6lzl - Revision history

OCA at 10:47, 27 March 2024

OCA — Wed, 27 Mar 2024 10:47:56 GMT

←Older revision		Revision as of 10:47, 27 March 2024
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	==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine==		==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine==
-	<StructureSection load='6lzl' size='340' side='right'caption='[[6lzl]]' scene=''>	+	<StructureSection load='6lzl' size='340' side='right'caption='[[6lzl]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6LZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6lzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LZL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzl OCA], [~~http~~://pdbe.org/6lzl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6lzl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6lzl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYR:(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one'>AYR</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzl OCA], [https://pdbe.org/6lzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lzl RCSB], [https://www.ebi.ac.uk/pdbsum/6lzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
		+
		+	==See Also==
		+	*[[Dihydroorotate dehydrogenase 3D structures\|Dihydroorotate dehydrogenase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Huang J]]		[[Category: Huang J]]

OCA at 06:52, 15 April 2020

OCA — Wed, 15 Apr 2020 06:52:48 GMT

←Older revision		Revision as of 06:52, 15 April 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6lzl ~~is ON HOLD until Apr 15 2021~~	+	==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine==
-		+	<StructureSection load='6lzl' size='340' side='right'caption='[[6lzl]]' scene=''>
-	~~Authors~~: ~~Liu~~, Z.H., Wu, D., ~~Lu, W~~.Q., ~~Huang, J~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LZL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LZL FirstGlance]. <br>
-	~~Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lzl OCA], [http://pdbe.org/6lzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lzl RCSB], [http://www.ebi.ac.uk/pdbsum/6lzl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lzl ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Liu, Z.H~~]]	+	__TOC__
-	[[Category: ~~Lu, W.Q~~]]	+	</StructureSection>
-	[[Category: ~~Wu, D~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Huang, J~~]]	+	[[Category: Huang J]]
		+	[[Category: Liu ZH]]
		+	[[Category: Lu WQ]]
		+	[[Category: Wu D]]

OCA at 05:55, 11 March 2020

OCA — Wed, 11 Mar 2020 05:55:50 GMT

←Older revision		Revision as of 05:55, 11 March 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6lzl is ON HOLD	+	The entry 6lzl is ON HOLD until Apr 15 2021

	Authors: Liu, Z.H., Wu, D., Lu, W.Q., Huang, J.		Authors: Liu, Z.H., Wu, D., Lu, W.Q., Huang, J.
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	Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine		Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Liu, Z.H]]
	[[Category: Lu, W.Q]]		[[Category: Lu, W.Q]]
	[[Category: Wu, D]]		[[Category: Wu, D]]
	[[Category: Huang, J]]		[[Category: Huang, J]]
-	[[Category: Liu, Z.H]]

OCA: Protected "6lzl" [edit=sysop:move=sysop]

OCA — Wed, 26 Feb 2020 08:02:33 GMT

Protected "6lzl" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:02, 26 February 2020

OCA: New page: '''Unreleased structure''' The entry 6lzl is ON HOLD Authors: Liu, Z.H., Wu, D., Lu, W.Q., Huang, J. Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with P...

OCA — Wed, 26 Feb 2020 08:02:31 GMT

New page: '''Unreleased structure''' The entry 6lzl is ON HOLD Authors: Liu, Z.H., Wu, D., Lu, W.Q., Huang, J. Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with P...

New page

'''Unreleased structure'''

The entry 6lzl is ON HOLD

Authors: Liu, Z.H., Wu, D., Lu, W.Q., Huang, J.

Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine
[[Category: Unreleased Structures]]
[[Category: Lu, W.Q]]
[[Category: Wu, D]]
[[Category: Huang, J]]
[[Category: Liu, Z.H]]