6lyw - Revision history

OCA at 15:05, 29 November 2023

OCA — Wed, 29 Nov 2023 15:05:21 GMT

←Older revision		Revision as of 15:05, 29 November 2023
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	<StructureSection load='6lyw' size='340' side='right'caption='[[6lyw]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6lyw' size='340' side='right'caption='[[6lyw]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6lyw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LYW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6LYW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lyw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LYW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6lyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lyw OCA], [~~http~~://pdbe.org/6lyw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6lyw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6lyw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6lyw ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lyw OCA], [https://pdbe.org/6lyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lyw RCSB], [https://www.ebi.ac.uk/pdbsum/6lyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lyw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TRL21_ARATH TRL21_ARATH]] Thiol-disulfide oxidoreductase that may participate in various redox reactions. Possesses insulin disulfide bonds reducing activity.<ref>PMID:19109414</ref>	+	[https://www.uniprot.org/uniprot/TRL21_ARATH TRL21_ARATH] Thiol-disulfide oxidoreductase that may participate in various redox reactions. Possesses insulin disulfide bonds reducing activity.<ref>PMID:19109414</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Large Structures]]
-	[[Category: Pan, W M]]
-	[[Category: Wang, J C]]
-	[[Category: Wang, M Z]]
-	[[Category: Zhang, M]]
-	[[Category: 2-cys prxa]]
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
-	[[Category: ~~Peroxidase activity~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Structural protein~~]]	+	[[Category: Pan WM]]
		+	[[Category: Wang JC]]
		+	[[Category: Wang MZ]]
		+	[[Category: Zhang M]]

OCA at 06:00, 20 May 2020

OCA — Wed, 20 May 2020 06:00:35 GMT

←Older revision		Revision as of 06:00, 20 May 2020
Line 1:		Line 1:

	==Structural insight into the biological functions of Arabidopsis thaliana ACHT1==		==Structural insight into the biological functions of Arabidopsis thaliana ACHT1==
-	<StructureSection load='6lyw' size='340' side='right'caption='[[6lyw]]' scene=''>	+	<StructureSection load='6lyw' size='340' side='right'caption='[[6lyw]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LYW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LYW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lyw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LYW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LYW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lyw OCA], [http://pdbe.org/6lyw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lyw RCSB], [http://www.ebi.ac.uk/pdbsum/6lyw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lyw ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lyw OCA], [http://pdbe.org/6lyw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lyw RCSB], [http://www.ebi.ac.uk/pdbsum/6lyw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lyw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRL21_ARATH TRL21_ARATH]] Thiol-disulfide oxidoreductase that may participate in various redox reactions. Possesses insulin disulfide bonds reducing activity.<ref>PMID:19109414</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Arabidopsis thaliana atypical Cys His-rich thioredoxins (ACHTs) are a small class of atypical thioredoxins (TRXs) located in chloroplasts thylakoids and are characterized by a noncanonical motif at their redox active site, C (G/S)(S/G)C. Previous studies have reported that ACHT1 can interact with A. thaliana 2-Cys peroxiredoxins (2-Cys Prxs, including PrxA and PrxB) to transmit oxidation signals in response to illumination with normal light intensity. In this study, we reported the crystal structure of ACHT1 and show that ACHT1 adopts a canonical TRX fold. Comparison of the structures of ACHT1 in both reducing and oxidizing environments revealed that while the redox environment did not influence the overall structure of ACHT1, it did change the conformation of its catalytic residues. We found that the catalytic C125 of ACHT1 is the target residue for PrxA in vitro. In addition, we found that ACHT1 can reduce the peroxidase activity of PrxA, and further confirmed that the ability of ACHT1 to restore the peroxidase function of PrxA was due to the interaction between the two. Our results provide a structural basis for studying the function of atypical TRXs and the oxidative regulation mechanism of ACHT1 and 2-Cys Prxs in chloroplasts.
		+
		+	Structural insight into the biological functions of Arabidopsis thaliana ACHT1.,Wang J, Pan W, Cai W, Wang M, Liu L, Zhang M Int J Biol Macromol. 2020 May 3;158:43-51. doi: 10.1016/j.ijbiomac.2020.04.246. PMID:32376247<ref>PMID:32376247</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6lyw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Pan WM]]	+	[[Category: Pan, W M]]
-	[[Category: Wang JC]]	+	[[Category: Wang, J C]]
-	[[Category: Wang MZ]]	+	[[Category: Wang, M Z]]
-	[[Category: Zhang M]]	+	[[Category: Zhang, M]]
		+	[[Category: 2-cys prxa]]
		+	[[Category: Arabidopsis thaliana]]
		+	[[Category: Peroxidase activity]]
		+	[[Category: Structural protein]]

OCA at 05:26, 13 May 2020

OCA — Wed, 13 May 2020 05:26:07 GMT

←Older revision		Revision as of 05:26, 13 May 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6lyw ~~is ON HOLD until Paper Publication~~	+	==Structural insight into the biological functions of Arabidopsis thaliana ACHT1==
-		+	<StructureSection load='6lyw' size='340' side='right'caption='[[6lyw]]' scene=''>
-	~~Authors~~: ~~Wang~~, J.C., ~~Pan~~, W.M., ~~Wang, M~~.Z., ~~Zhang, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LYW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LYW FirstGlance]. <br>
-	~~Description: Structural insight into the biological functions of Arabidopsis thaliana ACHT1~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lyw OCA], [http://pdbe.org/6lyw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lyw RCSB], [http://www.ebi.ac.uk/pdbsum/6lyw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lyw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Zhang, M~~]]	+	__TOC__
-	[[Category: ~~Pan, W.M~~]]	+	</StructureSection>
-	[[Category: Wang~~, J.C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Wang,~~ M.Z]]	+	[[Category: Pan WM]]
		+	[[Category: Wang JC]]
		+	[[Category: Wang MZ]]
		+	[[Category: Zhang M]]

OCA: Protected "6lyw" [edit=sysop:move=sysop]

OCA — Wed, 26 Feb 2020 08:00:55 GMT

Protected "6lyw" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:00, 26 February 2020

OCA: New page: '''Unreleased structure''' The entry 6lyw is ON HOLD until Paper Publication Authors: Wang, J.C., Pan, W.M., Wang, M.Z., Zhang, M. Description: Structural insight into the biological f...

OCA — Wed, 26 Feb 2020 08:00:54 GMT

New page: '''Unreleased structure''' The entry 6lyw is ON HOLD until Paper Publication Authors: Wang, J.C., Pan, W.M., Wang, M.Z., Zhang, M. Description: Structural insight into the biological f...

New page

'''Unreleased structure'''

The entry 6lyw is ON HOLD until Paper Publication

Authors: Wang, J.C., Pan, W.M., Wang, M.Z., Zhang, M.

Description: Structural insight into the biological functions of Arabidopsis thaliana ACHT1
[[Category: Unreleased Structures]]
[[Category: Zhang, M]]
[[Category: Pan, W.M]]
[[Category: Wang, J.C]]
[[Category: Wang, M.Z]]