6mjz - Revision history

OCA at 02:46, 11 April 2020

OCA — Sat, 11 Apr 2020 02:46:53 GMT

←Older revision		Revision as of 02:46, 11 April 2020
Line 3:		Line 3:
	<SX load='6mjz' size='340' side='right' viewer='molstar' caption='[[6mjz]], [[Resolution\|resolution]] 4.30Å' scene=''>		<SX load='6mjz' size='340' side='right' viewer='molstar' caption='[[6mjz]], [[Resolution\|resolution]] 4.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mjz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpiv-3 Hpiv-3] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MJZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mjz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpiv-3 Hpiv-3] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MJZ FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">F, KMQ_34898gpF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11216 HPIV-3])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">F, KMQ_34898gpF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11216 HPIV-3])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjz OCA], [http://pdbe.org/6mjz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mjz RCSB], [http://www.ebi.ac.uk/pdbsum/6mjz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjz OCA], [http://pdbe.org/6mjz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mjz RCSB], [http://www.ebi.ac.uk/pdbsum/6mjz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:34, 6 March 2020

OCA — Fri, 06 Mar 2020 22:34:25 GMT

←Older revision		Revision as of 22:34, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174==		==Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174==
-	<~~StructureSection~~ load='6mjz' size='340' side='right'caption='[[6mjz]], [[Resolution\|resolution]] 4.30Å' scene=''>	+	<SX load='6mjz' size='340' side='right' viewer='molstar' caption='[[6mjz]], [[Resolution\|resolution]] 4.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mjz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpiv-3 Hpiv-3] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mjz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpiv-3 Hpiv-3] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJZ FirstGlance]. <br>
Line 19:		Line 19:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Hpiv-3]]		[[Category: Hpiv-3]]
	[[Category: Human]]		[[Category: Human]]

OCA at 10:58, 18 December 2019

OCA — Wed, 18 Dec 2019 10:58:35 GMT

←Older revision		Revision as of 10:58, 18 December 2019
Line 1:		Line 1:

	==Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174==		==Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174==
-	<StructureSection load='6mjz' size='340' side='right' caption='[[6mjz]], [[Resolution\|resolution]] 4.30Å' scene=''>	+	<StructureSection load='6mjz' size='340' side='right'caption='[[6mjz]], [[Resolution\|resolution]] 4.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mjz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpiv-3 Hpiv-3] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mjz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpiv-3 Hpiv-3] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJZ FirstGlance]. <br>
Line 22:		Line 22:
	[[Category: Hpiv-3]]		[[Category: Hpiv-3]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Acharya, P]]		[[Category: Acharya, P]]
	[[Category: Carragher, B]]		[[Category: Carragher, B]]

