6mqb - Revision history

OCA at 06:36, 11 October 2023

OCA — Wed, 11 Oct 2023 06:36:41 GMT

←Older revision		Revision as of 06:36, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6mqb' size='340' side='right'caption='[[6mqb]], [[Resolution\|resolution]] 2.12Å' scene=''>		<StructureSection load='6mqb' size='340' side='right'caption='[[6mqb]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mqb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MQB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mqb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MQB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID~~-~~GUANYLATE+ESTER'>GNP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.12Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SEPT12 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqb OCA], [https://pdbe.org/6mqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mqb RCSB], [https://www.ebi.ac.uk/pdbsum/6mqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqb OCA], [https://pdbe.org/6mqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mqb RCSB], [https://www.ebi.ac.uk/pdbsum/6mqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>	+	[https://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brandao-Neto, J]]	+	[[Category: Brandao-Neto J]]
-	[[Category: Castro~~, D K.S V~~]]	+	[[Category: Castro DKSV]]
-	[[Category: Garratt~~, R C~~]]	+	[[Category: Garratt RC]]
-	[[Category: Pereira~~, H M~~]]	+	[[Category: Pereira HM]]
-	[[Category: Ulian~~, A P.U]]~~	+	[[Category: Ulian APU]]
-	~~[[Category: Cytoskeleton component septin gtpase spermatogenesis]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 15:25, 8 June 2021

OCA — Tue, 08 Jun 2021 15:25:10 GMT

OCA at 06:34, 3 June 2020

OCA — Wed, 03 Jun 2020 06:34:48 GMT

←Older revision		Revision as of 06:34, 3 June 2020
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>		[[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human septins 3, 9 and 12 are the only members of a specific subgroup of septins that display several unusual features, including the absence of a C-terminal coiled coil. This particular subgroup (the SEPT3 septins) are present in rod-like octameric protofilaments but are lacking in similar hexameric assemblies, which only contain representatives of the three remaining subgroups. Both hexamers and octamers can self-assemble into mixed filaments by end-to-end association, implying that the SEPT3 septins may facilitate polymerization but not necessarily function. These filaments frequently associate into higher order complexes which associate with biological membranes, triggering a wide range of cellular events. In the present work, a complete compendium of crystal structures for the GTP-binding domains of all of the SEPT3 subgroup members when bound to either GDP or to a GTP analogue is provided. The structures reveal a unique degree of plasticity at one of the filamentous interfaces (dubbed NC). Specifically, structures of the GDP and GTPgammaS complexes of SEPT9 reveal a squeezing mechanism at the NC interface which would expel a polybasic region from its binding site and render it free to interact with negatively charged membranes. On the other hand, a polyacidic region associated with helix alpha5', the orientation of which is particular to this subgroup, provides a safe haven for the polybasic region when retracted within the interface. Together, these results suggest a mechanism which couples GTP binding and hydrolysis to membrane association and implies a unique role for the SEPT3 subgroup in this process. These observations can be accounted for by constellations of specific amino-acid residues that are found only in this subgroup and by the absence of the C-terminal coiled coil. Such conclusions can only be reached owing to the completeness of the structural studies presented here.
		+
		+	A complete compendium of crystal structures for the human SEPT3 subgroup reveals functional plasticity at a specific septin interface.,Castro DKSDV, da Silva SMO, Pereira HD, Macedo JNA, Leonardo DA, Valadares NF, Kumagai PS, Brandao-Neto J, Araujo APU, Garratt RC IUCrJ. 2020 Mar 28;7(Pt 3):462-479. doi: 10.1107/S2052252520002973. eCollection, 2020 May 1. PMID:32431830<ref>PMID:32431830</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6mqb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:18, 8 April 2020

OCA — Wed, 08 Apr 2020 07:18:55 GMT

←Older revision		Revision as of 07:18, 8 April 2020
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	<StructureSection load='6mqb' size='340' side='right'caption='[[6mqb]], [[Resolution\|resolution]] 2.12Å' scene=''>		<StructureSection load='6mqb' size='340' side='right'caption='[[6mqb]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MQB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MQB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SEPT12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SEPT12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqb OCA], [http://pdbe.org/6mqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqb RCSB], [http://www.ebi.ac.uk/pdbsum/6mqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqb OCA], [http://pdbe.org/6mqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqb RCSB], [http://www.ebi.ac.uk/pdbsum/6mqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 11:27, 1 January 2020

OCA — Wed, 01 Jan 2020 11:27:21 GMT

←Older revision		Revision as of 11:27, 1 January 2020
Line 3:		Line 3:
	<StructureSection load='6mqb' size='340' side='right'caption='[[6mqb]], [[Resolution\|resolution]] 2.12Å' scene=''>		<StructureSection load='6mqb' size='340' side='right'caption='[[6mqb]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mqb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SEPT12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqb OCA], [http://pdbe.org/6mqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqb RCSB], [http://www.ebi.ac.uk/pdbsum/6mqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqb OCA], [http://pdbe.org/6mqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqb RCSB], [http://www.ebi.ac.uk/pdbsum/6mqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqb ProSAT]</span></td></tr>
	</table>		</table>
Line 15:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Brandao-Neto, J]]		[[Category: Brandao-Neto, J]]

