6mg8 - Revision history

OCA at 12:24, 9 June 2021

OCA — Wed, 09 Jun 2021 12:24:03 GMT

←Older revision		Revision as of 12:24, 9 June 2021
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	<SX load='6mg8' size='340' side='right' viewer='molstar' caption='[[6mg8]], [[Resolution\|resolution]] 3.60Å' scene=''>		<SX load='6mg8' size='340' side='right' viewer='molstar' caption='[[6mg8]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mg8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6MG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mg8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MG8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=~~UNL~~:~~UNKNOWN+LIGAND~~'>~~UNL~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptch1, Ptch ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptch1, Ptch ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6mg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg8 OCA], [~~http~~://pdbe.org/6mg8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mg8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mg8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg8 OCA], [https://pdbe.org/6mg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mg8 RCSB], [https://www.ebi.ac.uk/pdbsum/6mg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PTC1_MOUSE PTC1_MOUSE]] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>	+	[[https://www.uniprot.org/uniprot/PTC1_MOUSE PTC1_MOUSE]] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6mg8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6mg8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Protein patched homolog 1\|Protein patched homolog 1]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:43, 11 April 2020

OCA — Sat, 11 Apr 2020 02:43:09 GMT

←Older revision		Revision as of 02:43, 11 April 2020
Line 3:		Line 3:
	<SX load='6mg8' size='340' side='right' viewer='molstar' caption='[[6mg8]], [[Resolution\|resolution]] 3.60Å' scene=''>		<SX load='6mg8' size='340' side='right' viewer='molstar' caption='[[6mg8]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MG8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptch1, Ptch ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptch1, Ptch ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg8 OCA], [http://pdbe.org/6mg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mg8 RCSB], [http://www.ebi.ac.uk/pdbsum/6mg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg8 OCA], [http://pdbe.org/6mg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mg8 RCSB], [http://www.ebi.ac.uk/pdbsum/6mg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 22:33, 6 March 2020

OCA — Fri, 06 Mar 2020 22:33:08 GMT

←Older revision		Revision as of 22:33, 6 March 2020
Line 1:		Line 1:

	==Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched==		==Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched==
-	<~~StructureSection~~ load='6mg8' size='340' side='right' caption='[[6mg8]], [[Resolution\|resolution]] 3.60Å' scene=''>	+	<SX load='6mg8' size='340' side='right' viewer='molstar' caption='[[6mg8]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MG8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MG8 FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Asarnow, D E]]		[[Category: Asarnow, D E]]

OCA at 20:35, 2 December 2018

OCA — Sun, 02 Dec 2018 20:35:34 GMT

←Older revision		Revision as of 20:35, 2 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6mg8 is ~~ON HOLD~~	+	==Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched==
		+	<StructureSection load='6mg8' size='340' side='right' caption='[[6mg8]], [[Resolution\|resolution]] 3.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6mg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MG8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptch1, Ptch ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg8 OCA], [http://pdbe.org/6mg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mg8 RCSB], [http://www.ebi.ac.uk/pdbsum/6mg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg8 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTC1_MOUSE PTC1_MOUSE]] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hedgehog protein signals mediate tissue patterning and maintenance by binding to and inactivating their common receptor Patched, a 12-transmembrane protein that otherwise would suppress the activity of the 7-transmembrane protein Smoothened. Loss of Patched function, the most common cause of basal cell carcinoma, permits unregulated activation of Smoothened and of the Hedgehog pathway. A cryo-EM structure of the Patched protein reveals striking transmembrane domain similarities to prokaryotic RND transporters. A central hydrophobic conduit with cholesterol-like contents courses through the extracellular domain and resembles that used by other RND proteins to transport substrates, suggesting Patched activity in cholesterol transport. Cholesterol activity in the inner leaflet of the plasma membrane is reduced by PTCH1 expression but rapidly restored by Hedgehog stimulation, suggesting that PTCH1 regulates Smoothened by controlling cholesterol availability.

-	~~Authors:~~ Zhang, Y., Bulkley~~, D.~~, Xin, Y., Roberts~~, K.J.~~, Asarnow~~, D.E.~~, Sharma, A., Myers~~, B.R.~~, Cho, W., Cheng, Y., Beachy, ~~P.A~~.	+	Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.,Zhang Y, Bulkley DP, Xin Y, Roberts KJ, Asarnow DE, Sharma A, Myers BR, Cho W, Cheng Y, Beachy PA Cell. 2018 Nov 15;175(5):1352-1364.e14. doi: 10.1016/j.cell.2018.10.026. Epub, 2018 Nov 8. PMID:30415841<ref>PMID:30415841</ref>

-	~~Description: Structural basis for cholesterol transport-like activity~~ of the ~~Hedgehog receptor Patched~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Cheng~~, Y]]	+	<div class="pdbe-citations 6mg8" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Roberts~~, ~~K.J~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
		+	[[Category: Asarnow, D E]]
		+	[[Category: Beachy, P A]]
	[[Category: Bulkley, D]]		[[Category: Bulkley, D]]
-	[[Category: Myers, B.R]]	+	[[Category: Cheng, Y]]
		+	[[Category: Cho, W]]
		+	[[Category: Myers, B R]]
		+	[[Category: Roberts, K J]]
	[[Category: Sharma, A]]		[[Category: Sharma, A]]
-	[[Category: Zhang, Y]]
-	[[Category: Beachy, P.A]]
	[[Category: Xin, Y]]		[[Category: Xin, Y]]
-	[[Category: ~~Asarnow~~, ~~D.E~~]]	+	[[Category: Zhang, Y]]
-	[[Category: ~~Cho, W~~]]	+	[[Category: Membrane protein]]
		+	[[Category: Receptor membrane protein]]

OCA: Protected "6mg8" [edit=sysop:move=sysop]

OCA — Wed, 19 Sep 2018 18:28:58 GMT

Protected "6mg8" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:28, 19 September 2018

OCA: New page: '''Unreleased structure''' The entry 6mg8 is ON HOLD Authors: Zhang, Y., Bulkley, D., Xin, Y., Roberts, K.J., Asarnow, D.E., Sharma, A., Myers, B.R., Cho, W., Cheng, Y., Beachy, P.A. D...

OCA — Wed, 19 Sep 2018 18:28:57 GMT

New page: '''Unreleased structure''' The entry 6mg8 is ON HOLD Authors: Zhang, Y., Bulkley, D., Xin, Y., Roberts, K.J., Asarnow, D.E., Sharma, A., Myers, B.R., Cho, W., Cheng, Y., Beachy, P.A. D...

New page

'''Unreleased structure'''

The entry 6mg8 is ON HOLD

Authors: Zhang, Y., Bulkley, D., Xin, Y., Roberts, K.J., Asarnow, D.E., Sharma, A., Myers, B.R., Cho, W., Cheng, Y., Beachy, P.A.

Description: Structural basis for cholesterol transport-like activity of the Hedgehog receptor Patched
[[Category: Unreleased Structures]]
[[Category: Cheng, Y]]
[[Category: Roberts, K.J]]
[[Category: Bulkley, D]]
[[Category: Myers, B.R]]
[[Category: Sharma, A]]
[[Category: Zhang, Y]]
[[Category: Beachy, P.A]]
[[Category: Xin, Y]]
[[Category: Asarnow, D.E]]
[[Category: Cho, W]]