6mfd - Revision history

OCA at 06:30, 11 October 2023

OCA — Wed, 11 Oct 2023 06:30:27 GMT

←Older revision		Revision as of 06:30, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6mfd' size='340' side='right'caption='[[6mfd]], [[Resolution\|resolution]] 2.79Å' scene=''>		<StructureSection load='6mfd' size='340' side='right'caption='[[6mfd]], [[Resolution\|resolution]] 2.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mfd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"archangium_violaceum"_kuhlwein_and_reichenbach_1964 "archangium~~ violaceum~~" kuhlwein and reichenbach 1964~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MFD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MFD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mfd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archangium_violaceum Archangium violaceum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MFD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CO6:ISOBUTYRYL-COENZYME+A'>CO6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.794Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gphF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83451 "Archangium violaceum" Kuhlwein and Reichenbach 1964])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CO6:ISOBUTYRYL-COENZYME+A'>CO6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mfd OCA], [~~http~~://pdbe.org/6mfd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mfd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mfd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mfd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mfd OCA], [https://pdbe.org/6mfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mfd RCSB], [https://www.ebi.ac.uk/pdbsum/6mfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mfd ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/U6BSB2_9DELT U6BSB2_9DELT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Archangium violaceum ~~kuhlwein and reichenbach 1964~~]]	+	[[Category: Archangium violaceum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Skiba~~, M A~~]]	+	[[Category: Skiba MA]]
-	[[Category: Smith~~, J L~~]]	+	[[Category: Smith JL]]
-	[[Category: Tran~~, C L]]~~	+	[[Category: Tran CL]]
-	~~[[Category: Decarboxylase]]~~	+
-	~~[[Category: Lyase~~]]	+

OCA at 09:34, 1 April 2020

OCA — Wed, 01 Apr 2020 09:34:56 GMT

←Older revision		Revision as of 09:34, 1 April 2020
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mfd OCA], [http://pdbe.org/6mfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mfd RCSB], [http://www.ebi.ac.uk/pdbsum/6mfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mfd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mfd OCA], [http://pdbe.org/6mfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mfd RCSB], [http://www.ebi.ac.uk/pdbsum/6mfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mfd ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Natural product biosynthetic pathways are replete with enzymes repurposed for new catalytic functions. In some modular polyketide synthase (PKS) pathways, a GCN5-related N-acetyltransferase (GNAT)-like enzyme with an additional decarboxylation function initiates biosynthesis. Here, we probe two PKS GNAT-like domains for the dual activities of S-acyl transfer from coenzyme A (CoA) to an acyl carrier protein (ACP) and decarboxylation. The GphF and CurA GNAT-like domains selectively decarboxylate substrates that yield the anticipated pathway starter units. The GphF enzyme lacks detectable acyl transfer activity, and a crystal structure with an isobutyryl-CoA product analog reveals a partially occluded acyltransfer acceptor site. Further analysis indicates that the CurA GNAT-like domain also catalyzes only decarboxylation, and the initial acyl transfer is catalyzed by an unidentified enzyme. Thus, PKS GNAT-like domains are re-classified as GNAT-like decarboxylases. Two other decarboxylases, malonyl-CoA decarboxylase and EryM, reside on distant nodes of the superfamily, illustrating the adaptability of the GNAT fold.
		+
		+	Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis.,Skiba MA, Tran CL, Dan Q, Sikkema AP, Klaver Z, Gerwick WH, Sherman DH, Smith JL Structure. 2020 Jan 7;28(1):63-74.e4. doi: 10.1016/j.str.2019.11.004. Epub 2019, Nov 27. PMID:31785925<ref>PMID:31785925</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6mfd" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:22, 4 December 2019

OCA — Wed, 04 Dec 2019 10:22:45 GMT

←Older revision		Revision as of 10:22, 4 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6mfd is ~~ON HOLD until Paper Publication~~	+	==GphF GNAT-like decarboxylase in complex with isobutyryl-CoA==
-		+	<StructureSection load='6mfd' size='340' side='right'caption='[[6mfd]], [[Resolution\|resolution]] 2.79Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6mfd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"archangium_violaceum"_kuhlwein_and_reichenbach_1964 "archangium violaceum" kuhlwein and reichenbach 1964]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MFD FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CO6:ISOBUTYRYL-COENZYME+A'>CO6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gphF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83451 "Archangium violaceum" Kuhlwein and Reichenbach 1964])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mfd OCA], [http://pdbe.org/6mfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mfd RCSB], [http://www.ebi.ac.uk/pdbsum/6mfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mfd ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Archangium violaceum kuhlwein and reichenbach 1964]]
		+	[[Category: Large Structures]]
		+	[[Category: Skiba, M A]]
		+	[[Category: Smith, J L]]
		+	[[Category: Tran, C L]]
		+	[[Category: Decarboxylase]]
		+	[[Category: Lyase]]

OCA at 06:28, 26 September 2018

OCA — Wed, 26 Sep 2018 06:28:05 GMT

←Older revision		Revision as of 06:28, 26 September 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mfd is ON HOLD	+	The entry 6mfd is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6mfd" [edit=sysop:move=sysop]

OCA — Wed, 19 Sep 2018 18:26:36 GMT

Protected "6mfd" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:26, 19 September 2018

OCA: New page: '''Unreleased structure''' The entry 6mfd is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Sep 2018 18:26:35 GMT

New page: '''Unreleased structure''' The entry 6mfd is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6mfd is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]