OCA at 21:11, 2 December 2018

OCA — Sun, 02 Dec 2018 21:11:41 GMT

←Older revision		Revision as of 21:11, 2 December 2018
Line 3:		Line 3:
	<StructureSection load='6mjz' size='340' side='right' caption='[[6mjz]], [[Resolution\|resolution]] 4.30Å' scene=''>		<StructureSection load='6mjz' size='340' side='right' caption='[[6mjz]], [[Resolution\|resolution]] 4.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mjz]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mjz]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hpiv-3 Hpiv-3] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjz OCA], [http://pdbe.org/6mjz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mjz RCSB], [http://www.ebi.ac.uk/pdbsum/6mjz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjz ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">F, KMQ_34898gpF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11216 HPIV-3])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjz OCA], [http://pdbe.org/6mjz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mjz RCSB], [http://www.ebi.ac.uk/pdbsum/6mjz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjz ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Parainfluenza virus types 1-4 (PIV1-4) are highly infectious human pathogens, of which PIV3 is most commonly responsible for severe respiratory illness in newborns, elderly, and immunocompromised individuals. To obtain a vaccine effective against all four PIV types, we engineered mutations in each of the four PIV fusion (F) glycoproteins to stabilize their metastable prefusion states, as such stabilization had previously enabled the elicitation of high-titer neutralizing antibodies against the related respiratory syncytial virus. A cryoelectron microscopy structure of an engineered PIV3 F prefusion-stabilized trimer, bound to the prefusion-specific antibody PIA174, revealed atomic-level details for how introduced mutations improved stability as well as how a single PIA174 antibody recognized the trimeric apex of prefusion PIV3 F. Nine combinations of six newly identified disulfides and two cavity-filling mutations stabilized the prefusion PIV3 F immunogens and induced 200- to 500-fold higher neutralizing titers in mice than were elicited by PIV3 F in the postfusion conformation. For PIV1, PIV2, and PIV4, we also obtained stabilized prefusion Fs, for which prefusion versus postfusion titers were 2- to 20-fold higher. Elicited murine responses were PIV type-specific, with little cross-neutralization of other PIVs. In nonhuman primates (NHPs), quadrivalent immunization with prefusion-stabilized Fs from PIV1-4 consistently induced potent neutralizing responses against all four PIVs. For PIV3, the average elicited NHP titer from the quadrivalent immunization was more than fivefold higher than any titer observed in a cohort of over 100 human adults, highlighting the ability of a prefusion-stabilized immunogen to elicit especially potent neutralization.
		+
		+	Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4.,Stewart-Jones GBE, Chuang GY, Xu K, Zhou T, Acharya P, Tsybovsky Y, Ou L, Zhang B, Fernandez-Rodriguez B, Gilardi V, Silacci-Fregni C, Beltramello M, Baxa U, Druz A, Kong WP, Thomas PV, Yang Y, Foulds KE, Todd JP, Wei H, Salazar AM, Scorpio DG, Carragher B, Potter CS, Corti D, Mascola JR, Lanzavecchia A, Kwong PD Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12265-12270. doi:, 10.1073/pnas.1811980115. Epub 2018 Nov 12. PMID:30420505<ref>PMID:30420505</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6mjz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hpiv-3]]
		+	[[Category: Human]]
	[[Category: Acharya, P]]		[[Category: Acharya, P]]
	[[Category: Carragher, B]]		[[Category: Carragher, B]]

OCA at 08:23, 14 November 2018

OCA — Wed, 14 Nov 2018 08:23:47 GMT

←Older revision		Revision as of 08:23, 14 November 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6mjz ~~is ON HOLD until Paper Publication~~	+	==Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174==
-		+	<StructureSection load='6mjz' size='340' side='right' caption='[[6mjz]], [[Resolution\|resolution]] 4.30Å' scene=''>
-	~~Authors~~: ~~Acharya, P~~., ~~Stewart~~-~~Jones~~, G., ~~Carragher, B~~., ~~Potter, C~~.S., ~~Kwong, P~~.D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6mjz]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJZ FirstGlance]. <br>
-	~~Description: Cryo-EM structure of Human Parainfluenza Viruses Types 3 (hPIV3) in complex with antibody PIA174~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjz OCA], [http://pdbe.org/6mjz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mjz RCSB], [http://www.ebi.ac.uk/pdbsum/6mjz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Acharya, P]]
	[[Category: Carragher, B]]		[[Category: Carragher, B]]
-	[[Category: ~~Acharya~~, P]]	+	[[Category: Kwong, P D]]
-	[[Category: Potter, C.S]]	+	[[Category: Potter, C S]]
-	~~[[Category: Kwong, P.D~~]]	+
	[[Category: Stewart-Jones, G]]		[[Category: Stewart-Jones, G]]
		+	[[Category: Antibody]]
		+	[[Category: Asymmetric]]
		+	[[Category: Complex]]
		+	[[Category: Hpiv3 envelope]]
		+	[[Category: Viral protein]]
		+	[[Category: Viral protein-immune system complex]]

OCA at 05:25, 31 October 2018

OCA — Wed, 31 Oct 2018 05:25:59 GMT

←Older revision		Revision as of 05:25, 31 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mjz is ON HOLD	+	The entry 6mjz is ON HOLD until Paper Publication