OCA at 05:56, 16 October 2019

OCA — Wed, 16 Oct 2019 05:56:00 GMT

←Older revision		Revision as of 05:56, 16 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6mqb ~~is ON HOLD until Oct 09 2020~~	+	==Crystal Structure of GTPase Domain of Human Septin 12 in complex with GMPPNP in Space Group C2221==
-		+	<StructureSection load='6mqb' size='340' side='right'caption='[[6mqb]], [[Resolution\|resolution]] 2.12Å' scene=''>
-	~~Authors~~: ~~Castro, D~~.K.S.V., ~~Pereira, H~~.M., ~~Brandao~~-~~Neto~~, J., ~~Ulian~~, A.P.U., ~~Garratt, R~~.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6mqb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQB FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of~~ GTPase ~~Domain of Human Septin 12~~ in ~~complex~~ with ~~GMPPNP~~ in ~~Space Group C2221~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqb OCA], [http://pdbe.org/6mqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqb RCSB], [http://www.ebi.ac.uk/pdbsum/6mqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqb ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Brandao-Neto, J]]		[[Category: Brandao-Neto, J]]
-	[[Category: ~~Garratt~~, R.C]]	+	[[Category: Castro, D K.S V]]
-	[[Category: ~~Pereira~~, ~~H.M~~]]	+	[[Category: Garratt, R C]]
-	[[Category: ~~Castro~~, ~~D.K.S.V~~]]	+	[[Category: Pereira, H M]]
-	[[Category: Ulian, A.P.U]]	+	[[Category: Ulian, A P.U]]
		+	[[Category: Cytoskeleton component septin gtpase spermatogenesis]]
		+	[[Category: Structural protein]]

OCA at 05:28, 31 October 2018

OCA — Wed, 31 Oct 2018 05:28:32 GMT

←Older revision		Revision as of 05:28, 31 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mqb is ON HOLD	+	The entry 6mqb is ON HOLD until Oct 09 2020

	Authors: Castro, D.K.S.V., Pereira, H.M., Brandao-Neto, J., Ulian, A.P.U., Garratt, R.C.		Authors: Castro, D.K.S.V., Pereira, H.M., Brandao-Neto, J., Ulian, A.P.U., Garratt, R.C.
Line 7:		Line 7:
	Description: Crystal Structure of GTPase Domain of Human Septin 12 in complex with GMPPNP in Space Group C2221		Description: Crystal Structure of GTPase Domain of Human Septin 12 in complex with GMPPNP in Space Group C2221
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Castro, D.K.S.V]]
	[[Category: Brandao-Neto, J]]		[[Category: Brandao-Neto, J]]
	[[Category: Garratt, R.C]]		[[Category: Garratt, R.C]]
	[[Category: Pereira, H.M]]		[[Category: Pereira, H.M]]
		+	[[Category: Castro, D.K.S.V]]
	[[Category: Ulian, A.P.U]]		[[Category: Ulian, A.P.U]]

OCA: Protected "6mqb" [edit=sysop:move=sysop]

OCA — Wed, 17 Oct 2018 06:39:02 GMT

Protected "6mqb" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:39, 17 October 2018

OCA: New page: '''Unreleased structure''' The entry 6mqb is ON HOLD Authors: Castro, D.K.S.V., Pereira, H.M., Brandao-Neto, J., Ulian, A.P.U., Garratt, R.C. Description: Crystal Structure of GTPase D...

OCA — Wed, 17 Oct 2018 06:39:00 GMT

New page: '''Unreleased structure''' The entry 6mqb is ON HOLD Authors: Castro, D.K.S.V., Pereira, H.M., Brandao-Neto, J., Ulian, A.P.U., Garratt, R.C. Description: Crystal Structure of GTPase D...

New page

'''Unreleased structure'''

The entry 6mqb is ON HOLD

Authors: Castro, D.K.S.V., Pereira, H.M., Brandao-Neto, J., Ulian, A.P.U., Garratt, R.C.

Description: Crystal Structure of GTPase Domain of Human Septin 12 in complex with GMPPNP in Space Group C2221
[[Category: Unreleased Structures]]
[[Category: Castro, D.K.S.V]]
[[Category: Brandao-Neto, J]]
[[Category: Garratt, R.C]]
[[Category: Pereira, H.M]]
[[Category: Ulian, A.P.U]]

←Older revision		Revision as of 15:25, 8 June 2021
Line 3:		Line 3:
	<StructureSection load='6mqb' size='340' side='right'caption='[[6mqb]], [[Resolution\|resolution]] 2.12Å' scene=''>		<StructureSection load='6mqb' size='340' side='right'caption='[[6mqb]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mqb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6MQB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mqb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MQB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SEPT12 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SEPT12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqb OCA], [~~http~~://pdbe.org/6mqb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mqb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mqb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqb OCA], [https://pdbe.org/6mqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mqb RCSB], [https://www.ebi.ac.uk/pdbsum/6mqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry.	+	[[https://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Non-syndromic male infertility due to sperm motility disorder. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>	+	[[https://www.uniprot.org/uniprot/SEP12_HUMAN SEP12_HUMAN]] Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential).<ref>PMID:24213608</ref> <ref>PMID:25588830</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==