6m97 - Revision history

OCA at 14:41, 13 March 2024

OCA — Wed, 13 Mar 2024 14:41:44 GMT

←Older revision		Revision as of 14:41, 13 March 2024
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	<StructureSection load='6m97' size='340' side='right'caption='[[6m97]], [[Resolution\|resolution]] 3.03Å' scene=''>		<StructureSection load='6m97' size='340' side='right'caption='[[6m97]], [[Resolution\|resolution]] 3.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6m97]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M97 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6M97 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6m97]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Salmo_salar Salmo salar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M97 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=TBR:HEXATANTALUM+DODECABROMIDE'>TBR</scene~~>, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.03Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~COPT1, copt1 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=562 "Bacillus coli" Migula 1895])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TBR:HEXATANTALUM+DODECABROMIDE'>TBR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m97 OCA], [~~http~~://pdbe.org/6m97 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6m97 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6m97 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6m97 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m97 OCA], [https://pdbe.org/6m97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m97 RCSB], [https://www.ebi.ac.uk/pdbsum/6m97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m97 ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/C0HAK2_SALSA C0HAK2_SALSA]
-	Copper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. Evolutionarily conserved from fungi to humans, the high-affinity Cu(+) transporter Ctr1 is crucial for both dietary Cu uptake and peripheral distribution, yet the mechanisms for selective permeation of potentially toxic Cu(+) ions across cell membranes are unknown. Here we present X-ray crystal structures of Ctr1 from Salmo salar in both Cu(+)-free and Cu(+)-bound states, revealing a homo-trimeric Cu(+)-selective ion channel-like architecture. Two layers of methionine triads form a selectivity filter, coordinating two bound Cu(+) ions close to the extracellular entrance. These structures, together with Ctr1 functional characterization, provide a high resolution picture to understand Cu(+) import across cellular membranes and suggest therapeutic opportunities for intervention in diseases characterized by inappropriate Cu accumulation.	+
-		+
-	~~X-ray structures of the high-affinity copper transporter Ctr1.,Ren F, Logeman BL, Zhang X, Liu Y, Thiele DJ, Yuan P Nat Commun. 2019 Mar 27;10(1)~~:~~1386~~. ~~doi: 10~~.~~1038~~/~~s41467~~-~~019-09376-7~~. ~~PMID~~:~~30918258<ref>PMID:30918258<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®~~/~~PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 6m97" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ren, F~~]]	+	[[Category: Salmo salar]]
-	[[Category: ~~Yuan, P~~]]	+	[[Category: Ren F]]
-	[[Category: ~~Ion channels]]~~	+	[[Category: Yuan P]]
-	~~[[Category: Ion transporter]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 07:55, 10 April 2019

OCA — Wed, 10 Apr 2019 07:55:57 GMT

←Older revision		Revision as of 07:55, 10 April 2019
Line 3:		Line 3:
	<StructureSection load='6m97' size='340' side='right'caption='[[6m97]], [[Resolution\|resolution]] 3.03Å' scene=''>		<StructureSection load='6m97' size='340' side='right'caption='[[6m97]], [[Resolution\|resolution]] 3.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6m97]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M97 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6m97]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M97 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TBR:HEXATANTALUM+DODECABROMIDE'>TBR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TBR:HEXATANTALUM+DODECABROMIDE'>TBR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">COPT1, copt1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m97 OCA], [http://pdbe.org/6m97 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m97 RCSB], [http://www.ebi.ac.uk/pdbsum/6m97 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m97 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m97 OCA], [http://pdbe.org/6m97 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m97 RCSB], [http://www.ebi.ac.uk/pdbsum/6m97 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m97 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Copper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. Evolutionarily conserved from fungi to humans, the high-affinity Cu(+) transporter Ctr1 is crucial for both dietary Cu uptake and peripheral distribution, yet the mechanisms for selective permeation of potentially toxic Cu(+) ions across cell membranes are unknown. Here we present X-ray crystal structures of Ctr1 from Salmo salar in both Cu(+)-free and Cu(+)-bound states, revealing a homo-trimeric Cu(+)-selective ion channel-like architecture. Two layers of methionine triads form a selectivity filter, coordinating two bound Cu(+) ions close to the extracellular entrance. These structures, together with Ctr1 functional characterization, provide a high resolution picture to understand Cu(+) import across cellular membranes and suggest therapeutic opportunities for intervention in diseases characterized by inappropriate Cu accumulation.
		+
		+	X-ray structures of the high-affinity copper transporter Ctr1.,Ren F, Logeman BL, Zhang X, Liu Y, Thiele DJ, Yuan P Nat Commun. 2019 Mar 27;10(1):1386. doi: 10.1038/s41467-019-09376-7. PMID:30918258<ref>PMID:30918258</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6m97" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ren, F]]		[[Category: Ren, F]]

OCA at 07:05, 3 April 2019

OCA — Wed, 03 Apr 2019 07:05:57 GMT

←Older revision		Revision as of 07:05, 3 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6m97 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the high-affinity copper transporter Ctr1==
-		+	<StructureSection load='6m97' size='340' side='right'caption='[[6m97]], [[Resolution\|resolution]] 3.03Å' scene=''>
-	~~Authors~~: ~~Ren~~, F., ~~Yuan~~, P.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6m97]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M97 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of the high~~-~~affinity copper transporter Ctr1~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TBR:HEXATANTALUM+DODECABROMIDE'>TBR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m97 OCA], [http://pdbe.org/6m97 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m97 RCSB], [http://www.ebi.ac.uk/pdbsum/6m97 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m97 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ren, F]]		[[Category: Ren, F]]
	[[Category: Yuan, P]]		[[Category: Yuan, P]]
		+	[[Category: Ion channels]]
		+	[[Category: Ion transporter]]
		+	[[Category: Membrane protein]]
		+	[[Category: Transport protein]]

OCA at 08:50, 5 September 2018

OCA — Wed, 05 Sep 2018 08:50:44 GMT

←Older revision		Revision as of 08:50, 5 September 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6m97 is ON HOLD	+	The entry 6m97 is ON HOLD until Paper Publication

	Authors: Ren, F., Yuan, P.		Authors: Ren, F., Yuan, P.
Line 7:		Line 7:
	Description: Crystal structure of the high-affinity copper transporter Ctr1		Description: Crystal structure of the high-affinity copper transporter Ctr1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Yuan, P]]
	[[Category: Ren, F]]		[[Category: Ren, F]]
		+	[[Category: Yuan, P]]

OCA: Protected "6m97" [edit=sysop:move=sysop]

OCA — Wed, 29 Aug 2018 06:09:03 GMT

Protected "6m97" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:09, 29 August 2018

OCA: New page: '''Unreleased structure''' The entry 6m97 is ON HOLD Authors: Ren, F., Yuan, P. Description: Crystal structure of the high-affinity copper transporter Ctr1 [[Category: Unreleased Struc...

OCA — Wed, 29 Aug 2018 06:09:02 GMT

New page: '''Unreleased structure''' The entry 6m97 is ON HOLD Authors: Ren, F., Yuan, P. Description: Crystal structure of the high-affinity copper transporter Ctr1 [[Category: Unreleased Struc...

New page

'''Unreleased structure'''

The entry 6m97 is ON HOLD

Authors: Ren, F., Yuan, P.

Description: Crystal structure of the high-affinity copper transporter Ctr1
[[Category: Unreleased Structures]]
[[Category: Yuan, P]]
[[Category: Ren, F]]