6mxq - Revision history

OCA at 07:36, 1 May 2024

OCA — Wed, 01 May 2024 07:36:15 GMT

←Older revision		Revision as of 07:36, 1 May 2024
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	==Solution structure of a c-JUN 5' UTR stem-loop associated with specialized cap-dependent translation initiation==		==Solution structure of a c-JUN 5' UTR stem-loop associated with specialized cap-dependent translation initiation==
-	<StructureSection load='6mxq' size='340' side='right'caption='[[6mxq~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='6mxq' size='340' side='right'caption='[[6mxq]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mxq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MXQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6MXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mxq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MXQ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxq OCA], [~~http~~://pdbe.org/6mxq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mxq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mxq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxq ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxq OCA], [https://pdbe.org/6mxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mxq RCSB], [https://www.ebi.ac.uk/pdbsum/6mxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxq ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Specialized translation initiation is a novel form of regulation of protein synthesis, whereby RNA structures within the 5'-UTR regulate translation rates of specific mRNAs. Similar to internal ribosome entry sites (IRESs), specialized translation initiation requires the recruitment of eukaryotic initiation factor 3 (eIF3), but also requires cap recognition by eIF3d, a new 5'-m(7)GTP recognizing protein. How these RNA structures mediate eIF3 recruitment to affect translation of specific mRNAs remains unclear. Here, we report the nuclear magnetic resonance (NMR) structure of a stem-loop within the c-JUN 5' UTR recognized by eIF3 and essential for specialized translation initiation of this well-known oncogene. The structure exhibits similarity to eIF3 recognizing motifs found in hepatitis C virus (HCV)-like IRESs, suggesting mechanistic similarities. This work establishes the RNA structural features involved in c-JUN specialized translation initiation and provides a basis to search for small molecule inhibitors of aberrant expression of the proto-oncogenic c-JUN.
-
-	Structure of the RNA Specialized Translation Initiation Element that Recruits eIF3 to the 5'-UTR of c-Jun.,Walker MJ, Shortridge MD, Albin DD, Cominsky LY, Varani G J Mol Biol. 2020 Mar 27;432(7):1841-1855. doi: 10.1016/j.jmb.2020.01.001. Epub, 2020 Jan 14. PMID:31953146<ref>PMID:31953146</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 6mxq" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Shortridge, M]]	+	[[Category: Shortridge M]]
-	[[Category: Varani, G]]	+	[[Category: Varani G]]
-	[[Category: Walker, M]]	+	[[Category: Walker M]]
-	~~[[Category: C-jun]]~~	+
-	~~[[Category: Cap-dependent]]~~	+
-	~~[[Category: Eif3]]~~	+
-	~~[[Category: Mrna]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Specialized translation initiation~~]]	+

OCA at 09:47, 18 November 2020

OCA — Wed, 18 Nov 2020 09:47:10 GMT

←Older revision		Revision as of 09:47, 18 November 2020
Line 1:		Line 1:

	==Solution structure of a c-JUN 5' UTR stem-loop associated with specialized cap-dependent translation initiation==		==Solution structure of a c-JUN 5' UTR stem-loop associated with specialized cap-dependent translation initiation==
-	<StructureSection load='6mxq' size='340' side='right'caption='[[6mxq]]' scene=''>	+	<StructureSection load='6mxq' size='340' side='right'caption='[[6mxq]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MXQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mxq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MXQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MXQ FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxq OCA], [http://pdbe.org/6mxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mxq RCSB], [http://www.ebi.ac.uk/pdbsum/6mxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxq ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxq OCA], [http://pdbe.org/6mxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mxq RCSB], [http://www.ebi.ac.uk/pdbsum/6mxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxq ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Specialized translation initiation is a novel form of regulation of protein synthesis, whereby RNA structures within the 5'-UTR regulate translation rates of specific mRNAs. Similar to internal ribosome entry sites (IRESs), specialized translation initiation requires the recruitment of eukaryotic initiation factor 3 (eIF3), but also requires cap recognition by eIF3d, a new 5'-m(7)GTP recognizing protein. How these RNA structures mediate eIF3 recruitment to affect translation of specific mRNAs remains unclear. Here, we report the nuclear magnetic resonance (NMR) structure of a stem-loop within the c-JUN 5' UTR recognized by eIF3 and essential for specialized translation initiation of this well-known oncogene. The structure exhibits similarity to eIF3 recognizing motifs found in hepatitis C virus (HCV)-like IRESs, suggesting mechanistic similarities. This work establishes the RNA structural features involved in c-JUN specialized translation initiation and provides a basis to search for small molecule inhibitors of aberrant expression of the proto-oncogenic c-JUN.
		+
		+	Structure of the RNA Specialized Translation Initiation Element that Recruits eIF3 to the 5'-UTR of c-Jun.,Walker MJ, Shortridge MD, Albin DD, Cominsky LY, Varani G J Mol Biol. 2020 Mar 27;432(7):1841-1855. doi: 10.1016/j.jmb.2020.01.001. Epub, 2020 Jan 14. PMID:31953146<ref>PMID:31953146</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6mxq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Shortridge M]]	+	[[Category: Shortridge, M]]
-	[[Category: Varani G]]	+	[[Category: Varani, G]]
-	[[Category: Walker M]]	+	[[Category: Walker, M]]
		+	[[Category: C-jun]]
		+	[[Category: Cap-dependent]]
		+	[[Category: Eif3]]
		+	[[Category: Mrna]]
		+	[[Category: Rna]]
		+	[[Category: Specialized translation initiation]]

