6m7h - Revision history

OCA at 08:45, 27 November 2019

OCA — Wed, 27 Nov 2019 08:45:35 GMT

←Older revision		Revision as of 08:45, 27 November 2019
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	<StructureSection load='6m7h' size='340' side='right'caption='[[6m7h]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6m7h' size='340' side='right'caption='[[6m7h]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6m7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Acanthophacelus_reticulata Acanthophacelus reticulata~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M7H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6m7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M7H FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KN9:N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide'>KN9</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KN9:N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide'>KN9</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~8081 Acanthophacelus reticulata~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m7h OCA], [http://pdbe.org/6m7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m7h RCSB], [http://www.ebi.ac.uk/pdbsum/6m7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m7h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m7h OCA], [http://pdbe.org/6m7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m7h RCSB], [http://www.ebi.ac.uk/pdbsum/6m7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m7h ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acanthophacelus reticulata~~]]	+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Damo, S M]]		[[Category: Damo, S M]]

OCA at 08:23, 6 November 2019

OCA — Wed, 06 Nov 2019 08:23:35 GMT

←Older revision		Revision as of 08:23, 6 November 2019
Line 3:		Line 3:
	<StructureSection load='6m7h' size='340' side='right'caption='[[6m7h]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6m7h' size='340' side='right'caption='[[6m7h]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6m7h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M7H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6m7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthophacelus_reticulata Acanthophacelus reticulata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M7H FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KN9:N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide'>KN9</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KN9:N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide'>KN9</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALM1, CALM, CAM, CAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8081 Acanthophacelus reticulata])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m7h OCA], [http://pdbe.org/6m7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m7h RCSB], [http://www.ebi.ac.uk/pdbsum/6m7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m7h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m7h OCA], [http://pdbe.org/6m7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m7h RCSB], [http://www.ebi.ac.uk/pdbsum/6m7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m7h ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN]] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Acanthophacelus reticulata]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Damo, S M]]		[[Category: Damo, S M]]
		+	[[Category: Johnson, C N]]
	[[Category: Pattanayek, R]]		[[Category: Pattanayek, R]]
	[[Category: Ca2+ binding ef-hand inhibitor complex]]		[[Category: Ca2+ binding ef-hand inhibitor complex]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 15:30, 28 August 2019

OCA — Wed, 28 Aug 2019 15:30:46 GMT

←Older revision		Revision as of 15:30, 28 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6m7h is ~~ON HOLD until Paper~~ Publication	+	==Structure of calmodulin with KN93==
		+	<StructureSection load='6m7h' size='340' side='right'caption='[[6m7h]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6m7h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M7H FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KN9:N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide'>KN9</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m7h OCA], [http://pdbe.org/6m7h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m7h RCSB], [http://www.ebi.ac.uk/pdbsum/6m7h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m7h ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Here we report the structure of the widely utilized calmodulin (CaM)-dependent protein kinase II (CaMKII) inhibitor KN93 bound to the Ca(2+)-sensing protein CaM. KN93 is widely believed to inhibit CaMKII by binding to the kinase. The CaM-KN93 interaction is significant as it can interfere with the interaction between CaM and it's physiological targets, thereby raising the possibility of ascribing modified protein function to CaMKII phosphorylation while concealing a CaM-protein interaction. NMR spectroscopy, stopped-flow kinetic measurements, and x-ray crystallography were used to characterize the structure and biophysical properties of the CaM-KN93 interaction. We then investigated the functional properties of the cardiac Na(+) channel (NaV1.5) and ryanodine receptor (RyR2). We find that KN93 disrupts a high affinity CaM-NaV1.5 interaction and alters channel function independent of CaMKII. Moreover, KN93 increases RyR2 Ca(2+) release in cardiomyocytes independent of CaMKII. Therefore, when interpreting KN93 data, targets other than CaMKII need to be considered.

-	~~Authors: Damo, S~~.M., Pattanayek, R.	+	The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function.,Johnson CN, Pattanayek R, Potet F, Rebbeck RT, Blackwell DJ, Nikolaienko R, Sequeira V, Le Meur R, Radwanski PB, Davis JP, Zima AV, Cornea RL, Damo SM, Gyorke S, George AL Jr, Knollmann BC Cell Calcium. 2019 Sep;82:102063. doi: 10.1016/j.ceca.2019.102063. Epub 2019 Jul , 30. PMID:31401388<ref>PMID:31401388</ref>

-	~~Description: Structure~~ of ~~calmodulin with KN93~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6m7h" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Damo, S M]]
	[[Category: Pattanayek, R]]		[[Category: Pattanayek, R]]
-	[[Category: ~~Damo, S.M~~]]	+	[[Category: Ca2+ binding ef-hand inhibitor complex]]
		+	[[Category: Signaling protein]]

OCA at 05:42, 21 May 2019

OCA — Tue, 21 May 2019 05:42:35 GMT

←Older revision		Revision as of 05:42, 21 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6m7h is ON HOLD	+	The entry 6m7h is ON HOLD until Paper Publication

	Authors: Damo, S.M., Pattanayek, R.		Authors: Damo, S.M., Pattanayek, R.

OCA: Protected "6m7h" [edit=sysop:move=sysop]

OCA — Wed, 29 Aug 2018 06:03:15 GMT

Protected "6m7h" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:03, 29 August 2018

OCA: New page: '''Unreleased structure''' The entry 6m7h is ON HOLD Authors: Damo, S.M., Pattanayek, R. Description: Structure of calmodulin with KN93 Category: Unreleased Structures [[Category: ...

OCA — Wed, 29 Aug 2018 06:03:13 GMT

New page: '''Unreleased structure''' The entry 6m7h is ON HOLD Authors: Damo, S.M., Pattanayek, R. Description: Structure of calmodulin with KN93 Category: Unreleased Structures [[Category: ...

New page

'''Unreleased structure'''

The entry 6m7h is ON HOLD

Authors: Damo, S.M., Pattanayek, R.

Description: Structure of calmodulin with KN93
[[Category: Unreleased Structures]]
[[Category: Pattanayek, R]]
[[Category: Damo, S.M]]