6mlx - Revision history

OCA at 14:44, 13 March 2024

OCA — Wed, 13 Mar 2024 14:44:01 GMT

←Older revision		Revision as of 14:44, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='6mlx' size='340' side='right'caption='[[6mlx]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6mlx' size='340' side='right'caption='[[6mlx]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mlx]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"microspironema_pallidum"_(schaudinn_and_hoffmann_1905)_stiles_and_pfender_1905 "microspironema~~ pallidum~~" (schaudinn and hoffmann 1905) stiles and pfender 1905~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mlx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Treponema_pallidum Treponema pallidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MLX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlx OCA], [~~http~~://pdbe.org/6mlx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mlx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mlx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlx ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlx OCA], [https://pdbe.org/6mlx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mlx RCSB], [https://www.ebi.ac.uk/pdbsum/6mlx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlx ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/O06686_TREPL O06686_TREPL]
-	The phylogenetically divergent spirochete bacterium Treponema pallidum subsp. pallidum is the causative agent of syphilis. Central to the capacity of T. pallidum to establish infection is the ability of the pathogen to attach to a diversity of host cells. Many pathogenic bacteria employ leucine-rich repeat (LRR) domain-containing proteins to mediate protein-protein interactions, including attachment to host components and establishment of infection. Intriguingly, T. pallidum expresses only one putative LRR domain-containing protein (Tp0225) with an unknown function. In an effort to ascribe a function to Tp0225, a comprehensive phylogenetic analysis was first performed; this investigation revealed that Tp0225 clusters with the pathogenic clade of treponemes. Its crystal structure was then determined to 2.0 A resolution using Pt SAD phasing, which revealed a noncanonical architecture containing a hexameric LRR core with a discontinuous beta-sheet bridged by solvent molecules. Furthermore, a surface-exposed, hydrophobic pocket, which was found in Tp0225 but is largely absent in canonical LRR domains from other pathogenic bacteria, may serve to coordinate a hydrophobic ligand. Overall, this study provides the first structural characterization of the sole LRR domain-containing protein from T. pallidum and offers insight into the unique molecular landscape of this important human pathogen.	+
-		+
-	Structural characterization of Treponema pallidum Tp0225 reveals an unexpected leucine-rich repeat architecture.,Ramaswamy R, Houston S, Loveless B, Cameron CE, Boulanger MJ Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):~~489-495. doi:, 10.1107~~/~~S2053230X19007726. Epub 2019 Jun 26. PMID:31282868<ref>PMID:31282868<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 6mlx" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boulanger~~, M J~~]]	+	[[Category: Treponema pallidum]]
-	[[Category: Cameron~~, C E~~]]	+	[[Category: Boulanger MJ]]
-	[[Category: Houston, S]]	+	[[Category: Cameron CE]]
-	[[Category: Loveless~~, B C~~]]	+	[[Category: Houston S]]
-	[[Category: Ramaswamy, R]]	+	[[Category: Loveless BC]]
-	~~[[Category: Periplasmic lrr]]~~	+	[[Category: Ramaswamy R]]
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: T. pallidum]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 08:38, 24 July 2019

OCA — Wed, 24 Jul 2019 08:38:12 GMT

←Older revision		Revision as of 08:38, 24 July 2019
Line 3:		Line 3:
	<StructureSection load='6mlx' size='340' side='right'caption='[[6mlx]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6mlx' size='340' side='right'caption='[[6mlx]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mlx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mlx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"microspironema_pallidum"_(schaudinn_and_hoffmann_1905)_stiles_and_pfender_1905 "microspironema pallidum" (schaudinn and hoffmann 1905) stiles and pfender 1905]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLX FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlx OCA], [http://pdbe.org/6mlx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mlx RCSB], [http://www.ebi.ac.uk/pdbsum/6mlx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlx ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlx OCA], [http://pdbe.org/6mlx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mlx RCSB], [http://www.ebi.ac.uk/pdbsum/6mlx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlx ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The phylogenetically divergent spirochete bacterium Treponema pallidum subsp. pallidum is the causative agent of syphilis. Central to the capacity of T. pallidum to establish infection is the ability of the pathogen to attach to a diversity of host cells. Many pathogenic bacteria employ leucine-rich repeat (LRR) domain-containing proteins to mediate protein-protein interactions, including attachment to host components and establishment of infection. Intriguingly, T. pallidum expresses only one putative LRR domain-containing protein (Tp0225) with an unknown function. In an effort to ascribe a function to Tp0225, a comprehensive phylogenetic analysis was first performed; this investigation revealed that Tp0225 clusters with the pathogenic clade of treponemes. Its crystal structure was then determined to 2.0 A resolution using Pt SAD phasing, which revealed a noncanonical architecture containing a hexameric LRR core with a discontinuous beta-sheet bridged by solvent molecules. Furthermore, a surface-exposed, hydrophobic pocket, which was found in Tp0225 but is largely absent in canonical LRR domains from other pathogenic bacteria, may serve to coordinate a hydrophobic ligand. Overall, this study provides the first structural characterization of the sole LRR domain-containing protein from T. pallidum and offers insight into the unique molecular landscape of this important human pathogen.
		+
		+	Structural characterization of Treponema pallidum Tp0225 reveals an unexpected leucine-rich repeat architecture.,Ramaswamy R, Houston S, Loveless B, Cameron CE, Boulanger MJ Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):489-495. doi:, 10.1107/S2053230X19007726. Epub 2019 Jun 26. PMID:31282868<ref>PMID:31282868</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6mlx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:44, 17 July 2019

OCA — Wed, 17 Jul 2019 10:44:23 GMT

←Older revision		Revision as of 10:44, 17 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6mlx is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of T. pallidum Leucine Rich Repeat protein (TpLRR)==
-		+	<StructureSection load='6mlx' size='340' side='right'caption='[[6mlx]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6mlx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MLX FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlx OCA], [http://pdbe.org/6mlx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mlx RCSB], [http://www.ebi.ac.uk/pdbsum/6mlx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlx ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Boulanger, M J]]
		+	[[Category: Cameron, C E]]
		+	[[Category: Houston, S]]
		+	[[Category: Loveless, B C]]
		+	[[Category: Ramaswamy, R]]
		+	[[Category: Periplasmic lrr]]
		+	[[Category: Secreted]]
		+	[[Category: T. pallidum]]
		+	[[Category: Unknown function]]

OCA at 06:23, 30 January 2019

OCA — Wed, 30 Jan 2019 06:23:55 GMT

←Older revision		Revision as of 06:23, 30 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mlx is ON HOLD	+	The entry 6mlx is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6mlx" [edit=sysop:move=sysop]

OCA — Wed, 10 Oct 2018 06:30:29 GMT

Protected "6mlx" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:30, 10 October 2018

OCA: New page: '''Unreleased structure''' The entry 6mlx is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 10 Oct 2018 06:30:27 GMT

New page: '''Unreleased structure''' The entry 6mlx is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6mlx is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]