6mpz - Revision history

OCA at 10:32, 18 March 2021

OCA — Thu, 18 Mar 2021 10:32:29 GMT

←Older revision		Revision as of 10:32, 18 March 2021
Line 3:		Line 3:
	<StructureSection load='6mpz' size='340' side='right'caption='[[6mpz]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6mpz' size='340' side='right'caption='[[6mpz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mpz]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lachnospiraceae_bacterium_c6a11 Lachnospiraceae bacterium c6a11] and [~~http~~://en.wikipedia.org/wiki/Promm Promm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MPZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MPZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mpz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Lachnospiraceae_bacterium_c6a11 Lachnospiraceae bacterium c6a11] and [https://en.wikipedia.org/wiki/Promm Promm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MPZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16P:3,6,9,12,15,18-HEXAOXAICOSANE'>16P</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16P:3,6,9,12,15,18-HEXAOXAICOSANE'>16P</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLZ:AMINO-ACETALDEHYDE'>GLZ</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLZ:AMINO-ACETALDEHYDE'>GLZ</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mpz OCA], [~~http~~://pdbe.org/6mpz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mpz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mpz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mpz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mpz OCA], [https://pdbe.org/6mpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mpz RCSB], [https://www.ebi.ac.uk/pdbsum/6mpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mpz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:27, 1 January 2020

OCA — Wed, 01 Jan 2020 11:27:06 GMT

←Older revision		Revision as of 11:27, 1 January 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6mpz is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of a double glycine motif protease from AMS/PCAT transporter in complex with the leader peptide==
		+	<StructureSection load='6mpz' size='340' side='right'caption='[[6mpz]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6mpz]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lachnospiraceae_bacterium_c6a11 Lachnospiraceae bacterium c6a11] and [http://en.wikipedia.org/wiki/Promm Promm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MPZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16P:3,6,9,12,15,18-HEXAOXAICOSANE'>16P</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLZ:AMINO-ACETALDEHYDE'>GLZ</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mpz OCA], [http://pdbe.org/6mpz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mpz RCSB], [http://www.ebi.ac.uk/pdbsum/6mpz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mpz ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The secretion of peptides and proteins is essential for survival and ecological adaptation of bacteria. Dual-functional ATP-binding cassette transporters export antimicrobial or quorum signaling peptides in Gram-positive bacteria. Their substrates contain a leader sequence that is excised by an N-terminal peptidase C39 domain at a double Gly motif. We characterized the protease domain (LahT150) of a transporter from a lanthipeptide biosynthetic operon in Lachnospiraceae and demonstrate that this protease can remove the leader peptide from a diverse set of peptides. The 2.0 A resolution crystal structure of the protease domain in complex with a covalently bound leader peptide demonstrates the basis for substrate recognition across the entire class of such transporters. The structural data also provide a model for understanding the role of leader peptide recognition in the translocation cycle, and the function of degenerate, non-functional C39-like domains (CLD) in substrate recruitment in toxin exporters in Gram-negative bacteria.

-	~~Authors:~~ Dong, S.-H., Nair, S.K.	+	Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease.,Bobeica SC, Dong SH, Huo L, Mazo N, McLaughlin MI, Jimenez-Oses G, Nair SK, van der Donk WA Elife. 2019 Jan 14;8. pii: 42305. doi: 10.7554/eLife.42305. PMID:30638446<ref>PMID:30638446</ref>

-	~~Description: Crystal structure of a double glycine motif protease from AMS~~/~~PCAT transporter in complex with~~ the ~~leader peptide~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: ~~Nair, S.K~~]]	+	<div class="pdbe-citations 6mpz" style="background-color:#fffaf0;"></div>
-	[[Category: Dong, S.-H]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lachnospiraceae bacterium c6a11]]
		+	[[Category: Large Structures]]
		+	[[Category: Promm]]
		+	[[Category: Dong, S H]]
		+	[[Category: Nair, S K]]
		+	[[Category: Lantibiotic]]
		+	[[Category: Leader peptide]]
		+	[[Category: Peptidase c39 domain]]
		+	[[Category: Peptide secretion]]
		+	[[Category: Transport protein]]

OCA at 05:28, 31 October 2018

OCA — Wed, 31 Oct 2018 05:28:18 GMT

←Older revision		Revision as of 05:28, 31 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mpz is ON HOLD	+	The entry 6mpz is ON HOLD until Paper Publication

	Authors: Dong, S.-H., Nair, S.K.		Authors: Dong, S.-H., Nair, S.K.

OCA: Protected "6mpz" [edit=sysop:move=sysop]

OCA — Wed, 17 Oct 2018 06:38:03 GMT

Protected "6mpz" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:38, 17 October 2018

OCA: New page: '''Unreleased structure''' The entry 6mpz is ON HOLD Authors: Dong, S.-H., Nair, S.K. Description: Crystal structure of a double glycine motif protease from AMS/PCAT transporter in com...

OCA — Wed, 17 Oct 2018 06:38:02 GMT

New page: '''Unreleased structure''' The entry 6mpz is ON HOLD Authors: Dong, S.-H., Nair, S.K. Description: Crystal structure of a double glycine motif protease from AMS/PCAT transporter in com...

New page

'''Unreleased structure'''

The entry 6mpz is ON HOLD

Authors: Dong, S.-H., Nair, S.K.

Description: Crystal structure of a double glycine motif protease from AMS/PCAT transporter in complex with the leader peptide
[[Category: Unreleased Structures]]
[[Category: Nair, S.K]]
[[Category: Dong, S.-H]]