6lzb - Revision history

OCA at 15:06, 29 November 2023

OCA — Wed, 29 Nov 2023 15:06:12 GMT

←Older revision		Revision as of 15:06, 29 November 2023
Line 3:		Line 3:
	<StructureSection load='6lzb' size='340' side='right'caption='[[6lzb]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='6lzb' size='340' side='right'caption='[[6lzb]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6lzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LZB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EYF:1-[(3-methoxyphenyl)methyl]-~{N}-oxidanyl-pyrrolo[2,3-b]pyridine-5-carboxamide'>EYF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.29Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METAP1, KIAA0094 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EYF:1-[(3-methoxyphenyl)methyl]-~{N}-oxidanyl-pyrrolo[2,3-b]pyridine-5-carboxamide'>EYF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzb OCA], [https://pdbe.org/6lzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lzb RCSB], [https://www.ebi.ac.uk/pdbsum/6lzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzb OCA], [https://pdbe.org/6lzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lzb RCSB], [https://www.ebi.ac.uk/pdbsum/6lzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MAP11_HUMAN MAP11_HUMAN]] Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.[HAMAP-Rule:MF_03174]<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>	+	[https://www.uniprot.org/uniprot/MAP11_HUMAN MAP11_HUMAN] Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.[HAMAP-Rule:MF_03174]<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Methionyl aminopeptidase]]~~	+	[[Category: Addlagatta A]]
-	[[Category: Addlagatta, A]]	+	[[Category: Sandeep CB]]
-	[[Category: Sandeep~~, C B]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Methionine aminopeptidase~~]]	+

OCA at 06:13, 18 August 2021

OCA — Wed, 18 Aug 2021 06:13:38 GMT

←Older revision		Revision as of 06:13, 18 August 2021
Line 1:		Line 1:

	==crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with AN-P2-5H-06==		==crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with AN-P2-5H-06==
-	<StructureSection load='6lzb' size='340' side='right'caption='[[6lzb]]' scene=''>	+	<StructureSection load='6lzb' size='340' side='right'caption='[[6lzb]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LZB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzb OCA], [https://pdbe.org/6lzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lzb RCSB], [https://www.ebi.ac.uk/pdbsum/6lzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzb ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EYF:1-[(3-methoxyphenyl)methyl]-~{N}-oxidanyl-pyrrolo[2,3-b]pyridine-5-carboxamide'>EYF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METAP1, KIAA0094 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzb OCA], [https://pdbe.org/6lzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lzb RCSB], [https://www.ebi.ac.uk/pdbsum/6lzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/MAP11_HUMAN MAP11_HUMAN]] Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.[HAMAP-Rule:MF_03174]<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Methionine aminopeptidases (MetAPs) are an important class of enzymes that work co-translationally for the removal of initiator methionine. Chemical inhibition or gene knockdown is lethal to the microbes suggesting that they can be used as antibiotic targets. However, sequence and structural similarity between the microbial and host MetAPs has been a challenge in the identification of selective inhibitors. In this study, we have analyzed several thousands of MetAP sequences and established a pattern of variation in the S1 pocket of the enzyme. Based on this knowledge, we have designed a library of 17 azaindole based hydroxamic acid derivatives which selectively inhibited the MetAP from H. pylori compared to the human counterpart. Structural studies provided the molecular basis for the selectivity.
		+
		+	Selective inhibition of Helicobacter pylori methionine aminopeptidase by azaindole hydroxamic acid derivatives: Design, synthesis, in vitro biochemical and structural studies.,Bala S, Yellamanda KV, Kadari A, Ravinuthala VSU, Kattula B, Singh OV, Gundla R, Addlagatta A Bioorg Chem. 2021 Jul 21;115:105185. doi: 10.1016/j.bioorg.2021.105185. PMID:34329997<ref>PMID:34329997</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6lzb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminopeptidase 3D structures\|Aminopeptidase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Addlagatta A]]	+	[[Category: Methionyl aminopeptidase]]
-	[[Category: Sandeep CB]]	+	[[Category: Addlagatta, A]]
		+	[[Category: Sandeep, C B]]
		+	[[Category: Hydrolase]]
		+	[[Category: Methionine aminopeptidase]]

OCA at 06:38, 24 February 2021

OCA — Wed, 24 Feb 2021 06:38:03 GMT

←Older revision		Revision as of 06:38, 24 February 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6lzb is ON HOLD until Paper Publication~~	+	==crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with AN-P2-5H-06==
-		+	<StructureSection load='6lzb' size='340' side='right'caption='[[6lzb]]' scene=''>
-	~~Authors: sandeep, C.B., Addlagatta, A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LZB FirstGlance]. <br>
-	~~Description:~~ crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with AN-P2-5H-06	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzb OCA], [https://pdbe.org/6lzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lzb RCSB], [https://www.ebi.ac.uk/pdbsum/6lzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzb ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Addlagatta, A]]	+	__TOC__
-	[[Category: Sandeep~~, C.B~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Addlagatta A]]
		+	[[Category: Sandeep CB]]

OCA at 08:14, 27 March 2020

OCA — Fri, 27 Mar 2020 08:14:22 GMT

←Older revision		Revision as of 08:14, 27 March 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6lzb is ON HOLD	+	The entry 6lzb is ON HOLD until Paper Publication

	Authors: sandeep, C.B., Addlagatta, A.		Authors: sandeep, C.B., Addlagatta, A.

OCA: Protected "6lzb" [edit=sysop:move=sysop]

OCA — Wed, 26 Feb 2020 08:01:50 GMT

Protected "6lzb" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:01, 26 February 2020

OCA: New page: '''Unreleased structure''' The entry 6lzb is ON HOLD Authors: sandeep, C.B., Addlagatta, A. Description: crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex wit...

OCA — Wed, 26 Feb 2020 08:01:49 GMT

New page: '''Unreleased structure''' The entry 6lzb is ON HOLD Authors: sandeep, C.B., Addlagatta, A. Description: crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex wit...

New page

'''Unreleased structure'''

The entry 6lzb is ON HOLD

Authors: sandeep, C.B., Addlagatta, A.

Description: crystal structure of Human Methionine aminopeptidase (HsMetAP1b) in complex with AN-P2-5H-06
[[Category: Unreleased Structures]]
[[Category: Addlagatta, A]]
[[Category: Sandeep, C.B]]