6mjh - Revision history

OCA at 06:32, 11 October 2023

OCA — Wed, 11 Oct 2023 06:32:59 GMT

←Older revision		Revision as of 06:32, 11 October 2023
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	<StructureSection load='6mjh' size='340' side='right'caption='[[6mjh]], [[Resolution\|resolution]] 2.06Å' scene=''>		<StructureSection load='6mjh' size='340' side='right'caption='[[6mjh]], [[Resolution\|resolution]] 2.06Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mjh]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MJH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mjh]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/pigeon/Jiangsu/K23/2013(H9N2)) Influenza A virus (A/pigeon/Jiangsu/K23/2013(H9N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MJH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'>CA</scene~~>, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.06Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjh OCA], [~~http~~://pdbe.org/6mjh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mjh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mjh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjh OCA], [https://pdbe.org/6mjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mjh RCSB], [https://www.ebi.ac.uk/pdbsum/6mjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/A0A0R5TVW3_9INFA A0A0R5TVW3_9INFA]] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.[RuleBase:RU361247]	+	[https://www.uniprot.org/uniprot/A0A0R5TVW3_9INFA A0A0R5TVW3_9INFA] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.[RuleBase:RU361247]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6mjh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6mjh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: DeGrado~~, W F~~]]	+	[[Category: DeGrado WF]]
-	[[Category: Thomaston~~, J L]]~~	+	[[Category: Thomaston JL]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Proton channel]]~~	+
-	~~[[Category: S31n]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 06:54, 26 June 2019

OCA — Wed, 26 Jun 2019 06:54:50 GMT

←Older revision		Revision as of 06:54, 26 June 2019
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-	'''Unreleased structure'''

-	The ~~entry~~ 6mjh is ~~ON HOLD until Sep 20 2020~~	+	==The S31N mutant of the influenza A M2 proton channel in two distinct conformational states==
		+	<StructureSection load='6mjh' size='340' side='right'caption='[[6mjh]], [[Resolution\|resolution]] 2.06Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6mjh]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjh OCA], [http://pdbe.org/6mjh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mjh RCSB], [http://www.ebi.ac.uk/pdbsum/6mjh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjh ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0A0R5TVW3_9INFA A0A0R5TVW3_9INFA]] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.[RuleBase:RU361247]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The amantadine-resistant S31N mutant of the influenza A M2 proton channel has become prevalent in currently circulating viruses. Here we have solved an X-ray crystal structure of M2(22-46) S31N that contains two distinct conformational states within its asymmetric unit. This structure reveals the mechanism of adamantane resistance in both conformational states of the M2 channel. In the Inward(open) conformation, the mutant Asn31 side chain faces the channel pore and sterically blocks the adamantane binding site. In the Inward(closed) conformation, Asn31 forms hydrogen bonds with carbonyls at the monomer-monomer interface, which twists the monomer helices and constricts the channel pore at the drug binding site. We also examine M2(19-49) WT and S31N using solution NMR spectroscopy, and show that distribution of the two conformational states is dependent on both detergent choice and experimental pH.

-	~~Authors~~:	+	X-ray crystal structure of the influenza A M2 proton channel S31N mutant in two conformational states: an open and shut case.,Thomaston JL, Wu Y, Polizzi N, Liu L, Wang J, DeGrado WF J Am Chem Soc. 2019 Jun 11. doi: 10.1021/jacs.9b02196. PMID:31184871<ref>PMID:31184871</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6mjh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: DeGrado, W F]]
		+	[[Category: Thomaston, J L]]
		+	[[Category: Membrane protein]]
		+	[[Category: Proton channel]]
		+	[[Category: S31n]]
		+	[[Category: Viral protein]]

OCA at 06:29, 10 October 2018

OCA — Wed, 10 Oct 2018 06:29:04 GMT

←Older revision		Revision as of 06:29, 10 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mjh is ON HOLD	+	The entry 6mjh is ON HOLD until Sep 20 2020

	Authors:		Authors:

OCA: Protected "6mjh" [edit=sysop:move=sysop]

OCA — Wed, 26 Sep 2018 06:38:26 GMT

Protected "6mjh" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:38, 26 September 2018

OCA: New page: '''Unreleased structure''' The entry 6mjh is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 26 Sep 2018 06:38:24 GMT

New page: '''Unreleased structure''' The entry 6mjh is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6mjh is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]