6mqr - Revision history

OCA at 06:18, 7 August 2019

OCA — Wed, 07 Aug 2019 06:18:52 GMT

←Older revision		Revision as of 06:18, 7 August 2019
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	<StructureSection load='6mqr' size='340' side='right'caption='[[6mqr]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='6mqr' size='340' side='right'caption='[[6mqr]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mqr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mqr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/New_world_monkeys New world monkeys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqr OCA], [http://pdbe.org/6mqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqr RCSB], [http://www.ebi.ac.uk/pdbsum/6mqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqr OCA], [http://pdbe.org/6mqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqr RCSB], [http://www.ebi.ac.uk/pdbsum/6mqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqr ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The vaccine-mediated elicitation of antibodies (Abs) capable of neutralizing diverse HIV-1 strains has been a long-standing goal. To understand how broadly neutralizing antibodies (bNAbs) can be elicited, we identified, characterized, and tracked five neutralizing Ab lineages targeting the HIV-1-fusion peptide (FP) in vaccinated macaques over time. Genetic and structural analyses revealed two of these lineages to belong to a reproducible class capable of neutralizing up to 59% of 208 diverse viral strains. B cell analysis indicated each of the five lineages to have been initiated and expanded by FP-carrier priming, with envelope (Env)-trimer boosts inducing cross-reactive neutralization. These Abs had binding-energy hotspots focused on FP, whereas several FP-directed Abs induced by immunization with Env trimer-only were less FP-focused and less broadly neutralizing. Priming with a conserved subregion, such as FP, can thus induce Abs with binding-energy hotspots coincident with the target subregion and capable of broad neutralization.
		+
		+	Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.,Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schon A, Todd JP, Wang S, Wei H, Wu W, Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR Cell. 2019 Jul 25;178(3):567-584.e19. doi: 10.1016/j.cell.2019.06.030. PMID:31348886<ref>PMID:31348886</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6mqr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: New world monkeys]]
	[[Category: Kwong, P D]]		[[Category: Kwong, P D]]
	[[Category: Wang, Y]]		[[Category: Wang, Y]]

OCA at 06:21, 31 July 2019

OCA — Wed, 31 Jul 2019 06:21:25 GMT

←Older revision		Revision as of 06:21, 31 July 2019
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-	'''Unreleased structure'''

-	~~The entry 6mqr is ON HOLD until Paper Publication~~	+	==Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-a.01 in complex with FP (residue 512-519)==
-		+	<StructureSection load='6mqr' size='340' side='right'caption='[[6mqr]], [[Resolution\|resolution]] 2.45Å' scene=''>
-	~~Authors: Xu, K., Wang, Y., Kwong, P.D.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6mqr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQR FirstGlance]. <br>
-	~~Description:~~ Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-a.01 in complex with FP (residue 512-519)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqr OCA], [http://pdbe.org/6mqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqr RCSB], [http://www.ebi.ac.uk/pdbsum/6mqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqr ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kwong, P D]]
	[[Category: Wang, Y]]		[[Category: Wang, Y]]
-	[[Category: Kwong, P.D]]
	[[Category: Xu, K]]		[[Category: Xu, K]]
		+	[[Category: Fp]]
		+	[[Category: Fusion peptide]]
		+	[[Category: Hiv]]
		+	[[Category: Immune system]]
		+	[[Category: Neutralizing]]
		+	[[Category: Nhp]]
		+	[[Category: Vaccine]]

OCA at 05:28, 31 October 2018

OCA — Wed, 31 Oct 2018 05:28:50 GMT

←Older revision		Revision as of 05:28, 31 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mqr is ON HOLD	+	The entry 6mqr is ON HOLD until Paper Publication

	Authors: Xu, K., Wang, Y., Kwong, P.D.		Authors: Xu, K., Wang, Y., Kwong, P.D.
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	Description: Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-a.01 in complex with FP (residue 512-519)		Description: Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-a.01 in complex with FP (residue 512-519)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Wang, Y]]
	[[Category: Kwong, P.D]]		[[Category: Kwong, P.D]]
	[[Category: Xu, K]]		[[Category: Xu, K]]
-	[[Category: Wang, Y]]

OCA: Protected "6mqr" [edit=sysop:move=sysop]

OCA — Wed, 17 Oct 2018 06:40:12 GMT

Protected "6mqr" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:40, 17 October 2018

OCA: New page: '''Unreleased structure''' The entry 6mqr is ON HOLD Authors: Xu, K., Wang, Y., Kwong, P.D. Description: Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-a.01 in complex wit...

OCA — Wed, 17 Oct 2018 06:40:11 GMT

New page: '''Unreleased structure''' The entry 6mqr is ON HOLD Authors: Xu, K., Wang, Y., Kwong, P.D. Description: Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-a.01 in complex wit...

New page

'''Unreleased structure'''

The entry 6mqr is ON HOLD

Authors: Xu, K., Wang, Y., Kwong, P.D.

Description: Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-a.01 in complex with FP (residue 512-519)
[[Category: Unreleased Structures]]
[[Category: Kwong, P.D]]
[[Category: Xu, K]]
[[Category: Wang, Y]]