6n01 - Revision history

OCA at 06:42, 11 October 2023

OCA — Wed, 11 Oct 2023 06:42:23 GMT

←Older revision		Revision as of 06:42, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6n01' size='340' side='right'caption='[[6n01]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='6n01' size='340' side='right'caption='[[6n01]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n01]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Citk8 Citk8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N01 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6N01 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n01]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Citrobacter_koseri_ATCC_BAA-895 Citrobacter koseri ATCC BAA-895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N01 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CKO_00948 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=290338 CITK8])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6n01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n01 OCA], [~~http~~://pdbe.org/6n01 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6n01 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6n01 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6n01 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n01 OCA], [https://pdbe.org/6n01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n01 RCSB], [https://www.ebi.ac.uk/pdbsum/6n01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n01 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A8AF35_CITK8 A8AF35_CITK8]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Citk8~~]]	+	[[Category: Citrobacter koseri ATCC BAA-895]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Neupane~~, D P~~]]	+	[[Category: Neupane DP]]
-	[[Category: Yukl~~, E T]]~~	+	[[Category: Yukl ET]]
-	~~[[Category: Beta propeller]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Metallochaperone]]~~	+
-	~~[[Category: Periplasm]]~~	+
-	~~[[Category: Zinc~~]]	+

OCA at 11:32, 1 January 2020

OCA — Wed, 01 Jan 2020 11:32:07 GMT

←Older revision		Revision as of 11:32, 1 January 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6n01 is ~~ON HOLD until Paper~~ Publication	+	==Structure of apo AztD from Citrobacter koseri==
		+	<StructureSection load='6n01' size='340' side='right'caption='[[6n01]], [[Resolution\|resolution]] 1.98Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6n01]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Citk8 Citk8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N01 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N01 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CKO_00948 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=290338 CITK8])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n01 OCA], [http://pdbe.org/6n01 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n01 RCSB], [http://www.ebi.ac.uk/pdbsum/6n01 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n01 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Zinc acquisition from limited environments is critical for bacterial survival and pathogenesis. AztD has been identified as a periplasmic or cell surface zinc-binding protein in numerous bacterial species. In Paracoccus denitrificans, AztD can transfer zinc directly to AztC, the solute binding protein for a zinc-specific ATP-binding cassette transporter system, suggesting a role in zinc acquisition and homeostasis. Here, we present the first cry stal structures of AztD from P. denitrificans and tbe human pathogen Citrobacter koseri, revealing a beta-propeller fold and two high-affinity zinc-binding sites that are highly conserved among AztD homologs. These structures combined with transfer assays using WT and mutant proteins provide rare insight into the mechanism of direct zinc transfer from one protein to another. Given the importance of zinc import to bacterial pathogenesis, these insights may prove valuable to the development of zinc transfer inhibitors as antibiotics.

-	~~Authors: Yukl, E.T~~., Neupane, D.P.	+	Crystal structures of AztD provide mechanistic insights into direct zinc transfer between proteins.,Neupane DP, Fullam SH, Chacon KN, Yukl ET Commun Biol. 2019 Aug 9;2:308. doi: 10.1038/s42003-019-0542-z. eCollection 2019. PMID:31428696<ref>PMID:31428696</ref>

-	~~Description: Structure~~ of ~~apo AztD from Citrobacter koseri~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
-	[[Category: Neupane, D.P]]	+	<div class="pdbe-citations 6n01" style="background-color:#fffaf0;"></div>
-	[[Category: Yukl, E.T]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Citk8]]
		+	[[Category: Large Structures]]
		+	[[Category: Neupane, D P]]
		+	[[Category: Yukl, E T]]
		+	[[Category: Beta propeller]]
		+	[[Category: Chaperone]]
		+	[[Category: Metallochaperone]]
		+	[[Category: Periplasm]]
		+	[[Category: Zinc]]

OCA at 19:05, 2 December 2018

OCA — Sun, 02 Dec 2018 19:05:32 GMT

←Older revision		Revision as of 19:05, 2 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n01 is ON HOLD	+	The entry 6n01 is ON HOLD until Paper Publication

	Authors: Yukl, E.T., Neupane, D.P.		Authors: Yukl, E.T., Neupane, D.P.

OCA: Protected "6n01" [edit=sysop:move=sysop]

OCA — Wed, 14 Nov 2018 06:44:22 GMT

Protected "6n01" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:44, 14 November 2018

OCA: New page: '''Unreleased structure''' The entry 6n01 is ON HOLD Authors: Yukl, E.T., Neupane, D.P. Description: Structure of apo AztD from Citrobacter koseri Category: Unreleased Structures [...

OCA — Wed, 14 Nov 2018 06:44:20 GMT

New page: '''Unreleased structure''' The entry 6n01 is ON HOLD Authors: Yukl, E.T., Neupane, D.P. Description: Structure of apo AztD from Citrobacter koseri Category: Unreleased Structures [...

New page

'''Unreleased structure'''

The entry 6n01 is ON HOLD

Authors: Yukl, E.T., Neupane, D.P.

Description: Structure of apo AztD from Citrobacter koseri
[[Category: Unreleased Structures]]
[[Category: Neupane, D.P]]
[[Category: Yukl, E.T]]