	Authors: Acharya, P., Stewart-Jones, G., Carragher, B., Potter, C.S., Kwong, P.D.		Authors: Acharya, P., Stewart-Jones, G., Carragher, B., Potter, C.S., Kwong, P.D.
Line 7:		Line 7:
	Description: Cryo-EM structure of Human Parainfluenza Viruses Types 3 (hPIV3) in complex with antibody PIA174		Description: Cryo-EM structure of Human Parainfluenza Viruses Types 3 (hPIV3) in complex with antibody PIA174
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Potter, C.S]]
-	[[Category: Kwong, P.D]]
	[[Category: Carragher, B]]		[[Category: Carragher, B]]
	[[Category: Acharya, P]]		[[Category: Acharya, P]]
		+	[[Category: Potter, C.S]]
		+	[[Category: Kwong, P.D]]
	[[Category: Stewart-Jones, G]]		[[Category: Stewart-Jones, G]]

OCA at 06:31, 17 October 2018

OCA — Wed, 17 Oct 2018 06:31:00 GMT

←Older revision		Revision as of 06:31, 17 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mjz is ON HOLD ~~until sometime in the future~~	+	The entry 6mjz is ON HOLD

	Authors: Acharya, P., Stewart-Jones, G., Carragher, B., Potter, C.S., Kwong, P.D.		Authors: Acharya, P., Stewart-Jones, G., Carragher, B., Potter, C.S., Kwong, P.D.
Line 7:		Line 7:
	Description: Cryo-EM structure of Human Parainfluenza Viruses Types 3 (hPIV3) in complex with antibody PIA174		Description: Cryo-EM structure of Human Parainfluenza Viruses Types 3 (hPIV3) in complex with antibody PIA174
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Carragher, B]]
-	[[Category: Acharya, P]]
	[[Category: Potter, C.S]]		[[Category: Potter, C.S]]
	[[Category: Kwong, P.D]]		[[Category: Kwong, P.D]]
		+	[[Category: Carragher, B]]
		+	[[Category: Acharya, P]]
	[[Category: Stewart-Jones, G]]		[[Category: Stewart-Jones, G]]

OCA at 06:29, 10 October 2018

OCA — Wed, 10 Oct 2018 06:29:08 GMT

←Older revision		Revision as of 06:29, 10 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mjz is ON HOLD	+	The entry 6mjz is ON HOLD until sometime in the future

	Authors: Acharya, P., Stewart-Jones, G., Carragher, B., Potter, C.S., Kwong, P.D.		Authors: Acharya, P., Stewart-Jones, G., Carragher, B., Potter, C.S., Kwong, P.D.
Line 7:		Line 7:
	Description: Cryo-EM structure of Human Parainfluenza Viruses Types 3 (hPIV3) in complex with antibody PIA174		Description: Cryo-EM structure of Human Parainfluenza Viruses Types 3 (hPIV3) in complex with antibody PIA174
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Potter, C.S]]
-	[[Category: Kwong, P.D]]
	[[Category: Carragher, B]]		[[Category: Carragher, B]]
	[[Category: Acharya, P]]		[[Category: Acharya, P]]
		+	[[Category: Potter, C.S]]
		+	[[Category: Kwong, P.D]]
	[[Category: Stewart-Jones, G]]		[[Category: Stewart-Jones, G]]

OCA: Protected "6mjz" [edit=sysop:move=sysop]

OCA — Wed, 03 Oct 2018 06:27:25 GMT

Protected "6mjz" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:27, 3 October 2018

OCA: New page: '''Unreleased structure''' The entry 6mjz is ON HOLD Authors: Acharya, P., Stewart-Jones, G., Carragher, B., Potter, C.S., Kwong, P.D. Description: Cryo-EM structure of Human Parainflu...

OCA — Wed, 03 Oct 2018 06:27:24 GMT

New page: '''Unreleased structure''' The entry 6mjz is ON HOLD Authors: Acharya, P., Stewart-Jones, G., Carragher, B., Potter, C.S., Kwong, P.D. Description: Cryo-EM structure of Human Parainflu...

New page

'''Unreleased structure'''

The entry 6mjz is ON HOLD

Authors: Acharya, P., Stewart-Jones, G., Carragher, B., Potter, C.S., Kwong, P.D.

Description: Cryo-EM structure of Human Parainfluenza Viruses Types 3 (hPIV3) in complex with antibody PIA174
[[Category: Unreleased Structures]]
[[Category: Potter, C.S]]
[[Category: Kwong, P.D]]
[[Category: Carragher, B]]
[[Category: Acharya, P]]
[[Category: Stewart-Jones, G]]