6mlu - Revision history

OCA at 02:48, 11 April 2020

OCA — Sat, 11 Apr 2020 02:48:04 GMT

←Older revision		Revision as of 02:48, 11 April 2020
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	<SX load='6mlu' size='340' side='right' viewer='molstar' caption='[[6mlu]], [[Resolution\|resolution]] 4.00Å' scene=''>		<SX load='6mlu' size='340' side='right' viewer='molstar' caption='[[6mlu]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MLU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MLU FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Seipin, CG9904 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Seipin, CG9904 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlu OCA], [http://pdbe.org/6mlu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mlu RCSB], [http://www.ebi.ac.uk/pdbsum/6mlu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlu OCA], [http://pdbe.org/6mlu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mlu RCSB], [http://www.ebi.ac.uk/pdbsum/6mlu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 22:34, 6 March 2020

OCA — Fri, 06 Mar 2020 22:34:52 GMT

←Older revision		Revision as of 22:34, 6 March 2020
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	==Cryo-EM structure of lipid droplet formation protein Seipin/BSCL2==		==Cryo-EM structure of lipid droplet formation protein Seipin/BSCL2==
-	<~~StructureSection~~ load='6mlu' size='340' side='right'caption='[[6mlu]], [[Resolution\|resolution]] 4.00Å' scene=''>	+	<SX load='6mlu' size='340' side='right' viewer='molstar' caption='[[6mlu]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLU FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Drome]]		[[Category: Drome]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 17:32, 20 November 2019

OCA — Wed, 20 Nov 2019 17:32:28 GMT

←Older revision		Revision as of 17:32, 20 November 2019
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	==Cryo-EM structure of lipid droplet formation protein Seipin/BSCL2==		==Cryo-EM structure of lipid droplet formation protein Seipin/BSCL2==
-	<StructureSection load='6mlu' size='340' side='right' caption='[[6mlu]], [[Resolution\|resolution]] 4.00Å' scene=''>	+	<StructureSection load='6mlu' size='340' side='right'caption='[[6mlu]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLU FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Arlt, H]]		[[Category: Arlt, H]]
	[[Category: Farese, V R]]		[[Category: Farese, V R]]

OCA at 07:21, 31 October 2018

OCA — Wed, 31 Oct 2018 07:21:53 GMT

←Older revision		Revision as of 07:21, 31 October 2018
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	<StructureSection load='6mlu' size='340' side='right' caption='[[6mlu]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='6mlu' size='340' side='right' caption='[[6mlu]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mlu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mlu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlu OCA], [http://pdbe.org/6mlu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mlu RCSB], [http://www.ebi.ac.uk/pdbsum/6mlu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlu ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Seipin, CG9904 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlu OCA], [http://pdbe.org/6mlu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mlu RCSB], [http://www.ebi.ac.uk/pdbsum/6mlu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BSCL2_DROME BSCL2_DROME]] Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis.[UniProtKB:Q9Z2E9]<ref>PMID:21533227</ref>		[[http://www.uniprot.org/uniprot/BSCL2_DROME BSCL2_DROME]] Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis.[UniProtKB:Q9Z2E9]<ref>PMID:21533227</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Metabolic energy is stored in cells primarily as triacylglycerols in lipid droplets (LDs), and LD dysregulation leads to metabolic diseases. The formation of monolayer-bound LDs from the endoplasmic reticulum (ER) bilayer is poorly understood, but the ER protein seipin is essential to this process. In this study, we report a cryo-electron microscopy structure and functional characterization of Drosophila melanogaster seipin. The structure reveals a ring-shaped dodecamer with the luminal domain of each monomer resolved at approximately 4.0 A. Each luminal domain monomer exhibits two distinctive features: a hydrophobic helix (HH) positioned toward the ER bilayer and a beta-sandwich domain with structural similarity to lipid-binding proteins. This structure and our functional testing in cells suggest a model in which seipin oligomers initially detect forming LDs in the ER via HHs and subsequently act as membrane anchors to enable lipid transfer and LD growth.
		+
		+	Cryo-electron microscopy structure of the lipid droplet-formation protein seipin.,Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV Jr, Walther TC J Cell Biol. 2018 Oct 16. pii: jcb.201809067. doi: 10.1083/jcb.201809067. PMID:30327422<ref>PMID:30327422</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6mlu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
	[[Category: Arlt, H]]		[[Category: Arlt, H]]
	[[Category: Farese, V R]]		[[Category: Farese, V R]]

OCA at 08:14, 17 October 2018

OCA — Wed, 17 Oct 2018 08:14:09 GMT

←Older revision		Revision as of 08:14, 17 October 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6mlu ~~is ON HOLD~~	+	==Cryo-EM structure of lipid droplet formation protein Seipin/BSCL2==
-		+	<StructureSection load='6mlu' size='340' side='right' caption='[[6mlu]], [[Resolution\|resolution]] 4.00Å' scene=''>
-	~~Authors~~: ~~Sui~~, X., ~~Arlt, H~~., ~~Liao, M~~., ~~Walther, C~~.W., ~~Farese, V~~.R.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6mlu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLU FirstGlance]. <br>
-	~~Description~~: ~~Cryo-EM structure~~ of lipid droplet formation ~~protein Seipin~~/~~BSCL2~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlu OCA], [http://pdbe.org/6mlu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mlu RCSB], [http://www.ebi.ac.uk/pdbsum/6mlu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlu ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BSCL2_DROME BSCL2_DROME]] Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis.[UniProtKB:Q9Z2E9]<ref>PMID:21533227</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arlt, H]]
		+	[[Category: Farese, V R]]
		+	[[Category: Liao, M]]
	[[Category: Sui, X]]		[[Category: Sui, X]]
-	[[Category: Walther, C.W]]	+	[[Category: Walther, C T]]
-	[[Category: ~~Liao, M~~]]	+	[[Category: Lipid droplet formation]]
-	[[Category: ~~Farese, V.R~~]]	+	[[Category: Lipid storage]]
-	[[Category: ~~Arlt, H~~]]	+	[[Category: Lipodystrophy]]
		+	[[Category: Membrane protein]]

OCA: Protected "6mlu" [edit=sysop:move=sysop]

OCA — Wed, 10 Oct 2018 06:30:07 GMT

Protected "6mlu" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:30, 10 October 2018

OCA: New page: '''Unreleased structure''' The entry 6mlu is ON HOLD Authors: Sui, X., Arlt, H., Liao, M., Walther, C.W., Farese, V.R. Description: Cryo-EM structure of lipid droplet formation protein...

OCA — Wed, 10 Oct 2018 06:30:05 GMT

New page: '''Unreleased structure''' The entry 6mlu is ON HOLD Authors: Sui, X., Arlt, H., Liao, M., Walther, C.W., Farese, V.R. Description: Cryo-EM structure of lipid droplet formation protein...

New page

'''Unreleased structure'''

The entry 6mlu is ON HOLD

Authors: Sui, X., Arlt, H., Liao, M., Walther, C.W., Farese, V.R.

Description: Cryo-EM structure of lipid droplet formation protein Seipin/BSCL2
[[Category: Unreleased Structures]]
[[Category: Sui, X]]
[[Category: Walther, C.W]]
[[Category: Liao, M]]
[[Category: Farese, V.R]]
[[Category: Arlt, H]]