6mwc - Revision history

OCA at 02:58, 11 April 2020

OCA — Sat, 11 Apr 2020 02:58:49 GMT

←Older revision		Revision as of 02:58, 11 April 2020
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	<SX load='6mwc' size='340' side='right' viewer='molstar' caption='[[6mwc]], [[Resolution\|resolution]] 7.50Å' scene=''>		<SX load='6mwc' size='340' side='right' viewer='molstar' caption='[[6mwc]], [[Resolution\|resolution]] 7.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mwc]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Eeev Eeev] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MWC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MWC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mwc]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Eeev Eeev] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MWC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MWC FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mwc OCA], [http://pdbe.org/6mwc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mwc RCSB], [http://www.ebi.ac.uk/pdbsum/6mwc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mwc ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mwc OCA], [http://pdbe.org/6mwc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mwc RCSB], [http://www.ebi.ac.uk/pdbsum/6mwc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mwc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:37, 5 March 2020

OCA — Thu, 05 Mar 2020 04:37:55 GMT

←Older revision		Revision as of 04:37, 5 March 2020
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	==CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody==		==CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody==
-	<~~StructureSection~~ load='6mwc' size='340' side='right'caption='[[6mwc]], [[Resolution\|resolution]] 7.50Å' scene=''>	+	<SX load='6mwc' size='340' side='right' viewer='molstar' caption='[[6mwc]], [[Resolution\|resolution]] 7.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mwc]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Eeev Eeev] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MWC FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mwc]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Eeev Eeev] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MWC FirstGlance]. <br>
Line 21:		Line 21:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Eeev]]		[[Category: Eeev]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 11:13, 18 December 2019

OCA — Wed, 18 Dec 2019 11:13:10 GMT

←Older revision		Revision as of 11:13, 18 December 2019
Line 1:		Line 1:

	==CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody==		==CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody==
-	<StructureSection load='6mwc' size='340' side='right' caption='[[6mwc]], [[Resolution\|resolution]] 7.50Å' scene=''>	+	<StructureSection load='6mwc' size='340' side='right'caption='[[6mwc]], [[Resolution\|resolution]] 7.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6mwc]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Eeev Eeev] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MWC FirstGlance]. <br>		<table><tr><td colspan='2'>[[6mwc]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Eeev Eeev] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MWC FirstGlance]. <br>
Line 15:		Line 15:
	</div>		</div>
	<div class="pdbe-citations 6mwc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6mwc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Eeev]]		[[Category: Eeev]]
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Buda, G]]		[[Category: Buda, G]]

OCA at 08:47, 26 December 2018

OCA — Wed, 26 Dec 2018 08:47:11 GMT

←Older revision		Revision as of 08:47, 26 December 2018
Line 3:		Line 3:
	<StructureSection load='6mwc' size='340' side='right' caption='[[6mwc]], [[Resolution\|resolution]] 7.50Å' scene=''>		<StructureSection load='6mwc' size='340' side='right' caption='[[6mwc]], [[Resolution\|resolution]] 7.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mwc]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MWC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mwc]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Eeev Eeev] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MWC FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mwc OCA], [http://pdbe.org/6mwc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mwc RCSB], [http://www.ebi.ac.uk/pdbsum/6mwc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mwc ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mwc OCA], [http://pdbe.org/6mwc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mwc RCSB], [http://www.ebi.ac.uk/pdbsum/6mwc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mwc ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Alphaviruses are enveloped pathogens that cause arthritis and encephalitis. Here, we report a 4.4-A cryoelectron microscopy (cryo-EM) structure of eastern equine encephalitis virus (EEEV), an alphavirus that causes fatal encephalitis in humans. Our analysis provides insights into viral entry into host cells. The envelope protein E2 showed a binding site for the cellular attachment factor heparan sulfate. The presence of a cryptic E2 glycan suggests how EEEV escapes surveillance by lectin-expressing myeloid lineage cells, which are sentinels of the immune system. A mechanism for nucleocapsid core release and disassembly upon viral entry was inferred based on pH changes and capsid dissociation from envelope proteins. The EEEV capsid structure showed a viral RNA genome binding site adjacent to a ribosome binding site for viral genome translation following genome release. Using five Fab-EEEV complexes derived from neutralizing antibodies, our investigation provides insights into EEEV host cell interactions and protective epitopes relevant to vaccine design.
		+
		+	Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization.,Hasan SS, Sun C, Kim AS, Watanabe Y, Chen CL, Klose T, Buda G, Crispin M, Diamond MS, Klimstra WB, Rossmann MG Cell Rep. 2018 Dec 11;25(11):3136-3147.e5. doi: 10.1016/j.celrep.2018.11.067. PMID:30540945<ref>PMID:30540945</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6mwc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Eeev]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Buda, G]]		[[Category: Buda, G]]
Line 22:		Line 34:
	[[Category: Alphavirus]]		[[Category: Alphavirus]]
	[[Category: Eastern equine encephalitis virus]]		[[Category: Eastern equine encephalitis virus]]
-	[[Category: Eeev]]
	[[Category: Fab]]		[[Category: Fab]]
	[[Category: Sindbi]]		[[Category: Sindbi]]
	[[Category: Virus-immune system complex]]		[[Category: Virus-immune system complex]]

