6mif - Revision history

OCA at 10:54, 14 June 2023

OCA — Wed, 14 Jun 2023 10:54:39 GMT

←Older revision		Revision as of 10:54, 14 June 2023
Line 1:		Line 1:

	==Lim5 domain of PINCH1 protein==		==Lim5 domain of PINCH1 protein==
-	<StructureSection load='6mif' size='340' side='right'caption='[[6mif~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6mif' size='340' side='right'caption='[[6mif]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mif]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MIF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6MIF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mif]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MIF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIMS1, PINCH, PINCH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mif OCA], [https://pdbe.org/6mif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mif RCSB], [https://www.ebi.ac.uk/pdbsum/6mif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mif ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6mif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mif OCA], [~~http~~://pdbe.org/6mif PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mif RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mif PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mif ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LIMS1_HUMAN LIMS1_HUMAN]] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.	+	[https://www.uniprot.org/uniprot/LIMS1_HUMAN LIMS1_HUMAN] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Qin, J]]	+	[[Category: Qin J]]
-	[[Category: Vaynberg, J]]	+	[[Category: Vaynberg J]]
-	~~[[Category: Lim domain]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Zn binding~~]]	+

OCA at 06:00, 20 May 2020

OCA — Wed, 20 May 2020 06:00:44 GMT

←Older revision		Revision as of 06:00, 20 May 2020
Line 3:		Line 3:
	<StructureSection load='6mif' size='340' side='right'caption='[[6mif]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6mif' size='340' side='right'caption='[[6mif]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mif]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MIF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MIF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mif]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MIF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MIF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIMS1, PINCH, PINCH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIMS1, PINCH, PINCH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mif OCA], [http://pdbe.org/6mif PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mif RCSB], [http://www.ebi.ac.uk/pdbsum/6mif PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mif ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mif OCA], [http://pdbe.org/6mif PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mif RCSB], [http://www.ebi.ac.uk/pdbsum/6mif PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mif ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/LIMS1_HUMAN LIMS1_HUMAN]] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.		[[http://www.uniprot.org/uniprot/LIMS1_HUMAN LIMS1_HUMAN]] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dynamic communication between integrin-containing complexes (focal adhesions, FAs) and actin filaments is critical for regulating cell adhesion. Pseudokinase ILK plays a key role in this process but the underlying mechanism remains highly elusive. Here we show that by recruiting FA adaptors PINCH and Parvin into a heterotrimeric complex (IPP), ILK triggers F-actin filament bundling - a process known to generate force/mechanical signal to promote cytoskeleton reassembly and dynamic cell adhesion. Structural, biochemical, and functional analyses revealed that the F-actin bundling is orchestrated by two previously unrecognized WASP-Homology-2 actin binding motifs within IPP, one from PINCH and the other from Parvin. Strikingly, this process is also sensitized to Mg-ATP bound to the pseudoactive site of ILK and its dysregulation severely impairs stress fibers formation, cell spreading, and migration. These data identify a crucial mechanism for ILK, highlighting its uniqueness as a pseudokinase to transduce non-catalytic signal and regulate cell adhesion.
		+
		+	Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion.,Vaynberg J, Fukuda K, Lu F, Bialkowska K, Chen Y, Plow EF, Qin J Nat Commun. 2018 Oct 26;9(1):4465. doi: 10.1038/s41467-018-06906-7. PMID:30367047<ref>PMID:30367047</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6mif" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:23, 4 December 2019

OCA — Wed, 04 Dec 2019 10:23:05 GMT

←Older revision		Revision as of 10:23, 4 December 2019
Line 1:		Line 1:

	==Lim5 domain of PINCH1 protein==		==Lim5 domain of PINCH1 protein==
-	<StructureSection load='6mif' size='340' side='right' caption='[[6mif]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='6mif' size='340' side='right'caption='[[6mif]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mif]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MIF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MIF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mif]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MIF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MIF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LIMS1, PINCH, PINCH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mif OCA], [http://pdbe.org/6mif PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mif RCSB], [http://www.ebi.ac.uk/pdbsum/6mif PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mif ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mif OCA], [http://pdbe.org/6mif PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mif RCSB], [http://www.ebi.ac.uk/pdbsum/6mif PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mif ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Qin, J]]		[[Category: Qin, J]]
	[[Category: Vaynberg, J]]		[[Category: Vaynberg, J]]

OCA at 07:00, 31 October 2018

OCA — Wed, 31 Oct 2018 07:00:26 GMT

←Older revision		Revision as of 07:00, 31 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6mif is ~~ON HOLD until Paper Publication~~	+	==Lim5 domain of PINCH1 protein==
-		+	<StructureSection load='6mif' size='340' side='right' caption='[[6mif]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6mif]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MIF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MIF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mif OCA], [http://pdbe.org/6mif PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mif RCSB], [http://www.ebi.ac.uk/pdbsum/6mif PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mif ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LIMS1_HUMAN LIMS1_HUMAN]] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Qin, J]]
		+	[[Category: Vaynberg, J]]
		+	[[Category: Lim domain]]
		+	[[Category: Signaling protein]]
		+	[[Category: Zn binding]]

OCA at 06:28, 10 October 2018

OCA — Wed, 10 Oct 2018 06:28:19 GMT

←Older revision		Revision as of 06:28, 10 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mif is ON HOLD	+	The entry 6mif is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6mif" [edit=sysop:move=sysop]

OCA — Wed, 26 Sep 2018 06:35:34 GMT

Protected "6mif" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:35, 26 September 2018

OCA: New page: '''Unreleased structure''' The entry 6mif is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 Sep 2018 06:35:33 GMT

New page: '''Unreleased structure''' The entry 6mif is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6mif is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]