. 2020 Mar 5;11(1):1208. doi: 10.1038/s41467-020-15009-1. PMID:32139677<ref>PMID:32139677</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6lw5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chen, T]]
		+	[[Category: Wang, M]]
		+	[[Category: Wu, B]]
		+	[[Category: Zhang, H]]
		+	[[Category: Zhao, Q]]
		+	[[Category: Zong, X]]
		+	[[Category: Complex]]
		+	[[Category: Formyl peptide receptor]]
		+	[[Category: G protein-coupled receptor]]
		+	[[Category: Membrane protein]]
		+	[[Category: Peptide agonist]]

OCA at 05:08, 19 February 2020

OCA — Wed, 19 Feb 2020 05:08:20 GMT

←Older revision		Revision as of 05:08, 19 February 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6lw5 is ON HOLD	+	The entry 6lw5 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6lw5" [edit=sysop:move=sysop]

OCA — Thu, 13 Feb 2020 02:35:33 GMT

Protected "6lw5" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:35, 13 February 2020

OCA: New page: '''Unreleased structure''' The entry 6lw5 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 13 Feb 2020 02:35:32 GMT

New page: '''Unreleased structure''' The entry 6lw5 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6lw5 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]