OCA at 08:34, 19 December 2018

OCA — Wed, 19 Dec 2018 08:34:42 GMT

←Older revision		Revision as of 08:34, 19 December 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6mwc ~~is ON HOLD~~	+	==CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody==
-		+	<StructureSection load='6mwc' size='340' side='right' caption='[[6mwc]], [[Resolution\|resolution]] 7.50Å' scene=''>
-	~~Authors~~: ~~Hasan, S~~.S.~~, Sun, C~~.~~, Kim, A~~.S.~~, Watanabe, Y~~.~~, Chen, C~~.L.~~, Klose, T~~., ~~Buda, G~~., ~~Crispin, M~~., ~~Diamond, M~~.S., ~~Klimstra, W~~.B., ~~Rossmann, M~~.G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6mwc]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MWC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MWC FirstGlance]. <br>
-	~~Description~~: ~~CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mwc OCA], [http://pdbe.org/6mwc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mwc RCSB], [http://www.ebi.ac.uk/pdbsum/6mwc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mwc ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Diamond~~, ~~M.S~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Mus musculus]]
		+	[[Category: Buda, G]]
		+	[[Category: Chen, C L]]
	[[Category: Crispin, M]]		[[Category: Crispin, M]]
		+	[[Category: Diamond, M S]]
		+	[[Category: Hasan, S S]]
		+	[[Category: Kim, A S]]
		+	[[Category: Klimstra, W B]]
		+	[[Category: Klose, T]]
		+	[[Category: Rossmann, M G]]
	[[Category: Sun, C]]		[[Category: Sun, C]]
-	[[Category: Klimstra, W.B]]
-	[[Category: Rossmann, M.G]]
-	[[Category: Hasan, S.S]]
-	[[Category: Klose, T]]
-	[[Category: Buda, G]]
-	[[Category: Kim, A.S]]
-	[[Category: Chen, C.L]]
	[[Category: Watanabe, Y]]		[[Category: Watanabe, Y]]
		+	[[Category: Alphavirus]]
		+	[[Category: Eastern equine encephalitis virus]]
		+	[[Category: Eeev]]
		+	[[Category: Fab]]
		+	[[Category: Sindbi]]
		+	[[Category: Virus-immune system complex]]

OCA: Protected "6mwc" [edit=sysop:move=sysop]

OCA — Wed, 07 Nov 2018 10:53:11 GMT

Protected "6mwc" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:53, 7 November 2018

OCA: New page: '''Unreleased structure''' The entry 6mwc is ON HOLD Authors: Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B.,...

OCA — Wed, 07 Nov 2018 10:53:10 GMT

New page: '''Unreleased structure''' The entry 6mwc is ON HOLD Authors: Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B.,...

New page

'''Unreleased structure'''

The entry 6mwc is ON HOLD

Authors: Hasan, S.S., Sun, C., Kim, A.S., Watanabe, Y., Chen, C.L., Klose, T., Buda, G., Crispin, M., Diamond, M.S., Klimstra, W.B., Rossmann, M.G.

Description: CryoEM structure of chimeric Eastern Equine Encephalitis Virus with Fab of EEEV-5 antibody
[[Category: Unreleased Structures]]
[[Category: Diamond, M.S]]
[[Category: Crispin, M]]
[[Category: Sun, C]]
[[Category: Klimstra, W.B]]
[[Category: Rossmann, M.G]]
[[Category: Hasan, S.S]]
[[Category: Klose, T]]
[[Category: Buda, G]]
[[Category: Kim, A.S]]
[[Category: Chen, C.L]]
[[Category: Watanabe, Y]]