6m3y - Revision history

OCA at 09:32, 15 September 2021

OCA — Wed, 15 Sep 2021 09:32:48 GMT

←Older revision		Revision as of 09:32, 15 September 2021
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	<StructureSection load='6m3y' size='340' side='right'caption='[[6m3y]], [[Resolution\|resolution]] 1.93Å' scene=''>		<StructureSection load='6m3y' size='340' side='right'caption='[[6m3y]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6m3y]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_7469 Atcc 7469]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M3Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6M3Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6m3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_7469 Atcc 7469]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M3Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCE29_04955 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=47715 ATCC 7469])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCE29_04955 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=47715 ATCC 7469])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6m3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m3y OCA], [~~http~~://pdbe.org/6m3y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6m3y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6m3y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6m3y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m3y OCA], [https://pdbe.org/6m3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m3y RCSB], [https://www.ebi.ac.uk/pdbsum/6m3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m3y ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:31, 19 August 2020

OCA — Wed, 19 Aug 2020 06:31:17 GMT

←Older revision		Revision as of 06:31, 19 August 2020
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	==Crystal structure of pilus adhesin, SpaC from Lactobacillus rhamnosus GG - open conformation==		==Crystal structure of pilus adhesin, SpaC from Lactobacillus rhamnosus GG - open conformation==
-	<StructureSection load='6m3y' size='340' side='right'caption='[[6m3y]]' scene=''>	+	<StructureSection load='6m3y' size='340' side='right'caption='[[6m3y]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M3Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6M3Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6m3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_7469 Atcc 7469]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M3Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6M3Y FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6m3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m3y OCA], [http://pdbe.org/6m3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m3y RCSB], [http://www.ebi.ac.uk/pdbsum/6m3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m3y ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CCE29_04955 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=47715 ATCC 7469])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6m3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m3y OCA], [http://pdbe.org/6m3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m3y RCSB], [http://www.ebi.ac.uk/pdbsum/6m3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m3y ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Adhesion to cell surfaces is an essential and early prerequisite for successful host colonization by bacteria, and in most instances involves the specificities of various adhesins. Among bacterial Gram-positives, some genera and species mediate attachment to host cells by using long non-flagellar appendages called sortase-dependent pili. A case in point is the beneficial Lactobacillus rhamnosus GG gut-adapted strain that produces the so-called SpaCBA pilus, a structure noted for its promiscuous binding to intestinal mucus and collagen. Structurally, SpaCBA pili are heteropolymers of three different pilin-protein subunits, each with its own location and function in the pilus: backbone SpaA for length, basal SpaB for anchoring, and tip SpaC for adhesion. Previously, we solved the SpaA tertiary structure by X-ray crystallography and also reported on the crystallization of SpaB and SpaC. Here, we reveal the full-length high-resolution (1.9 A) crystal structure of SpaC, a first for a sortase-dependent pilus-bearing commensal. The SpaC structure, unlike the representative four-domain architecture of other Gram-positive tip pilins, espouses an atypically longer five-domain arrangement that includes N-terminal 'binding' and C-terminal 'stalk' regions of two and three domains, respectively. With the prospect of establishing new mechanistic insights, we provide a structural basis for the multi-substrate binding nature of SpaC, as well as a structural model that reconciles its exclusive localization at the SpaCBA pilus tip.
		+
		+	Crystal structure of lactobacillar SpaC reveals an atypical five-domain pilus tip adhesin: Exposing its substrate-binding and assembly in SpaCBA pili.,Kant A, Palva A, von Ossowski I, Krishnan V J Struct Biol. 2020 Jul 9:107571. doi: 10.1016/j.jsb.2020.107571. PMID:32653644<ref>PMID:32653644</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6m3y" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 7469]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kant A]]	+	[[Category: Kant, A]]
-	[[Category: Krishnan V]]	+	[[Category: Krishnan, V]]
-	[[Category: Palva A]]	+	[[Category: Ossowski, I von]]
-	[[Category: ~~Von Ossowski I~~]]	+	[[Category: Palva, A]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Fimbria]]
		+	[[Category: Lactobacillus rhamnosus gg]]
		+	[[Category: Lectin]]
		+	[[Category: Pili]]
		+	[[Category: Pilus adhesin]]
		+	[[Category: Probiotic]]
		+	[[Category: Sortase]]
		+	[[Category: Spac]]
		+	[[Category: Spacba pilus]]
		+	[[Category: Surface protein]]
		+	[[Category: Tip pilin]]
		+	[[Category: Vwfa domain]]

OCA at 11:07, 29 July 2020

OCA — Wed, 29 Jul 2020 11:07:05 GMT

←Older revision		Revision as of 11:07, 29 July 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6m3y is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of pilus adhesin, SpaC from Lactobacillus rhamnosus GG - open conformation==
-		+	<StructureSection load='6m3y' size='340' side='right'caption='[[6m3y]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M3Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6M3Y FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6m3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m3y OCA], [http://pdbe.org/6m3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m3y RCSB], [http://www.ebi.ac.uk/pdbsum/6m3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m3y ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kant A]]
		+	[[Category: Krishnan V]]
		+	[[Category: Palva A]]
		+	[[Category: Von Ossowski I]]

OCA at 04:08, 22 April 2020

OCA — Wed, 22 Apr 2020 04:08:41 GMT

←Older revision		Revision as of 04:08, 22 April 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6m3y is ON HOLD	+	The entry 6m3y is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6m3y" [edit=sysop:move=sysop]

OCA — Wed, 11 Mar 2020 06:00:07 GMT

Protected "6m3y" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:00, 11 March 2020

OCA: New page: '''Unreleased structure''' The entry 6m3y is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Mar 2020 06:00:02 GMT

New page: '''Unreleased structure''' The entry 6m3y is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6m3y is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]