6mzp - Revision history

OCA at 10:26, 4 December 2019

OCA — Wed, 04 Dec 2019 10:26:51 GMT

←Older revision		Revision as of 10:26, 4 December 2019
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	<StructureSection load='6mzp' size='340' side='right'caption='[[6mzp]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6mzp' size='340' side='right'caption='[[6mzp]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mzp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MZP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mzp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MZP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mzp OCA], [http://pdbe.org/6mzp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mzp RCSB], [http://www.ebi.ac.uk/pdbsum/6mzp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mzp ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tgfbr3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mzp OCA], [http://pdbe.org/6mzp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mzp RCSB], [http://www.ebi.ac.uk/pdbsum/6mzp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mzp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brachidanio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hinck, A P]]		[[Category: Hinck, A P]]

OCA at 05:54, 21 August 2019

OCA — Wed, 21 Aug 2019 05:54:43 GMT

←Older revision		Revision as of 05:54, 21 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6mzp is ~~ON HOLD until Paper~~ Publication	+	==Zebrafish betaglycan orphan domain structure from orthorhombic crystal form==
		+	<StructureSection load='6mzp' size='340' side='right'caption='[[6mzp]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6mzp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MZP FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mzp OCA], [http://pdbe.org/6mzp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mzp RCSB], [http://www.ebi.ac.uk/pdbsum/6mzp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mzp ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Betaglycan (BG) and endoglin (ENG), homologous co-receptors of the TGF-beta family, potentiate the signaling activity of TGF-beta2 and inhibin A, and BMP-9 and BMP-10, respectively. BG exists as monomer and forms 1:1 growth factor (GF) complexes, while ENG exists as a dimer and forms 2:1 GF complexes. Herein, the structure of the BG orphan domain (BGO) reveals an insertion that blocks the region that the endoglin orphan domain (ENGO) uses to bind BMP-9, preventing it from binding in the same manner. Using binding studies with domain-deleted forms of TGF-beta and BGO, as well as small-angle X-ray scattering data, BGO is shown to bind its cognate GF in an entirely different manner compared with ENGO. The alternative interfaces likely engender BG and ENG with the ability to selectively bind and target their cognate GFs in a unique temporal-spatial manner, without interfering with one another or other TGF-beta family GFs.

-	~~Authors~~:	+	Structural Adaptation in Its Orphan Domain Engenders Betaglycan with an Alternate Mode of Growth Factor Binding Relative to Endoglin.,Kim SK, Whitley MJ, Krzysiak TC, Hinck CS, Taylor AB, Zwieb C, Byeon CH, Zhou X, Mendoza V, Lopez-Casillas F, Furey W, Hinck AP Structure. 2019 Jul 16. pii: S0969-2126(19)30231-X. doi:, 10.1016/j.str.2019.06.010. PMID:31327662<ref>PMID:31327662</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6mzp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hinck, A P]]
		+	[[Category: Kim, S]]
		+	[[Category: Co-receptor]]
		+	[[Category: Cytokine receptor]]
		+	[[Category: Protein binding]]
		+	[[Category: Proteoglycan]]

OCA at 19:05, 2 December 2018

OCA — Sun, 02 Dec 2018 19:05:11 GMT

←Older revision		Revision as of 19:05, 2 December 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mzp is ON HOLD	+	The entry 6mzp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6mzp" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2018 06:43:20 GMT

Protected "6mzp" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:43, 14 November 2018

OCA: New page: '''Unreleased structure''' The entry 6mzp is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 14 Nov 2018 06:43:18 GMT

New page: '''Unreleased structure''' The entry 6mzp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6mzp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]