6mpw - Revision history

OCA at 06:36, 11 October 2023

OCA — Wed, 11 Oct 2023 06:36:28 GMT

←Older revision		Revision as of 06:36, 11 October 2023
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	<StructureSection load='6mpw' size='340' side='right'caption='[[6mpw]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6mpw' size='340' side='right'caption='[[6mpw]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mpw]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MPW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MPW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mpw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MPW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mpw OCA], [~~http~~://pdbe.org/6mpw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mpw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mpw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mpw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mpw OCA], [https://pdbe.org/6mpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mpw RCSB], [https://www.ebi.ac.uk/pdbsum/6mpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mpw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~DeGrado, W F~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Liu, L~~]]	+	[[Category: DeGrado WF]]
-	[[Category: ~~Mravic, M~~]]	+	[[Category: Liu L]]
-	[[Category: ~~De novo design]]~~	+	[[Category: Mravic M]]
-	~~[[Category: De novo protein]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Pentameric bundle~~]]	+

OCA at 07:01, 17 April 2019

OCA — Wed, 17 Apr 2019 07:01:40 GMT

←Older revision		Revision as of 07:01, 17 April 2019
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mpw OCA], [http://pdbe.org/6mpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mpw RCSB], [http://www.ebi.ac.uk/pdbsum/6mpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mpw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mpw OCA], [http://pdbe.org/6mpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mpw RCSB], [http://www.ebi.ac.uk/pdbsum/6mpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mpw ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The features that stabilize the structures of membrane proteins remain poorly understood. Polar interactions contribute modestly, and the hydrophobic effect contributes little to the energetics of apolar side-chain packing in membranes. Disruption of steric packing can destabilize the native folds of membrane proteins, but is packing alone sufficient to drive folding in lipids? If so, then membrane proteins stabilized by this feature should be readily designed and structurally characterized-yet this has not been achieved. Through simulation of the natural protein phospholamban and redesign of variants, we define a steric packing code underlying its assembly. Synthetic membrane proteins designed using this code and stabilized entirely by apolar side chains conform to the intended fold. Although highly stable, the steric complementarity required for their folding is surprisingly stringent. Structural informatics shows that the designed packing motif recurs across the proteome, emphasizing a prominent role for precise apolar packing in membrane protein folding, stabilization, and evolution.
		+
		+	Packing of apolar side chains enables accurate design of highly stable membrane proteins.,Mravic M, Thomaston JL, Tucker M, Solomon PE, Liu L, DeGrado WF Science. 2019 Mar 29;363(6434):1418-1423. doi: 10.1126/science.aav7541. PMID:30923216<ref>PMID:30923216</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6mpw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:07, 3 April 2019

OCA — Wed, 03 Apr 2019 07:07:14 GMT

←Older revision		Revision as of 07:07, 3 April 2019
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-	'''Unreleased structure'''

-	~~The entry 6mpw is ON HOLD until Paper Publication~~	+	==De Novo Design of membrane protein--mini-eVgL membrane protein, C2221 form-1==
-		+	<StructureSection load='6mpw' size='340' side='right'caption='[[6mpw]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors: Mravic, M., Liu, L., DeGrado, W.F.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6mpw]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MPW FirstGlance]. <br>
-	~~Description:~~ De Novo Design of membrane protein--mini-eVgL membrane protein, C2221 form-1	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mpw OCA], [http://pdbe.org/6mpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mpw RCSB], [http://www.ebi.ac.uk/pdbsum/6mpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mpw ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: DeGrado, W F]]
	[[Category: Liu, L]]		[[Category: Liu, L]]
-	[[Category: Degrado, W.F]]
	[[Category: Mravic, M]]		[[Category: Mravic, M]]
		+	[[Category: De novo design]]
		+	[[Category: De novo protein]]
		+	[[Category: Membrane protein]]
		+	[[Category: Pentameric bundle]]

OCA at 04:30, 24 October 2018

OCA — Wed, 24 Oct 2018 04:30:25 GMT

←Older revision		Revision as of 04:30, 24 October 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mpw is ON HOLD	+	The entry 6mpw is ON HOLD until Paper Publication

	Authors: Mravic, M., Liu, L., DeGrado, W.F.		Authors: Mravic, M., Liu, L., DeGrado, W.F.

OCA: Protected "6mpw" [edit=sysop:move=sysop]

OCA — Wed, 17 Oct 2018 06:37:47 GMT

Protected "6mpw" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:37, 17 October 2018

OCA: New page: '''Unreleased structure''' The entry 6mpw is ON HOLD Authors: Mravic, M., Liu, L., DeGrado, W.F. Description: De Novo Design of membrane protein--mini-eVgL membrane protein, C2221 form...

OCA — Wed, 17 Oct 2018 06:37:45 GMT

New page: '''Unreleased structure''' The entry 6mpw is ON HOLD Authors: Mravic, M., Liu, L., DeGrado, W.F. Description: De Novo Design of membrane protein--mini-eVgL membrane protein, C2221 form...

New page

'''Unreleased structure'''

The entry 6mpw is ON HOLD

Authors: Mravic, M., Liu, L., DeGrado, W.F.

Description: De Novo Design of membrane protein--mini-eVgL membrane protein, C2221 form-1
[[Category: Unreleased Structures]]
[[Category: Liu, L]]
[[Category: Degrado, W.F]]
[[Category: Mravic, M]]