OCA at 05:59, 6 May 2020

OCA — Wed, 06 May 2020 05:59:57 GMT

←Older revision		Revision as of 05:59, 6 May 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6mxq is ON HOLD until Apr 30 2021~~	+	==Solution structure of a c-JUN 5' UTR stem-loop associated with specialized cap-dependent translation initiation==
-		+	<StructureSection load='6mxq' size='340' side='right'caption='[[6mxq]]' scene=''>
-	~~Authors: Walker, M., Shortridge, M., Varani, G.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MXQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6MXQ FirstGlance]. <br>
-	~~Description:~~ Solution structure of a c-JUN 5' UTR stem-loop associated with specialized cap-dependent translation initiation	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mxq OCA], [http://pdbe.org/6mxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mxq RCSB], [http://www.ebi.ac.uk/pdbsum/6mxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mxq ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Varani~~, G]]	+	__TOC__
-	[[Category: Shortridge, M]]	+	</StructureSection>
-	[[Category: Walker, M]]	+	[[Category: Large Structures]]
		+	[[Category: Shortridge M]]
		+	[[Category: Varani G]]
		+	[[Category: Walker M]]

OCA at 13:30, 11 December 2019

OCA — Wed, 11 Dec 2019 13:30:41 GMT

←Older revision		Revision as of 13:30, 11 December 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mxq is ON HOLD until ~~Jan 31~~ 2021	+	The entry 6mxq is ON HOLD until Apr 30 2021

	Authors: Walker, M., Shortridge, M., Varani, G.		Authors: Walker, M., Shortridge, M., Varani, G.

OCA at 04:21, 16 October 2019

OCA — Wed, 16 Oct 2019 04:21:03 GMT

←Older revision		Revision as of 04:21, 16 October 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mxq is ON HOLD until ~~Paper Publication~~	+	The entry 6mxq is ON HOLD until Jan 31 2021

	Authors: Walker, M., Shortridge, M., Varani, G.		Authors: Walker, M., Shortridge, M., Varani, G.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Varani, G]]		[[Category: Varani, G]]
-	[[Category: Walker, M]]
	[[Category: Shortridge, M]]		[[Category: Shortridge, M]]
		+	[[Category: Walker, M]]

OCA at 19:03, 2 December 2018

OCA — Sun, 02 Dec 2018 19:03:36 GMT

←Older revision		Revision as of 19:03, 2 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mxq is ON HOLD	+	The entry 6mxq is ON HOLD until Paper Publication

	Authors: Walker, M., Shortridge, M., Varani, G.		Authors: Walker, M., Shortridge, M., Varani, G.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Varani, G]]		[[Category: Varani, G]]
-	[[Category: Shortridge, M]]
	[[Category: Walker, M]]		[[Category: Walker, M]]
		+	[[Category: Shortridge, M]]

OCA: Protected "6mxq" [edit=sysop:move=sysop]

OCA — Wed, 07 Nov 2018 10:56:54 GMT

Protected "6mxq" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:56, 7 November 2018

OCA: New page: '''Unreleased structure''' The entry 6mxq is ON HOLD Authors: Walker, M., Shortridge, M., Varani, G. Description: Solution structure of a c-JUN 5' UTR stem-loop associated with special...

OCA — Wed, 07 Nov 2018 10:56:53 GMT

New page: '''Unreleased structure''' The entry 6mxq is ON HOLD Authors: Walker, M., Shortridge, M., Varani, G. Description: Solution structure of a c-JUN 5' UTR stem-loop associated with special...

New page

'''Unreleased structure'''

The entry 6mxq is ON HOLD

Authors: Walker, M., Shortridge, M., Varani, G.

Description: Solution structure of a c-JUN 5' UTR stem-loop associated with specialized cap-dependent translation initiation
[[Category: Unreleased Structures]]
[[Category: Varani, G]]
[[Category: Shortridge, M]]
[[Category: Walker, M]]